Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Accessed Articles

New Anti-VEGF Drugs in Ophthalmology

Volume: 21   Issue: 12
Pp: 1194-1200
Claudio Campa *
DOI: 10.2174/1389450121666200428101738

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

Volume: 21   Issue: 3
Pp: 258-278
Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*
DOI: 10.2174/1389450120666190821160730

N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases

Volume: 21   Issue: 11
Pp: 1056-1067
Hui Zhong, Hui-Fang Tang and Yin Kai*
DOI: 10.2174/1389450121666200210125247

Insight γ-Secretase: Structure, Function, and Role in Alzheimer’s Disease

Volume: 22   Issue: 12
Pp: 1376-1403
Suvadeep Mal, Udita Malik, Dilipkumar Pal* and Abhishek Mishra
DOI: 10.2174/1389450121999201230203709

Recent Advances in Nanotechnology-Based Drug Delivery Approaches for Alzheimer disease

Volume: 22   Issue: 12
Pp: 1404-1423
Ishnoor Kaur, Arun Kumar*, Tapan Behl and Dhruv Setia
DOI: 10.2174/1389450122999210104205018

Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance

Volume: 22   Issue: 12
Pp: 1346-1356
Dinesh S. Moirangthem and Laishram Surbala*
DOI: 10.2174/1389450121999201202110303

Potential Role of In vitro-In vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs

Volume: 22   Issue: 12
Pp: 1357-1375
Mohamed S.T.A. Azeeze*, Shanthi B. Santhosh, Murugesan S. Manjari and Subramania N. Meyyanathan
DOI: 10.2174/1389450121999201113110433

Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria

Volume: 22   Issue: 12
Pp: 1334-1345
Namita Sharma, Anil K. Chhillar*, Sweety Dahiya, Pooja Choudhary, Aruna Punia and Prity Gulia
DOI: 10.2174/1389450122666210120084406

Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes

Volume: 22   Issue: 12
Pp: 1424-1436
Hafsa Qadri, Abdul Haseeb Shah and Manzoor Mir*
DOI: 10.2174/1389450121666201228123212

TNF-α and IL-6: The Link between Immune and Bone System

Volume: 21   Issue: 3
Pp: 213-227
Tiantian Wang and Chengqi He*
DOI: 10.2174/1389450120666190821161259

Natural Products as Anticancer Agents

Volume: 22   Issue: 11
Pp: 1272-1287
Ruby Varghese and Yogesh B. Dalvi*
DOI: 10.2174/1389450121999201230204526

Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment

Volume: 22   Issue: 11
Pp: 1288-1316
Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair and Lekshmi R. Nath*
DOI: 10.2174/1389450122666210203194036

TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease

Volume: 22   Issue: 7
Pp: 760-769
Federica Furfaro*, Ludovico Alfarone, Daniela Gilardi, Carmen Correale, Mariangela Allocca, Gionata Fiorino, Marjorie Argollo, Alessandra Zilli, Eirini Zacharopoulou, Laura Loy, Giulia Roda and Silvio Danese
DOI: 10.2174/1389450122999210120205607

New Framework for the Discovery of PRC2 Inhibitors: Epigenetic Drugs

Volume: 22   Issue: 11
Pp: 1198-1206
Danishuddin, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*
DOI: 10.2174/1389450122666210215111744

A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2

Volume: 22   Issue: 11
Pp: 1232-1254
Mohana Das, Manish Kumar, Abhishek Jha, D.R. Madhukiran, Kanchan Bharti, Shomedeep Mondal and Brahmeshwar Mishra*
DOI: 10.2174/1389450121666201228122845

Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat

Volume: 22   Issue: 10
Pp: 1121-1128
Raghuvir Keni, Abinitha Sekhar, Karthik Gourishetti, Pawan G. Nayak, Manas Kinra, Nitesh Kumar, Rekha R. Shenoy, Anoop Kishore and Krishnadas Nandakumar*
DOI: 10.2174/1389450122666210120125945

Natural Bioactive Compounds as Emerging Therapeutic Molecules Against Breast Cancer: Emphasis on the Role of Phytoestrogens

Volume: 22   Issue: 11
Pp: 1255-1271
Anisha S. Malayil, Asifa K. Poothaadammal and Arunaksharan Narayanankutty*
DOI: 10.2174/1389450121999201109215341