Current Drug Metabolism


Ming Hu
College of Pharmacy
University of Houston
Houston, TX

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Volume: 4 Issue: 5, October

Preface [Hot topic: Some Quantitative Issues Pertaining to Drug Metabolism and Drug-Drug Interactions (Guest Editor : Kenneth Bachmann)]

Volume:4   Issue: 5
Pp: iv-iv
Kenneth Bachmann
DOI: 10.2174/13892002103040500iv
Published on: 01 March, 2012

On the Estimation of Binding Affinity (ΔGbind) for Human P450 Substrates (Based on Km and KΔ Values)

Volume:4   Issue: 5
Pp: 331-340
David F.V. Lewis
DOI: 10.2174/1389200033489343
Published on: 01 March, 2012

Physiological Approaches to the Prediction of Drug-Drug Interactions in Study Populations

Volume:4   Issue: 5
Pp: 347-356
J. Y. Chien, M. A. Mohutsky and S. A. Wrighton
DOI: 10.2174/1389200033489307
Published on: 01 March, 2012

Application of a Convective-Dispersion Model to Predict In Vivo Hepatic Clearance from In Vitro Measurements Utilizing Cryopreserved Human Hepatocytes

Volume:4   Issue: 5
Pp: 357-369
Ryan Niro, James P. Byers, Ronald L. Fournier and Kenneth Bachmann
DOI: 10.2174/1389200033489334
Published on: 01 March, 2012

Relationship Between Extent of Inhibition and Inhibitor Dose: Literature Evaluation Based on the Metabolism and Transport Drug Interaction Database

Volume:4   Issue: 5
Pp: 371-380
R. H. Levy, H. Hachad, C. Yao and I. Ragueneau-Majlessi
DOI: 10.2174/1389200033489325
Published on: 01 March, 2012

Prediction of Human Drug Metabolizing Enzyme Induction

Volume:4   Issue: 5
Pp: 381-391
Dayna C. Mankowski and Sean Ekins
DOI: 10.2174/1389200033489352
Published on: 01 March, 2012

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

Volume:4   Issue: 5
Pp: 393-398
L. Z. Benet, C. L. Cummins and C. Y. Wu
DOI: 10.2174/1389200033489389
Published on: 01 March, 2012

A New Nonlinear Mixture Response Surface Paradigm for the Study of Synergism: A Three Drug Example

Volume:4   Issue: 5
Pp: 399-409
Donald B. White, Harry K. Slocum, Yseult Brun, Carol Wrzosek and William R. Greco
DOI: 10.2174/1389200033489316
Published on: 01 March, 2012

Drug Metabolism and Drug Interactions: Application and Clinical Value of In Vitro Models

Volume:4   Issue: 5
Pp: 423-459
Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt
DOI: 10.2174/1389200033489361
Published on: 01 March, 2012