Abstract
The synthesis of unnatural α-amino acids is an area of research that has gained a lot of attention in recent years. The availability of synthetic methods for novel unnatural αamino acid derivatives and related compounds will be a critical point in the de novo design of molecules that mimic the conformation of the natural, active peptides. These molecules (peptidomimetics) are designed to display high receptor affinity and selectivity, in addition to enhanced bioavailability and metabolic stability. This review focuses on selected recent synthetic methodologies leading to unnatural α-amino acids including chiral catalysts that enable enantioselective synthesis and microwave-assisted synthesis. Solid phase synthesis and construction of organometallic αamino acids reveal the scope of influence that this field has in organic chemistry. Additionally, the article is aimed to provide a brief insight into the biosynthetic approaches to the synthesis of α-amino acid derivatives, and to give the reader an appreciation of the field.
Keywords: Arylglycine derivatives, Dehydroamino Acid Derivatives, N-Methylation, USP methodology, Hydrogenation, Proline Derivatives
Current Organic Chemistry
Title: Recent Advances in the Synthesis of Unnatural α-Amino Acids
Volume: 11 Issue: 9
Author(s): A. Perdih and M. Sollner Dolenc
Affiliation:
Keywords: Arylglycine derivatives, Dehydroamino Acid Derivatives, N-Methylation, USP methodology, Hydrogenation, Proline Derivatives
Abstract: The synthesis of unnatural α-amino acids is an area of research that has gained a lot of attention in recent years. The availability of synthetic methods for novel unnatural αamino acid derivatives and related compounds will be a critical point in the de novo design of molecules that mimic the conformation of the natural, active peptides. These molecules (peptidomimetics) are designed to display high receptor affinity and selectivity, in addition to enhanced bioavailability and metabolic stability. This review focuses on selected recent synthetic methodologies leading to unnatural α-amino acids including chiral catalysts that enable enantioselective synthesis and microwave-assisted synthesis. Solid phase synthesis and construction of organometallic αamino acids reveal the scope of influence that this field has in organic chemistry. Additionally, the article is aimed to provide a brief insight into the biosynthetic approaches to the synthesis of α-amino acid derivatives, and to give the reader an appreciation of the field.
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Cite this article as:
A. Perdih and M. Sollner Dolenc , Recent Advances in the Synthesis of Unnatural α-Amino Acids, Current Organic Chemistry 2007; 11 (9) . https://dx.doi.org/10.2174/138527207780831701
DOI https://dx.doi.org/10.2174/138527207780831701 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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