Current Drug Metabolism


Ming Hu
University of Houston
College of Pharmacy
Houston, TX

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Open Access Articles

The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and Their Non-genotoxic Modes of Action open Access plus

Volume: 21  
Pp: 1-12
Jan Vondráček* and Miroslav Machala

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide open Access plus

Volume: 20   Issue: 8
Pp: 665-673
Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*

Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients open Access plus

Volume: 20   Issue: 7
Pp: 592-600
Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure open Access plus

Volume: 20   Issue: 5
Pp: 361-376
Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis open Access plus

Volume: 20   Issue: 4
Pp: 266-274
Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics open Access plus

Volume: 20   Issue: 2
Pp: 91-102
Li Di*

Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database open Access plus

Volume: 20   Issue: 2
Pp: 138-146
Zhi Liu, Xin He*, Lili Wang, Yunhua Zhang, Yue Hai and Rui Gao

Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model open Access plus

Volume: 20   Issue: 2
Pp: 103-113
Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*

Interpersonal Factors in the Pharmacokinetics and Pharmacodynamics of Voriconazole: Are CYP2C19 Genotypes Enough for Us to Make a Clinical Decision? open Access plus

Volume: 19   Issue: 14
Pp: 1152-1158
Xuefeng Zhong, Xunliang Tong, Yang Ju, Xiaoman Du and Yanming Li*

Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets open Access plus

Volume: 19   Issue: 12
Pp: 1012-1020
Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives open Access plus

Volume: 19   Issue: 10
Pp: 830-838
Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*

Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation open Access plus

Volume: 19   Issue: 6
Pp: 513-522
Meng Yu, Mouze Liu, Wei Zhang and Yingzi Ming*

Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future open Access plus

Volume: 19   Issue: 3
Pp: 170-191
Souvik Ghosh*, Yashpal Singh Malik and Nobumichi Kobayashi

Digestive Enzyme Supplementation in Gastrointestinal Diseases open Access plus

Volume: 17   Issue: 2
Pp: 187-193
Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines open Access plus

Volume: 16   Issue: 6
Pp: 412-426
Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti

Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide open Access plus

Volume: 15   Issue: 10
Pp: 953-965
Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum

A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics? open Access plus

Volume: 15   Issue: 6
Pp: 581-598
Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process open Access plus

Volume: 15   Issue: 2
Pp: 209-217
Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson

Prodrugs of Quercetin and Resveratrol: A Strategy Under Development open Access plus

Volume: 15   Issue: 1
Pp: 77-95
Lucia Biasutto and Mario Zoratti

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily open Access plus

Volume: 14   Issue: 10
Pp: 1059-1069
Tomas Smutny, Sridhar Mani and Petr Pavek

Pathways for Ligand Activated Nuclear Receptors to Unravel the Genomic Responses Induced by Hepatotoxicants open Access plus

Volume: 14   Issue: 10
Pp: 1022-1028
R.R.R. Fijten, D.G.J. Jennen and J.H.M. van Delft

Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering open Access plus

Volume: 14   Issue: 9
Pp: 946-968
M. Teresa Donato, Ramiro Jover and M. José Gómez-Lechón

Mechanism-based Inhibition of CYP450: An Indicator of Drug-induced Hepatotoxicity open Access plus

Volume: 14   Issue: 9
Pp: 921-945
Shan Feng and Xin He

Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics open Access plus

Volume: 14   Issue: 7
Pp: 764-790
Craig Giragossian, Tracey Clark, Nicole Piché-Nicholas and Christopher J. Bowman

Nanoparticle- and Liposome-carried Drugs: New Strategies for Active Targeting and Drug Delivery Across Blood-brain Barrier open Access plus

Volume: 14   Issue: 6
Pp: 625-640
Martha Leonor Pinzon-Daza, Ivana Campia, Joanna Kopecka, Ruth Garzon, Dario Ghigo and Chiara Rigant

Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development open Access plus

Volume: 14   Issue: 3
Pp: 324-340
T. Thanga Mariappan, Sandhya Mandlekar and Punit Marathe

Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity open Access plus

Volume: 14   Issue: 2
Pp: 167-173
Laura Cuzzolin

Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity open Access plus

Volume: 13   Issue: 10
Pp: 1464-1475
Jolanda S. van Leeuwen, Nico P.E. Vermeulen and J. Chris Vos

Peroxisomes, Peroxisomal Diseases, and the Hepatotoxicity Induced by Peroxisomal Metabolites open Access plus

Volume: 13   Issue: 10
Pp: 1401-1411
Ronald J.A. Wanders and Sacha Ferdinandusse

Isotopic Labeling of Metabolites in Drug Discovery Applications open Access plus

Volume: 13   Issue: 9
Pp: 1213-1225
Jacobo Iglesias, Lekha Sleno and Dietrich A. Volmer

Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates open Access plus

Volume: 13   Issue: 8
Pp: 1160-1173
M. Teresa Donato and M. Jose Gomez-Lechon

Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition open Access plus

Volume: 13   Issue: 8
Pp: 1145-1159
Toshiro Niwa and Hiroshi Yamazaki

Toxicological Profile of Therapeutic Nanodelivery Systems open Access plus

Volume: 13   Issue: 8
Pp: 1068-1086
Luis M. Bimbo, Leena Peltonen, Jouni Hirvonen and Helder A. Santos

Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics open Access plus

Volume: 13   Issue: 7
Pp: 947-950
Eugenia Kraynov, Martin E. Dowty, Odette Odette A. Fahmi and Owen Fields

Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture open Access plus

Volume: 13   Issue: 7
Pp: 930-937
Leslie J. Dickmann, Sonal K. Patel, Larry C. Wienkers and J. Greg Slatter

Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs open Access plus

Volume: 13   Issue: 6
Pp: 835-862
I. Hartyanszky, H. Kalasz, E. Adeghate, Zs. Gulyas, M. Y. Hasan, K. Tekes, A. Adem and P. Sotonyi

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings open Access plus

Volume: 13   Issue: 6
Pp: 695-720
G. Lu, K. Abduljalil, M. Jamei, T. N. Johnson, H. Soltani and A. Rostami-Hodjegan

Herb-Drug Interactions and Mechanistic and Clinical Considerations open Access plus

Volume: 13   Issue: 5
Pp: 640-651
Xiao-Wu Chen, Kevin B. Sneed, Si-Yuan Pan, Chuanhai Cao, Jagat R. Kanwar, Helen Chew and Shu- Feng Zhou

The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics open Access plus

Volume: 13   Issue: 5
Pp: 624-639
Yan Li, Jun Lu and James W. Paxton

Pharmacokinetics and Disposition of Various Drug Loaded Liposomes open Access plus

Volume: 13   Issue: 4
Pp: 372-395
Shuai Qian, Chenrui Li and Zhong Zuo

Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment open Access plus

Volume: 13   Issue: 3
Pp: 237-250
Hiroko Kodama, Chie Fujisawa and Wattanaporn Bhadhprasit

Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450? open Access plus

Volume: 13   Issue: 2
Pp: 130-142
Michal Otyepka, Karel Berka and Pavel Anzenbacher

Impact of Genetic Polymorphisms and Drug – Drug Interactions on Clopidogrel and Prasugrel Response Variability open Access plus

Volume: 11   Issue: 8
Pp: 667-677
V. Ancrenaz, Y. Daali, P. Fontana, M. Besson, C. Samer, P. Dayer and J. Desmeules

Systematic Evaluation of Dose Proportionality Studies in Clinical Pharmacokinetics open Access plus

Volume: 11   Issue: 6
Pp: 526-537
Yucheng Sheng, Yingchun He, Xiaohui Huang, Juan Yang, Kun Wang and Qingshan Zheng

Atypical Antipsychotic Metabolism and Excretion open Access plus

Volume: 11   Issue: 6
Pp: 516-525
J.J. Sheehan, J.K. Sliwa, J.C. Amatniek, A. Grinspan and C.M. Canuso

Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms open Access plus

Volume: 10   Issue: 4
Pp: 369-394
Sabina Passamonti, Michela Terdoslavich, Raffaella Franca, Andreja Vanzo, Federica Tramer, Enrico Braidot, Elisa Petrussa and Angelo Vianello

Biological Actions and Metabolism of Currently Used Pharmacological Agents for the Treatment of Congestive Heart Failure open Access plus

Volume: 10   Issue: 3
Pp: 206-219
Harjot K. Saini-Chohan and Grant M. Hatch

Arylamine N-Acetyltransferases in Mycobacteria open Access plus

Volume: 9   Issue: 6
Pp: 510-519
Edith Sim, James Sandy, Dimitrios Evangelopoulos, Elizabeth Fullam, Sanjib Bhakta, Isaac Westwood, Anna Krylova, Nathan Lack and Martin Noble

Lack of Interaction of the NMDA Receptor Antagonists Dextromethorphan and Dextrorphan with P-Glycoprotein open Access plus

Volume: 9   Issue: 2
Pp: 144-151
Jules Desmeules, M. Kanaan, Y. Daali and P. Dayer

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues open Access plus

Volume: 9   Issue: 2
Pp: 129-143
Petr Pavek and Zdenek Dvorak