Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Articles Ahead of Print

A Critical Review of Second-Generation Anti-EGFR Monoclonal Antibodies in Metastatic Colorectal Cancer

Daniel Sur*, Andrei Havasi, Alecsandra Gorzo and Claudia Burz

‘Treat to Target’ in Mild to Moderate Ulcerative Colitis: Evidence to Support this Strategy

Arianna Dal Buono, Giulia Roda, Marjorie Argollo, Kristine Paridaens, Laurent PeyrinBiroulet and Silvio Danese*

Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System

Sayed Md Mumtaz, Gautam Bhardwaj, Shikha Goswami, Rajiv Kumar Tonk, Ramesh K. Goyal and Faheem Hyder Pottoo*

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease

Vivek Kumar Sharma, Thakur Gurjeet Singh* and Shareen Singh

Therapeutic and Mechanistic Approaches of Tridax Procumbens Flavonoids for the Treatment of Osteoporosis

Md. Abdul Alim Al-Bari*, Showna Hossain, Ujjal Mia and Md. Abdullah Al Mamun

The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy

Shu Wang, Yuguang Guan and Tianfu Li*

Vaginitis: Review on drug resistance

Graziela Vargas Rigo and Tiana Tasca*

Neoadjuvant chemotherapy before radical cystectomy: why we must adhere?

Beppe Calò*, Michele Marchionni, Francesca Sangusedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio

Osteoblast-n-Osteoclast: Making headway to osteoporosis treatment

Malkiet Kaur, Manju Nagpal* and Manjinder Singh

To Explore the Potential Targets and Current Structure-based Design Strategies Utilizing co-crystallized Ligand to Combat HCV

Heena Tarannum, Bhumika Chauhan, Asmita Samadder, Harekrishna Roy and Sisir Nandi*

Past and Present Behçet’s Disease Animal Models

Jermilia Charles, Francis J. Castellino and Victoria A. Ploplis*

Precision Medicine in the Renin-Angiotensin System: Therapeutic Targets and Biological Variability

Guillermo Alberto Keller*, Maria Laura Ferreiros-Gago, Hector Di-Salvo and Guillermo Di Girolamo

Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article

Sina M. Matalqah, Khalid Aiedeh, Nizar M. Mhaidat, Karem H. Alzoubi*, Yasser Bustanji and Islam Hamad

How Targeted Therapy Influence Renal Surgery for Renal Cell Carcinoma

Francesco Greco*, Michele Marchioni, Francesco Esperto, Rocco Papalia, Luigi Schips and Roberto M Scarpa

Nanomedicine in Pancreatic Cancer: A New Hope for Treatment

Pablo Redruello, Gloria Perazzoli, Ana Cepero, Francisco Quiñonero, Cristina Mesas, Kevin Doello, Antonio Láinez-Ramos-Bossini, Mario Rivera-Izquierdo, Consolación Melguizo* and Jose Prados

Do drugs work for ΟΑΒ following prostate cancer surgery?

Vasileios Sakalis * and Anastasia Gkotsi

Drugs or Mechanical Devices for Obstructive LUTS?

Evangelos N. Symeonidis and Petros Sountoulides*

Fibroblast Growth Factor: Promising Target for Schizophrenia

Ali Talaei, Tahereh Farkhondeh and Fatemeh Forouzanfar*

Fluoroquinolones: Blessings Or Curses

Priyanka Prakash Majalekar* and Pramodkumar Jaykumar Shirote

A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches

Manaf AlMatar*, Osman Albarri, Essam A. Makky, Işıl Var and Fatih Köksal

Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu and Xiaolei Wang*

Intravesical Botox for Overactive Bladder: How to Minimize Complications and Manage Failures

Apostolos Apostolidis*, Efstathios Papaefstathiou and Sotirios Gatsos

Berberine Administration in Treatment of Colitis: A Review

Milad Ashrafizadeh, Masoud Najafi, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian*

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk

A Review on Emerging Drug Targets in Treatment of Schizophrenia

Hemen S. Ved and Gaurav M. Doshi*

Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications

Dickson Pius Wande, Qin Cui, Shijie Chen, Cheng Xu, Hui Xiong and Jing Yao*

PD-L1 Inhibitors for the Treatment of Prostate Cancer

Matteo Santoni*, Francesco Massari, Liang Cheng, Alessia Cimadamore, Marina Scarpelli, Rodolfo Montironi and Antonio Lopez-Beltran

Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease

Rhian Stavely, Raquel Abalo and Kulmira Nurgali*

Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance

Aditi Sharma, Avadh Biharee, Amit Kumar and Vikas Jaitak*

PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives

Thomas Gevaert*, Alessia Cimadamore, Rodolfo Montironi and Markus Eckstein

The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy

Agata Binienda, Sylwia Ziolkowska, Hans Hauge Ingvild and Maciej Salaga*

Nutritional Support and Probiotics as a Potential Treatment of IBD

Aleksandra Tarasiuk and Guido Eibl*

PD1/PD-L1 Axis in Uro-oncology

Kerstin Junker*, Markus Eckstein, Michelangelo Fiorentino and Rodolfo Montironi

Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment

Tingting Zhao, Zhe Wang , Zhilong Liu and Youhua Xu *

PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay

Alessia Cimadamore*, Francesco Massari , Matteo Santoni, Antonio Lopez-Beltran , Liang Cheng , Marina Scarpelli, Rodolfo Montironi and Holger Moch

Immunotherapy and Radiation Therapy in Renal Cell Carcinoma

Veronica Mollica, Matteo Santoni, Vincenzo Di Nunno, Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Rodolfo Montironi and Francesco Massari*

Challenges with Wound Infection Models in Drug Development

Sandeep K Shukla*, Ajay K Sharma, Vanya Gupta, Aman Kalonia and Priyanka Shaw

Withdrawal Notice: Preparation and Applications of Glyconanoparticles

Gangliang Huang*

Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms

Francesca Giunchi, Thomas Gevaert, Marina Scarpelli and Michelangelo Fiorentino*

Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer

Adrian Bartoszek, Jakub Fichna*, Aleksandra Tarasiuk, Agata Binienda, Adam Fabisiak, Julia B. Krajewska, Paula Mosińska, Karolina Niewinna and Maciej Salaga