Current Drug Metabolism


Ming Hu
College of Pharmacy
University of Houston
Houston, TX

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Volume: 13 Issue: 2, February

Editorial [Hot Topic: Cytochromes P450: Flexibility and Plasticity - Properties Determining Substrate Preferences (Guest Editors: Michal Otyepka and Pavel Anzenbacher)]

Volume:13   Issue: 2
Pp: 129-129
Pavel Anzenbacher and Michal Otyepka
DOI: 10.2174/138920012798918435
Published on: 01 March, 2012

Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450? open access plus

Volume:13   Issue: 2
Pp: 130-142
Michal Otyepka, Karel Berka and Pavel Anzenbacher
DOI: 10.2174/138920012798918372
Published on: 01 March, 2012

Multiple, Ligand-dependent Routes from the Active Site of Cytochrome P450 2C9

Volume:13   Issue: 2
Pp: 143-154
Vlad Cojocaru, Peter J. Winn and Rebecca C. Wade
DOI: 10.2174/138920012798918462
Published on: 01 March, 2012

The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants

Volume:13   Issue: 2
Pp: 155-166
Stephanie B.A. de Beer, Laura A.H. van Bergen, Karlijn Keijzer, Vanina Rea, Harini Venkataraman, Celia Fonseca Guerra, F. Matthias Bickelhaupt, Nico P.E. Vermeulen, Jan N.M. Commandeur and Daan P. Geerke
DOI: 10.2174/138920012798918471
Published on: 01 March, 2012

Plasticity of CYP2B Enzymes: Structural and Solution Biophysical Methods

Volume:13   Issue: 2
Pp: 167-176
P. Ross Wilderman and James R. Halpert
DOI: 10.2174/138920012798918417
Published on: 01 March, 2012

Dynamics and Hydration of the Active Sites of Mammalian Cytochromes P450 Probed by Molecular Dynamics Simulations

Volume:13   Issue: 2
Pp: 177-189
Tereza Hendrychova, Karel Berka, Veronika Navratilova, Pavel Anzenbacher and Michal Otyepka
DOI: 10.2174/138920012798918408
Published on: 01 March, 2012

Malleability and Versatility of Cytochrome P450 Active Sites Studied by Molecular Simulations

Volume:13   Issue: 2
Pp: 190-196
Chris Oostenbrink, Anita de Ruiter, Jozef Hritz and Nico Vermeulen
DOI: 10.2174/138920012798918453
Published on: 01 March, 2012

Identification of Selectivity Determinants in CYP Monooxygenases by Modelling and Systematic Analysis of Sequence and Structure

Volume:13   Issue: 2
Pp: 197-202
Alexander Seifert and Jurgen Pleiss
DOI: 10.2174/138920012798918444
Published on: 01 March, 2012

Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review

Volume:13   Issue: 2
Pp: 215-224
Pius Fasinu, Patrick J. Bouic and Bernd Rosenkranz
DOI: 10.2174/138920012798918426
Published on: 01 March, 2012

An insight into the Interaction between Clopidogrel and Proton Pump Inhibitors

Volume:13   Issue: 2
Pp: 225-235
Bhavik S. Shah, Sanjay A. Parmar, Shailaja Mahajan and Anita A. Mehta
DOI: 10.2174/138920012798918390
Published on: 01 March, 2012