Abstract
Leukoaraiosis (LA or white matter changes of the brain) is a common finding on brain imaging studies in the elderly people. LA predisposes to dementia, ischemic stroke, intracerebral hemorrhage, and cognitive decline as well as associates with a significant increase in falls and gait disorders. As population ages, the incidence of LA increases and is becoming a major global health problem. Therefore, strategies for its prevention and management are urgently needed. This review includes basic knowledge on the pathophysiology, patterns of clinical presentation, risk factors, and imaging findings of LA. The very last and the most comprehensive part of this review discusses potential therapeutic approaches of the future.
Keywords: White matter, leukoaraiosis, MRI, diffusion, perfusion, ischemia, brain, therapy
Current Drug Targets
Title: Treatment of Leukoaraiosis: A Futuristic View
Volume: 8 Issue: 7
Author(s): Johanna Helenius and Turgut Tatlisumak
Affiliation:
Keywords: White matter, leukoaraiosis, MRI, diffusion, perfusion, ischemia, brain, therapy
Abstract: Leukoaraiosis (LA or white matter changes of the brain) is a common finding on brain imaging studies in the elderly people. LA predisposes to dementia, ischemic stroke, intracerebral hemorrhage, and cognitive decline as well as associates with a significant increase in falls and gait disorders. As population ages, the incidence of LA increases and is becoming a major global health problem. Therefore, strategies for its prevention and management are urgently needed. This review includes basic knowledge on the pathophysiology, patterns of clinical presentation, risk factors, and imaging findings of LA. The very last and the most comprehensive part of this review discusses potential therapeutic approaches of the future.
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Cite this article as:
Johanna Helenius and Turgut Tatlisumak , Treatment of Leukoaraiosis: A Futuristic View, Current Drug Targets 2007; 8 (7) . https://dx.doi.org/10.2174/138945007781077436
DOI https://dx.doi.org/10.2174/138945007781077436 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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