Abstract
An increasing percentage of drug development candidates suffer from poor aqueous solubility which in turn often times leads to poor oral absorption. This poses significant challenges in formulation development to ensure bioavailability following oral administration. Traditional approaches to increase dissolution of immediate release formulations include incorporation of surfactants, reduction of particle size and liquid vehicle formulations. More recently, size reduction of either the active pharmaceutical ingredient (API) particle or the drug delivery system down to the sub-micron range appears as a new promising approach to further increase dissolution rates of hydrophobic molecules. Nanonization of either the API, in the form of nanosuspensions typically stabilized with surfactants, or of the formulation vehicle such as with the use of self-nanoemulsified drug delivery systems and solid lipid nanoparticles has been successfully utilized to increase in vivo dissolution. Such nanotechnology has demonstrated significant impact on enhancing the bioavailability of drug candidates and addressing issues such as inadequate exposure or food effect. The goal of this review is to summarize recent advances in the utilization of nanosuspensions, solid lipid nanoparticles or nanoemulsions in drug delivery of immediate release dosage forms.
Keywords: Nanoparticles, Bioavailability, Nanosuspensions, Nanoemulsions, Dissolution, Formulation
Current Nanoscience
Title: Application of Nanoparticles in Oral Delivery of Immediate Release Formulations
Volume: 3 Issue: 2
Author(s): Filippos Kesisoglou, Santipharp Panmai and Yunhui Wu
Affiliation:
Keywords: Nanoparticles, Bioavailability, Nanosuspensions, Nanoemulsions, Dissolution, Formulation
Abstract: An increasing percentage of drug development candidates suffer from poor aqueous solubility which in turn often times leads to poor oral absorption. This poses significant challenges in formulation development to ensure bioavailability following oral administration. Traditional approaches to increase dissolution of immediate release formulations include incorporation of surfactants, reduction of particle size and liquid vehicle formulations. More recently, size reduction of either the active pharmaceutical ingredient (API) particle or the drug delivery system down to the sub-micron range appears as a new promising approach to further increase dissolution rates of hydrophobic molecules. Nanonization of either the API, in the form of nanosuspensions typically stabilized with surfactants, or of the formulation vehicle such as with the use of self-nanoemulsified drug delivery systems and solid lipid nanoparticles has been successfully utilized to increase in vivo dissolution. Such nanotechnology has demonstrated significant impact on enhancing the bioavailability of drug candidates and addressing issues such as inadequate exposure or food effect. The goal of this review is to summarize recent advances in the utilization of nanosuspensions, solid lipid nanoparticles or nanoemulsions in drug delivery of immediate release dosage forms.
Export Options
About this article
Cite this article as:
Kesisoglou Filippos, Panmai Santipharp and Wu Yunhui, Application of Nanoparticles in Oral Delivery of Immediate Release Formulations, Current Nanoscience 2007; 3 (2) . https://dx.doi.org/10.2174/157341307780619251
DOI https://dx.doi.org/10.2174/157341307780619251 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phenolics and Terpenoids; the Promising New Search for Anthelmintics: A Critical Review
Mini-Reviews in Medicinal Chemistry An Overview of Innovations in Analysis and Beneficial Health Effects of Wine Polyphenols
Mini-Reviews in Medicinal Chemistry Thrombotic Microangiopathy and Occult Neoplasia
Cardiovascular & Hematological Disorders-Drug Targets Mucoadhesive Polymers for Delivery of Drugs to the Oral Cavity
Recent Patents on Drug Delivery & Formulation Antimicrobial, In Vitro and In Vivo Antineoplastic Activities, Mechanism of Action, Structural and Thermal Properties of a Small-Novel Pharmaceutical Organometallic Chelate
Mini-Reviews in Medicinal Chemistry Lipid-Based Drug Delivery Systems for Cancer Treatment
Current Drug Targets Therapeutic Targeting of CPT-11 Induced Diarrhea: A Case for Prophylaxis
Current Drug Targets Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective
Current Drug Metabolism Rutin-Phospholipid Complex: An Innovative Technique in Novel Drug Delivery System- NDDS
Current Drug Delivery Clinical Pharmacology of Novel Selective COX-2 Inhibitors
Current Pharmaceutical Design Current and Potential Use of Citrus Essential Oils
Current Organic Chemistry Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
Current Pharmaceutical Biotechnology Bone Target Radiotracers for Palliative Therapy of Bone Metastases
Current Medicinal Chemistry Vesicles: A Recently Developed Novel Carrier for Enhanced Topical Drug Delivery
Current Drug Delivery What Have We Learned from the Novel Human Cytochromes P450 Hidden in the Databases?
Current Genomics Nanotechnology as a Promising Strategy for Anticancer Drug Delivery
Current Drug Delivery A Brief Review of the Essential Role of Nanovehicles for Improving the Therapeutic Efficacy of Pharmacological Agents Against Tumours
Current Drug Delivery Chios Gum Mastic: A Review of its Biological Activities
Current Medicinal Chemistry Specific Active Immunotherapy of Cancer: Potential and Perspectives
Reviews on Recent Clinical Trials Safety and Proof-of-Concept Efficacy of Inhaled Drug Loaded Nano- and Immunonanoparticles in a c-Raf Transgenic Lung Cancer Model
Current Cancer Drug Targets