Abstract
Combinatorial chemistry has been well recognized as an important tool of drug discovery. An ongoing hand is to integrate the combinatorial approach with fundamentals of medicinal chemistry and rational drug design. The last five years has seen an explosion in the exploration and adoption of combinatorial techniques. Indeed, it is difficult to identify any other topic in chemistry that has ever caught the imagination of chemists with such fervor and with the continuous development of high throughput screening methods. There is a growing need for the synthesis of a large number of molecules. Compound libraries designed to produce specific inhibitors of therapeutic target proteins have generated significant interest in drug discovery research. Combinatorial chemistry provides the opportunity to generate large libraries of compounds for biological testing. A literature search revealed that many lead compounds have indeed been discovered from libraries and this review presents a survey of combinatorial synthesis of HIV-1 reverse transcriptase inhibitors, protease inhibitors, HIV-1 function inhibitors such as adsorption inhibitors, CCR5 antagonists and HIV-1 Tat-tar inhibitors that can be developed as potential anti-HIV drugs.
Keywords: anti-hiv, reverse transcriptase inhibitors, protease inhibitors, adsorption inhibitors, tat-tar inhibitors, ccr antagonist
Combinatorial Chemistry & High Throughput Screening
Title: Combinatorial Synthesis of Anti-HIV Agents-A Review
Volume: 8 Issue: 5
Author(s): Dharmarajan Sriram, Perumal Yogeeswari and Ananantha Naik Nagappa
Affiliation:
Keywords: anti-hiv, reverse transcriptase inhibitors, protease inhibitors, adsorption inhibitors, tat-tar inhibitors, ccr antagonist
Abstract: Combinatorial chemistry has been well recognized as an important tool of drug discovery. An ongoing hand is to integrate the combinatorial approach with fundamentals of medicinal chemistry and rational drug design. The last five years has seen an explosion in the exploration and adoption of combinatorial techniques. Indeed, it is difficult to identify any other topic in chemistry that has ever caught the imagination of chemists with such fervor and with the continuous development of high throughput screening methods. There is a growing need for the synthesis of a large number of molecules. Compound libraries designed to produce specific inhibitors of therapeutic target proteins have generated significant interest in drug discovery research. Combinatorial chemistry provides the opportunity to generate large libraries of compounds for biological testing. A literature search revealed that many lead compounds have indeed been discovered from libraries and this review presents a survey of combinatorial synthesis of HIV-1 reverse transcriptase inhibitors, protease inhibitors, HIV-1 function inhibitors such as adsorption inhibitors, CCR5 antagonists and HIV-1 Tat-tar inhibitors that can be developed as potential anti-HIV drugs.
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Cite this article as:
Sriram Dharmarajan, Yogeeswari Perumal and Nagappa Naik Ananantha, Combinatorial Synthesis of Anti-HIV Agents-A Review, Combinatorial Chemistry & High Throughput Screening 2005; 8 (5) . https://dx.doi.org/10.2174/1386207054546540
DOI https://dx.doi.org/10.2174/1386207054546540 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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