Current Molecular Medicine

Mass Spectrometric Analysis of L-carnitine and its Esters: Potential Biomarkers of Disturbances in Carnitine Homeostasis open access plus

Volume: 20   Issue: 5
Pp: 336-354
Judit Bene*, Andras Szabo, Katalin Komlósi and Bela Melegh
DOI: 10.2174/1566524019666191113120828

Dynorphins in Development and Disease: Implications for Cardiovascular Disease

Volume: 20   Issue: 4
Pp: 259-274
Cody Cissom, Jason J. Paris and Zia Shariat-Madar*
DOI: 10.2174/1566524019666191028122559

High Throughput Multiplex SNP-analysis in Chronic Obstructive Pulmonary Disease and Lung Cancer

Volume: 20   Issue: 3
Pp: 185-193
Zsuzsanna Elek, Zsuzsanna Kovács, Gergely Keszler, Miklós Szabó, Eszter Csanky, Jane Luo, András Guttman and Zsolt Rónai*
DOI: 10.2174/1566524019666191017123446

The Effects of Cholesterol Metabolism on Follicular Development and Ovarian Function

Volume: 19   Issue: 10
Pp: 719-730
Qin Huang, Yannan Liu, Zhen Yang, Yuanjie Xie and Zhongcheng Mo*
DOI: 10.2174/1566524019666190916155004

The Molecular Pathology of Eye Tumors: A 2019 Update Main Interests for Routine Clinical Practice

Volume: 19   Issue: 9
Pp: 632-664
Sacha Nahon-Esteve, Arnaud Martel, Célia Maschi, Jean-Pierre Caujolle, Stéphanie Baillif, Sandra Lassalle* and Paul Hofman*
DOI: 10.2174/1566524019666190726161044

Novel Insight into Differential Gene Expression and Clinical Significance of Dopamine Receptors, COMT, and IL6 in BPH and Prostate Cancer

Volume: 19   Issue: 8
Pp: 605-619
Fatemeh Akbarian, Maryam Abolhasani, Farid Dadkhah, Farrokh Asadi and Ghasem Ahangari*
DOI: 10.2174/1566524019666190709180146

Investigation of the Adsorption Rubraca Anticancer Drug on the CNT(4,4-8) Nanotube as a Factor of Drug Delivery: A Theoretical Study Based on DFT Method

Volume: 19   Issue: 7
Pp: 473-486
Masoome Sheikhi*, Siyamak Shahab, Mehrnoosh Khaleghian, Mahin Ahmadianarog, Fatemeh Azarakhshi and Rakesh Kumar
DOI: 10.2174/1566524019666190506143152

Inhibition of Sumoylation Alleviates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Represses Proinflammatory Gene Expression

Volume: 18   Issue: 9
Pp: 575-583
Q. Sun, W. Qing, R. Qi, M. Zou, L. Gong*, Y. Liu* and D.W.-C. Li*
DOI: 10.2174/1566524019666190107154250

Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis

Volume: 18   Issue: 8
Pp: 542-549
Qian Nie, Ling Wang , Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen and David Wan-Cheng Li*
DOI: 10.2174/1566524019666190111152324

Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats

Volume: 18   Issue: 7
Pp: 436-447
Rui Zheng, Xiaoliang Fang, Lei He, Yanjiao Shao, Nana Guo, Liren Wang, Mingyao Liu, Dali Li* and Hongquan Geng*
DOI: 10.2174/1566524019666181212092440

Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1

Volume: 18   Issue: 6
Pp: 392-399
Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, Guolin Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou*, Jin Liu* and Youjun Wang
DOI: 10.2174/1566524018666181113111316

Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells

Volume: 18   Issue: 4
Pp: 199-206
J. Castillo Bennett, P. Silva, S. Martinez, V.A. Torres* and A.F.G. Quest*
DOI: 10.2174/1566524018666180926163218

An Antioxidant Role by Minocycline Via Enhancing the Activation of LKB1/AMPK Signaling in the Process of Cerebral Ischemia Injury

Volume: 18   Issue: 3
Pp: 142-151
Z. Cai*, C. Wang, Y. Chen and W. He
DOI: 10.2174/1566524018666180907161504

HMGA2 Modulates the TGFβ/Smad, TGFβ/ERK and Notch Signaling Pathways in Human Lens Epithelial-Mesenchymal Transition

Volume: 18   Issue: 2
Pp: 71-82
M. Hou, X. Bao, F. Luo, X. Chen, L. Liu and M. Wu*
DOI: 10.2174/1566524018666180705104844

Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer open access plus

Volume: 18   Issue: 2
Pp: 100-108
Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*
DOI: 10.2174/1566524018666180705111342

