HTS Quality Control and Data Analysis: A Process to Maximize Information from a High-Throughput Screen

Title: HTS Quality Control and Data Analysis: A Process to Maximize Information from a High-Throughput Screen

Volume: 8 Issue: 6

Author(s): Ramesh Padmanabha, Lynda Cook and James Gill

Affiliation:

Keywords: Quality control, process control, primary screening, HTS

Abstract: Changes in all aspects of HTS from compound management through to evaluation of hits and leads, strengthened by infrastructure improvements, in both automation and informatics, have made possible increased analysis and implementation of process and quality control throughout HTS. This paper focuses on the process of HTS with an emphasis on quality control, reducing the variability of all the processes that have an impact on the final result, and argue that by increasing the quality of the entire process that data mining of primary screening data is in fact possible and will reduce cycle times to medicinal chemistry.

Cite this article as:

Ramesh Padmanabha , Lynda Cook and James Gill , HTS Quality Control and Data Analysis: A Process to Maximize Information from a High-Throughput Screen, Combinatorial Chemistry & High Throughput Screening 2005; 8 (6) . https://dx.doi.org/10.2174/1386207054867274