Abstract
Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.
Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade
Current Neurovascular Research
Title: Cerebrovascular Damage as a Cause for Alzheimers Disease
Volume: 2 Issue: 4
Author(s): C. Humpel and J. Marksteiner
Affiliation:
Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade
Abstract: Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.
Export Options
About this article
Cite this article as:
Humpel C. and Marksteiner J., Cerebrovascular Damage as a Cause for Alzheimers Disease, Current Neurovascular Research 2005; 2 (4) . https://dx.doi.org/10.2174/156720205774322610
DOI https://dx.doi.org/10.2174/156720205774322610 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
MicroRNA Expression Analysis of Adult-Onset Drosophila Alzheimer`s Disease Model
Current Alzheimer Research Genomics and Natural Products: Role of Bioinformatics and Recent Patents
Recent Patents on Biotechnology Glucocorticoids, the Etiology of Obesity and the Metabolic Syndrome
Current Alzheimer Research Galanin/GALP Receptors and CNS Homeostatic Processes
CNS & Neurological Disorders - Drug Targets Natural Proteinaceous Inhibitors of Serine Proteases
Current Pharmaceutical Design Computational Molecular Modeling of Compounds from Amaryllidaceae Family as Potential Acetylcholinesterase Inhibitors
Current Bioactive Compounds Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease
Current Alzheimer Research The Clinical Spectrum, Diagnosis, Pathogenesis and Treatment of Hashimotos Encephalopathy (Recurrent Acute Disseminated Encephalomyelitis)
Current Medicinal Chemistry Current Pharmacological Approach to Restore Endothelial Dysfunction
Cardiovascular & Hematological Agents in Medicinal Chemistry Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin
Current Medicinal Chemistry Clinical Assessment of Cognitive Decline in Adults with Down Syndrome
Current Alzheimer Research Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases
Current Medicinal Chemistry Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
Current Alzheimer Research Pharmacophore-based Drug Design of Novel Potential Tau Ligands for Alzheimer's Disease Treatment
Current Physical Chemistry Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer’s Disease
Current Alzheimer Research Glutamate Receptors in Microglia
CNS & Neurological Disorders - Drug Targets Implications of Parkinson’s Disease Pathophysiology for the Development of Cell Replacement Strategies and Drug Discovery in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Voxel-Based Morphometry of the Human Brain: Methods and Applications
Current Medical Imaging Striving for a Fuller Characterization of the Cellular Neuropathology of Depression Subtypes
Current Psychiatry Reviews Atypical Neurotransmitters and the Neurobiology of Depression
CNS & Neurological Disorders - Drug Targets