LOH12CR1 is a Novel Tumor Suppressor Inhibiting Tumor Growth Through Deregulation of G1/S Checkpoint in Human Colorectal Carcinoma

Volume: 18   Issue: 1
Pp: 25-35
H. Huang, H. Shen, Y. Wang, X. Wang, Q. Chen, Y. Wang, H. Yan, Z. Liu and X. Shi*
DOI: 10.2174/1566524018666180608084005

Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

Volume: 17   Issue: 10
Pp: 668-688
N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*
DOI: 10.2174/1566524018666180416100142

Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development open access plus

Volume: 17   Issue: 9
Pp: 627-636
F. Chen, W. Yuan, X. Mo, J. Zhuang, Y. Wang, J. Chen, Z. Jiang, X. Zhu, Q. Zeng, Y. Wan, F. Li, Y. Shi, L. Cao, X. Fan, S. Luo, X. Ye, Y. Chen, G. Dai, J. Gao, X. Wang, H. Xie*, P. Zhu*, Y. Li* and X. Wu*
DOI: 10.2174/1566524018666180308113909

Immunotherapy in Non-Small Cell Lung Cancer: Biological Principles and Future Opportunities

Volume: 17   Issue: 8
Pp: 527-540
M. Ilie, J. Benzaquen, V. Hofman, S. Lassalle, N. Yazbeck, S. Leroy, S. Heeke, C. Bence, B. Mograbi, N. Glaichenhaus, C.-H. Marquette and P. Hofman*
DOI: 10.2174/1566524018666180222114038

Neuronal Expression of Junctional Adhesion Molecule-C is Essential for Retinal Thickness and Photoreceptor Survival

Volume: 17   Issue: 7
Pp: 497-508
Y. Li, F. Zhang, W. Lu* and X. Li*
DOI: 10.2174/1566524018666180212144500

Human Umbilical Cord Mesenchymal Stem Cells: Subpopulations and Their Difference in Cell Biology and Effects on Retinal Degeneration in RCS Rats

Volume: 17   Issue: 6
Pp: 421-435
L. Wang, P. Li, Y. Tian, Z. Li, C. Lian, Q. Ou, C. Jin, F. Gao, J.-Y. Xu, J. Wang, F. Wang, J. Zhang, J. Zhang, W. Li, H. Tian*, L. Lu* and G.-T. Xu*
DOI: 10.2174/1566524018666171205140806

Inhibition of JAK2 Signaling Alleviates Hyperlipidemia-Intensified Caerulin-Induced Acute Pancreatitis In Vivo

Volume: 17   Issue: 5
Pp: 381-387
F. Zhu*, Y. Guan and R. Zhang
DOI: 10.2174/1566524018666171205123723

The Fate of In Situ Lens Regeneration is Determined by Capsulorhexis Size

Volume: 17   Issue: 4
Pp: 270-279
X. Tan, Z. Liu, Y. Zhu, C. Chen, S. Huang, B. Chen, Z. Lin, J. Chen, X. Tang, B. Qu, X. Liu, L. Luo, J. Deng, F. Shang, M. Wu, W. Chen, H. Lin* and Y. Liu*
DOI: 10.2174/1566524017666171106110304

A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis open access plus

Volume: 17   Issue: 3
Pp: 211-220
S. De Majumdar, M. Subinya, J. Korward, A. Pettigrew, D. Scherer and H. Xu*
DOI: 10.2174/1566524017666170807144009

Expression of Dominant Negative K6W-Ubiquitin in the Lens Epithelium via an Adenoviral Vector Delays Posterior Capsule Opacification in a Rabbit Model

Volume: 17   Issue: 2
Pp: 160-168
X. Bao, M. Hou, R. Peng, F. Luo and M. Wu*
DOI: 10.2174/1566524017666170331163751

Molecular Determinants for STIM1 Activation During Store- Operated Ca2+ Entry

Volume: 17   Issue: 1
Pp: 60-69
G. Ma, S. Zheng, Y. Ke, L. Zhou, L. He, Y. Huang, Y. Wang* and Y. Zhou*
DOI: 10.2174/1566524017666170220103731

Sumoylation in Lens Differentiation and Pathogenesis

Volume: 16   Issue: 10
Pp: 859-870
J.-W. Xiang, Z.-G. Chen, L. Gong, Y. Xiao, W.-J. Qing, L. Wang, X.-H. Hu, Z.-X. Huang, R.-L. Qi, T.-H. Yang, A.-P. Arrigo, L. Zhang, X.-C. Tang, S. Huang, F.-Y. Liu, Z.-W. Luo, Y.-F. Liu, Q. Sun, J. Gigantelli, Y.-Z. Liu and D. W.-C. Li
DOI: 10.2174/1566524017666170109123238

Spinal Muscular Atrophy: More than a Disease of Motor Neurons?

