Abstract
The principal initiator of coagulation, Tissue Factor (TF) has now emerged as a critical key player in oncogenic events. TF regulates tumor growth through processes such as anti-apoptosis, tumor angiogenesis and metastasis in various solid tumors such as colorectal carcinoma, glioma and breast tumors. In the last few years it has become clear that these effects are not, or partially, attributable to activation of coagulation. Rather, activation of cellular receptors, by the binary TF:FVIIa complex, the ternary TF:FVIIa:FXa complex or by thrombin, results in intracellular signaling and altered cell behaviour. In this review, the role of TF in complex with FVIIa or FVIIa:FXa as well as the role of the Tissue Factor Pathway Inhibitor in cancer will be discussed.
Keywords: MALIGNANT TUMORS, breast cancer cells, TFPI-2 expression, ANGIOGENESIS, PAR isoforms, MAP kinase
Current Genomics
Title: Emerging Insights in the Role of Tissue Factor in Cancer
Volume: 6 Issue: 6
Author(s): H. H. Versteeg
Affiliation:
Keywords: MALIGNANT TUMORS, breast cancer cells, TFPI-2 expression, ANGIOGENESIS, PAR isoforms, MAP kinase
Abstract: The principal initiator of coagulation, Tissue Factor (TF) has now emerged as a critical key player in oncogenic events. TF regulates tumor growth through processes such as anti-apoptosis, tumor angiogenesis and metastasis in various solid tumors such as colorectal carcinoma, glioma and breast tumors. In the last few years it has become clear that these effects are not, or partially, attributable to activation of coagulation. Rather, activation of cellular receptors, by the binary TF:FVIIa complex, the ternary TF:FVIIa:FXa complex or by thrombin, results in intracellular signaling and altered cell behaviour. In this review, the role of TF in complex with FVIIa or FVIIa:FXa as well as the role of the Tissue Factor Pathway Inhibitor in cancer will be discussed.
Export Options
About this article
Cite this article as:
Versteeg H. H., Emerging Insights in the Role of Tissue Factor in Cancer, Current Genomics 2005; 6 (6) . https://dx.doi.org/10.2174/138920205774482936
DOI https://dx.doi.org/10.2174/138920205774482936 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Melanocortin Receptor Type 3 as a Potential Target for Anti-Inflammatory Therapy
Current Drug Targets - Inflammation & Allergy Decreasing the Metastatic Potential in Cancers - Targeting the Heparan Sulfate Proteoglycans
Current Drug Targets Patent Selections
Recent Patents on Biomarkers In Vitro Regulatory Effect of Epididymal Serpin CRES on Protease Activity of Proprotein Convertase PC4/PCSK4
Current Molecular Medicine Recent Progress in Cerebrovascular Gene Therapy
Current Neurovascular Research Cancer Stem-Cells Patents in the Context of their Therapeutic Purposes: Exploring the Latest Trends (2011-2015)
Recent Patents on Regenerative Medicine Theranostic Radiopharmaceuticals Targeting Cancer-Associated Fibroblasts
Current Radiopharmaceuticals Physiological and Pathological Functions of Acid-Sensing Ion Channels in the Central Nervous System
Current Drug Targets The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory
Current Pharmaceutical Design Benzamides as Melanotropic Carriers for Radioisotopes, Metals, Cytotoxic Agents and as Enzyme Inhibitors
Current Medicinal Chemistry The Role of Cetuximab and Other Epidermal Growth Factor Receptor Monoclonal Antibodies in the Treatment of Advanced Non-Small Cell Lung Cancer
Reviews on Recent Clinical Trials Extracellular ATP and Neurodegeneration
Current Drug Targets - CNS & Neurological Disorders An Insight into Drug Repositioning for the Development of Novel Anti-Cancer Drugs
Current Topics in Medicinal Chemistry Vascular Targeting: A New Antitumor Activity
Drug Design Reviews - Online (Discontinued) Ceramidases in Hematological Malignancies: Senseless or Neglected Target?
Anti-Cancer Agents in Medicinal Chemistry Synthesis and Broad Spectrum Antibacterial Activity of Magnetite Ferrofluid
Current Nanoscience Induced pluripotent stem cell-derived mesenchymal stem cells: A leap toward personalized therapies.
Current Stem Cell Research & Therapy Recent Trends of Chalcones Potentialities as Antiproliferative and Antiresistance Agents
Anti-Cancer Agents in Medicinal Chemistry Relationship with Programmed Cell Death Ligand 1 (PD-L1) and DTI Features in Brain Metastases of Non-small Cell Lung Cancer: A Preliminary Study
Current Medical Imaging Protein Geranylgeranyltransferase Type 1 as a Target in Cancer
Current Cancer Drug Targets