Abstract
Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components.
Keywords: Molecular targets, cancer prevention, nutrigenomics, bioactive food components
Current Cancer Drug Targets
Title: Molecular Targets for Nutritional Preemption of Cancer
Volume: 7 Issue: 5
Author(s): Cindy D. Davis and John A. Milner
Affiliation:
Keywords: Molecular targets, cancer prevention, nutrigenomics, bioactive food components
Abstract: Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components.
Export Options
About this article
Cite this article as:
Cindy D. Davis and John A. Milner , Molecular Targets for Nutritional Preemption of Cancer, Current Cancer Drug Targets 2007; 7 (5) . https://dx.doi.org/10.2174/156800907781386560
DOI https://dx.doi.org/10.2174/156800907781386560 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oxidative Stress and its Clinical Consequences: Relationship between Diabetes and Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Renin-Angiotensin-Aldosterone System: A Current Drug Target for the Management of Neuropathic Pain
Current Drug Targets Neuro-endocrine Markers in Neoplasms. Diagnostic Interest and Future Prospects
Current Proteomics Ubiquitin-Protein Ligases - Novel Therapeutic Targets?
Current Protein & Peptide Science Transferrin and the Transferrin Receptor: Of Magic Bullets and Other Concerns
Inflammation & Allergy - Drug Targets (Discontinued) Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources
Current Drug Targets Thyroid Function and Obesity: From Mechanisms to the Benefits of Levothyroxine in Obese Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Src Tyrosine Kinase Inhibition Suppresses Lymphangiogenesis In Vitro and In Vivo
Current Cancer Drug Targets Bench to Bedside Targeting of FLT3 in Acute Leukemia
Current Drug Targets HDAC Inhibitors as Novel Anti-Cancer Therapeutics
Recent Patents on Anti-Cancer Drug Discovery TRPM8 Biology and Medicinal Chemistry
Current Topics in Medicinal Chemistry In Silico Identification of Human miR 3654 and its Targets Revealed its Involvement in Prostate Cancer Progression
MicroRNA Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases
Current Protein & Peptide Science Phytosterols in Physiological Concentrations Target Multidrug Resistant Cancer Cells
Medicinal Chemistry Epigenetic Modifications in Acute Lymphoblastic Leukemia: From Cellular Mechanisms to Therapeutics
Current Gene Therapy Protein Targeting Constructs in Alpha Therapy
Current Radiopharmaceuticals Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors
Current Medicinal Chemistry Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer
Current Medicinal Chemistry Editorial: [Hot Topic: Non-Analgesic Effects of Opioids]
Current Pharmaceutical Design Targeting Cyclooxygenase-2 in Hematological Malignancies: Rationale and Promise
Current Pharmaceutical Design