ISSN (Print): 1871-5257
ISSN (Online): 1875-6182
Volume 18, 2 Issues, 2020
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ISSN (Print): 1871-5257
ISSN (Online): 1875-6182
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Frontiers in Clinical Drug Research-Hematology
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The proposed thematic issue is intended to discuss the pharmacological and medicobiological applications of potential
active chemicals derived from natural products. The proposed thematic issue of “Natural Products Chemistry
and Drug Design - 2020” to Bentham science under the journal of Cardiovascular and Hematological Agents in
Medicinal chemistry is comprised of 16 research and review articles. The side effects associated with conventional
treatment regimen prompted the researchers to explore alternative strategies, among which natural products assume
a greater role. The key findings to be published under this theme will be more prompt and the chemical entities of
the natural products identified will be helpful for the treatment of diseases and also enable future researches to design
the drugs. Substantially, the publications under this thematic issue would identify natural products which will
be useful in the treatment of debilitating diseases like cardiovascular diseases, diabetes, arthritis, cancer, liver diseases,
etc., Advancements in the technology involved in the production of natural products and their efficacies in
drug designing would be given priority thus identifying and highlighting their pharmaceutical applications. From
the above information, the proposal concludes that this thematic issue will be a milestone for the future endeavors
and prospective research.
The issue is comprised of 16 articles in three parts and each part of the issue comprises 5 articles presenting current
research and review models for various interactions related to plant materials, ayurvedic and allopathic drugs.
The following is a brief description of selected articles:
The opening of the first article is a review article Kalaiseziyen et al., that deals with the updated information of
scientific research and reports available in different aspects of the plant involving pharmacological activities and
therapeutical applications against various syndromes . In a research article, the authors Rathinasamy et al., deal
with the Biochanin-A that may alleviate the derangement of HFD-induced trace element metabolism by modulating
hyperglycemic and insulin resistance status and altering hepcidin and HO-1 . In another research article, the authors
Govindasami et al., deal with the therapeutic potential of Biochanin-A with significantly increased levels of
antioxidant enzymes, confirming that pretreatment provides useful information for developing a new safe drug
against cardiotoxicity in rats . The research article by authors Kalidhindi et al., discuss Asiatic acid, derived from
Centella Asiatica in the renal retrieve and derangements of Streptozotocin - Nicotinamide treated Diabetic rats and
analyzed the protection against renal dysfunction by attenuating carbohydrate metabolic disorder . The research
article by Anand et al., focus on the fabrication and characterization of Lomustine-doped polymer chitosan nanoparticles
to treat brain targeting diseases through experiments of Box-Behnken design and analytical schemes .
We are grateful to all the authors and reviewers for contributing to this current thematic special issue: “Natural
Products Chemistry and Drug Design - 2020”. Moreover, we, the guest editors, (Dr. Rajesh Pandiyan, Dr. Saravanan
Ganapathy, Dr. M. Sridhar Muthusami and Dr. Hariprasath Lakshmanan) would like to pay gratitude to the
journal “Cardiovascular and Hematological Agents in Medicinal Chemistry” for providing us the great opportunity
to complete this thematic issue.
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