Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Accessed Articles

GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment

Volume: 22   Issue: 15
Pp: 1725-1737
Dilipkumar Pal, Souvik Mukherjee, In-Ho Song and Satish B. Nimse*
DOI: 10.2174/1389450122666210114095307

CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery

Volume: 22   Issue: 15
Pp: 1750-1759
Noushin R. Vandchali, Fatemeh Moadab, Eskandar Taghizadeh, Amir Tajbakhsh and Seyed M. Gheibihayat*
DOI: 10.2174/1389450122666210204203514

Recent Advances in Psoriasis Therapy: Trends and Future Prospects

Volume: 22   Issue: 15
Pp: 1760-1771
Atul Singh* and T.S. Easwari*
DOI: 10.2174/1389450122666210118103455

Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?

Volume: 22   Issue: 15
Pp: 1706-1715
Gionata Fiorino, Maria M. Estevinho, Diogo J.M. Lopes, Filippo Chersi, Mariangela Allocca, Miguel T. Souto, Silvio Danese and Fernando Magro*
DOI: 10.2174/1389450122666210203193817

Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy

Volume: 22   Issue: 15
Pp: 1738-1749
Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*
DOI: 10.2174/1389450122666210120143450

Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace

Volume: 22   Issue: 15
Pp: 1716-1724
Eduardo Fuentes, Andrés Trostchansky*, Lívia M. Reguengo, Mario R.M. Junior and Iván Palomo*
DOI: 10.2174/1389450122999210128180456

Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia

Volume: 22   Issue: 15
Pp: 1789-1798
Bhupendra Kaushik, Dilipkumar Pal* and Supriyo Saha
DOI: 10.2174/1389450122666210203192752

Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction

Volume: 22   Issue: 14
Pp: 1618-1628
Hayrettin O. Gulcan and Ilkay E. Orhan*
DOI: 10.2174/1389450122666210120144921

An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases

Volume: 22   Issue: 14
Pp: 1585-1595
Rashid Waseem, Anas Shamsi, Syed N. Kazim and Asimul Islam*
DOI: 10.2174/1389450121999201230204050

Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

Volume: 22   Issue: 14
Pp: 1596-1617
Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*
DOI: 10.2174/1389450121999201230204320

Aging of Brain Related with Mitochondrial Dysfunctions

Volume: 22   Issue: 14
Pp: 1668-1687
Vipin Dhote*, Prem Samundre, Aditya Ganeshpurkar and Aman Upaganlawar
DOI: 10.2174/1389450121999201209202247

Impaired Quality Control of Mitochondria Underlying the Pathogenesis of Alzheimer's Disease

Volume: 22   Issue: 14
Pp: 1578-1584
Md. Sahab Uddin*, Umme Tabassum Arobi Katha and Ghulam Md. Ashraf*
DOI: 10.2174/1389450122666210309105326

Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons

Volume: 22   Issue: 14
Pp: 1688-1703
Muthuraman Arunachalam*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet K. Singla, Seema Mudhol and Serva P. Muthukumar
DOI: 10.2174/1389450122666210222163528

GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma

Volume: 22   Issue: 13
Pp: 1485-1495
Sitansu S. Nanda, Md Imran Hossain, Heongkyu Ju and Dong Kee Yi*
DOI: 10.2174/1389450122666210204203950

Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19

Volume: 22   Issue: 13
Pp: 1536-1547
Amritpal Kaur, Gaurav Chaudhary, Pargat Singh, Sandeep Arora and Rajwinder Kaur*
DOI: 10.2174/1389450121999201228212842

Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure

Volume: 22   Issue: 13
Pp: 1568-1576
Ubaid Tariq, Shravan K. Uppulapu and Sanjay K. Banerjee*
DOI: 10.2174/1389450122666210224105430

Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as a New Lead for Treating Breast and Ovarian Cancer

Volume: 22   Issue: 13
Pp: 1548-1554
Phool Chandra*, Neetu Sachan and Dilipkumar Pal
DOI: 10.2174/1389450122666210203183351