Volume: 16   Issue: 9
Pp: 779-792
L. A. Nash, J. K. Burns, J. Warman Chardon, R. Kothary and R. J. Parks
DOI: 10.2174/1566524016666161128113338

High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells

Volume: 16   Issue: 7
Pp: 668-676
F. Zhu, Y. Guan and R. Zhang
DOI: 10.2174/1566524016666160721143947

Cardiomyocyte-Specific TβR2 Knockout Mice are More Susceptible to Cardiac Hypertrophy Induced by Adrenergic Agonist Stimulation

Volume: 16   Issue: 5
Pp: 496-503
X. Fan, L. Liu, Z. Li, X. Peng, Z. Jiang, Y. Guan, X. Wu, X. Yang and J. Wang
DOI: 10.2174/1566524016666160429121143

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration open access plus

Volume: 16   Issue: 4
Pp: 412-423
M. Chen, J. Lechner, J. Zhao, L. Toth, R. Hogg, G. Silvestri, A. Kissenpfennig, U. Chakravarthy and H. Xu
DOI: 10.2174/1566524016666160324130031

Nitric Oxide and Major Depressive Disorder: Pathophysiology and Treatment Implications promotion: free to download

Volume: 16   Issue: 2
Pp: 206-215
P. Kudlow, D.S. Cha, A.F. Carvalho and R.S. McIntyre
DOI: 10.2174/1566524016666160126144722

Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.

Volume: 16   Issue: 1
Pp: 83-90
G. Zhou, J. Yu, A. Wang, S.-H. Liu, J. Sinnett-Smith, J. Wu, R. Sanchez, J. Nemunaitis, C. Ricordi, E. Rozengurt and F.C. Brunicardi
DOI: 10.2174/1566524016666151222145551

Endothelial Progenitor Cells in Sprouting Angiogenesis: Proteases Pave the Way

Volume: 15   Issue: 7
Pp: 606-620
A. Laurenzana, G. Fibbi, F. Margheri, A. Biagioni, C. Luciani, M. Del Rosso and A. Chilla
DOI: 10.2174/1566524015666150831131214

Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis

Volume: 15   Issue: 6
Pp: 511-516
R. Horai, W.P. Chong, R. Zhou, J. Chen, P.B. Silver, R.K. Agarwal and R.R. Caspi
DOI: 10.2174/1566524015666150731095201

Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801 open access plus

Volume: 15   Issue: 3
Pp: 222-236
T. Kato, Y. Abe, S. Hirokawa, Y. Iwakura, M. Mizuno, H. Namba and H. Nawa
DOI: 10.2174/1566524015666150330143300

Wip1-Deficient Neutrophils Significantly Promote Intestinal Ischemia/Reperfusion Injury in Mice promotion: free to download

Volume: 15   Issue: 1
Pp: 100-108
J. Du, X. Shen, Y. Zhao, X. Hu, B. Sun, W. Guan, S. Li and Y. Zhao
DOI: 10.2174/1566524015666150114122929

Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse

Volume: 14   Issue: 10
Pp: 1286-1298
T. Ning, J. Li, K. Lin, H. Xiao, S. Wylie, S. Hua, H. Li and Y.-P. Zhang
DOI: 10.2174/1566524014666141203100940

Analysis of Mitochondrial Respiratory-Related Genes Reveals Nuclear and Mitochondrial Genome Cooperation in Allotetraploid Hybrid

Volume: 14   Issue: 10
Pp: 1314-1321
L.-Y. Peng, J. Wang, M. Tao, C.-P. You, L. Ye, J. Xiao, C. Zhang, Y. Liu and S.-J. Liu
DOI: 10.2174/1566524014666141203095503

Histone Cleavage as a Mechanism for Epigenetic Regulation: Current Insights and Perspectives

Volume: 14   Issue: 9
Pp: 1164-1172
P. Zhou, E. Wu, H.B. Alam and Y. Li
DOI: 10.2174/1566524014666141015155630

The Effect of Claudin-5 Overexpression on the Interactions of Claudin-1 and -2 and Barrier Function in Retinal Cells

Volume: 14   Issue: 9
Pp: 1226-1237
R. Tian, Y. Luo, Q. Liu, M. Cai, J. Li, W. Sun, J. Wang, C. He, Y. Liu and X. Liu
DOI: 10.2174/1566524014666141015160355

Parkinson Disease Genetics: A "Continuum" from Mendelian to Multifactorial Inheritance

Volume: 14   Issue: 8
Pp: 1079-1088
S. Petrucci, F. Consoli and E.M. Valente
DOI: 10.2174/1566524014666141010155509