Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Cited Article

TNF-α and IL-6: The Link between Immune and Bone System

Volume:21   Issue:3
Pp: 213-227
Tiantian Wang and Chengqi He*
DOI: 10.2174/1389450120666190821161259

Bioinformatics Approaches for Anti-cancer Drug Discovery

Volume:21   Issue:1
Pp: 3-17
Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*
DOI: 10.2174/1389450120666190923162203

Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies

Volume:21   Issue:9
Pp: 864-891
Devendra Kumar, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga and Bhupinder Kumar*
DOI: 10.2174/1389450121666200310115327

ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors

Volume:21   Issue:9
Pp: 892-901
Ana Luiza Ataide Carneiro de Paula Gonzaga , Vitória Andrade Palmeira , Thomas Felipe Silva Ribeiro , Larissa Braga Costa , Karla Emília de Sá Rodrigues and Ana Cristina Simões-e-Silva *
DOI: 10.2174/1389450121666200210124217

Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion

Volume:22   Issue:2
Pp: 192-201
Upinder Kaur, Sankha Shubhra Chakrabarti*, Bisweswar Ojha, Bhairav Kumar Pathak, Amit Singh, Luciano Saso and Sasanka Chakrabarti
DOI: 10.2174/1389450121666200924113243

The Therapeutic Potential of Chemokines in the Treatment of Chemotherapy- Induced Peripheral Neuropathy

Volume:21   Issue:3
Pp: 288-301
Lin Zhou, Luyao Ao, Yunyi Yan, Wanting Li, Anqi Ye, Yahui Hu*, Weirong Fang* and Yunman Li*
DOI: 10.2174/1389450120666190906153652

Antiviral Drug Targets of Single-Stranded RNA Viruses Causing Chronic Human Diseases

Volume:21   Issue:2
Pp: 105-124
Dhurvas Chandrasekaran Dinesh*, Selvaraj Tamilarasan, Kaushik Rajaram and Evžen Bouřa*
DOI: 10.2174/1389450119666190920153247

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

Volume:21   Issue:3
Pp: 258-278
Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*
DOI: 10.2174/1389450120666190821160730

The Therapeutic Potential of Quercetin in Parkinson’s Disease: Insights into its Molecular and Cellular Regulation

Volume:21   Issue:5
Pp: 509-518
Omid Reza Tamtaji, Tooba Hadinezhad, Maryam Fallah, Arash Rezaei Shahmirzadi, Mohsen Taghizadeh, Mohammad Behnam and Zatollah Asemi*
DOI: 10.2174/1389450120666191112155654

Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

Volume:22   Issue:3
Pp: 254-281
Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*
DOI: 10.2174/1389450121666201020154033

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease

Volume:21   Issue:13
Pp: 1371-1384
Vivek K. Sharma, Thakur G. Singh* and Shareen Singh
DOI: 10.2174/1389450121666200727104728

N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases

Volume:21   Issue:11
Pp: 1056-1067
Hui Zhong, Hui-Fang Tang and Yin Kai*
DOI: 10.2174/1389450121666200210125247