Abstract
Diabetes is a complex nature. To alleviate this, nutritional intervention provides much scope and hope, and taurine has been placed under this category successfully. An adult human weighing 70 kg contains about 70 g taurine. Taurine in diabetes has an age old story; taurine is involved in the development and protection of insulin apparatus. Taurine and insulin both have mutual stimulating actions with hypoglycemic properties. On the clinical front, taurine supplementation has acceptable beneficial effect in platelet aggregation and to name a few more, in neuropathy, cardiomyopathy, nephropathy and retinopathy. Recent studies have provided a role for taurine in fetal development and also in blocking the transfer of diabetes from diabetic mother to offspring. A number of mechanisms for taurines actions have been advocated, from osmoregulation to anti-oxidation. Though sulfonylurea and recently introduced thiazolidinediones are effective, they are also not free from complications, thus needs to design new therapeutics. As taurine is also a sulfonyl derivative and it will be of great interest to develop taurine analogues as an alternative therapy. Considering the great involvement of taurine in diabetes, this review may provide a holistic view of taurine in diabetes and in its prevention, in this century.
Keywords: Taurine and diabetes
Current Diabetes Reviews
Title: Taurine-Diabetes Interaction: From Involvement to Protection
Volume: 3 Issue: 3
Author(s): Sung-Jin Kim, Ramesh C. Gupta and Hyeon Woo Lee
Affiliation:
Keywords: Taurine and diabetes
Abstract: Diabetes is a complex nature. To alleviate this, nutritional intervention provides much scope and hope, and taurine has been placed under this category successfully. An adult human weighing 70 kg contains about 70 g taurine. Taurine in diabetes has an age old story; taurine is involved in the development and protection of insulin apparatus. Taurine and insulin both have mutual stimulating actions with hypoglycemic properties. On the clinical front, taurine supplementation has acceptable beneficial effect in platelet aggregation and to name a few more, in neuropathy, cardiomyopathy, nephropathy and retinopathy. Recent studies have provided a role for taurine in fetal development and also in blocking the transfer of diabetes from diabetic mother to offspring. A number of mechanisms for taurines actions have been advocated, from osmoregulation to anti-oxidation. Though sulfonylurea and recently introduced thiazolidinediones are effective, they are also not free from complications, thus needs to design new therapeutics. As taurine is also a sulfonyl derivative and it will be of great interest to develop taurine analogues as an alternative therapy. Considering the great involvement of taurine in diabetes, this review may provide a holistic view of taurine in diabetes and in its prevention, in this century.
Export Options
About this article
Cite this article as:
Sung-Jin Kim , Ramesh C. Gupta and Hyeon Woo Lee , Taurine-Diabetes Interaction: From Involvement to Protection, Current Diabetes Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339907781368940
DOI https://dx.doi.org/10.2174/157339907781368940 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Risk Profiles in Type 2 Diabetes (Metabolic Syndrome): Integration of IL-10 Polymorphisms and Laboratory Parameters to Identify Vascular Damages Related Complications
Current Pharmaceutical Design Critical Overview of Applications of Genetic Testing in Sport Talent Identification
Recent Patents on DNA & Gene Sequences New Approach to Immunotherapy Against Organ-specific Autoimmune Diseases with T Cell Receptor and Chemokine Receptor DNA Vaccines
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Characterizing the Bi-Subunit Type IB DNA Topoisomerase of Leishmania Parasites; a Novel Scenario for Drug Intervention in Trypanosomatids
Current Drug Targets Piperine: Medicinal, Analytical and Therapeutics perspective
Current Bioactive Compounds Dynamics of T Cells Repertoire During Trypanosoma cruzi Infection and its Post-Treatment Modulation
Current Medicinal Chemistry Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach
Current Gene Therapy Cellular Strategies to Combat Protein Misfolding: Intricate Role of Hsp70 in Stress Management
Current Chemical Biology The Two fACEs of the Tissue Renin-Angiotensin Systems: Implication in Cardiovascular Diseases
Current Pharmaceutical Design Pharmacogenetically Tailored Treatments for Heart Disease
Current Pharmaceutical Design Use of Bromine-76 and Iodine-123 Radiohalogenated Tracers in the Drug Development Process
Current Pharmaceutical Design Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Ryanodine Receptor as Insecticide Target
Current Pharmaceutical Design Endothelin Receptor Antagonists: Another Potential Alternative for Cardiovascular Diseases
Current Drug Targets - Cardiovascular & Hematological Disorders Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part B))
Current Pharmaceutical Design Voltammetric Stripping Methods for Direct Determination of Disopyramide
Current Pharmaceutical Analysis TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook
Current Drug Targets Pharmacogenomics of Cardiovascular Complications in Diabetes and Obesity
Recent Patents on Biotechnology The CD4C/HIVNef Transgenic Model of AIDS
Current HIV Research Characterization of Supraventricular Tachycardia in Infants: Clinical and Instrumental Diagnosis
Current Pharmaceutical Design