Current Drug Targets

Editor-in-Chief

Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)

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Volume: 8 Issue: 2, February

Editorial [ Hot Topic: Highlights on Important Signaling Pathways as Drug Targets in Hematological Malignancies (Guest Editors: H. Serve and H.C. Hasselbalch) ]

Volume:8   Issue: 2
Pp: 203-203
Hubert Serve and Hans Carl Hasselbalch
DOI: 10.2174/138945007779940034
Published on: 01 March, 2012

Tyrosine Kinases as Therapeutic Targets in BCR-ABL Negative Chronic Myeloproliferative Disorders

Volume:8   Issue: 2
Pp: 205-216
Andreas Reiter, Christoph Walz and Nicholas C. P. Cross
DOI: 10.2174/138945007779940124
Published on: 01 March, 2012

Targeting the RAS Signaling Pathway in Malignant Hematologic Diseases

Volume:8   Issue: 2
Pp: 217-235
M. A. Morgan, A. Ganser and C. W. M. Reuter
DOI: 10.2174/138945007779940043
Published on: 01 March, 2012

Oncogenic Signaling in Acute Myeloid Leukemia

Volume:8   Issue: 2
Pp: 237-246
Christian H. Brandts, Wolfgang E. Berdel and Hubert Serve
DOI: 10.2174/138945007779940197
Published on: 01 March, 2012

The Mevalonate Pathway as a Therapeutic Target in the Ph-Negative Chronic Myeloproliferative Disorders

Volume:8   Issue: 2
Pp: 247-256
Hans Carl Hasselbalch and Caroline H. Riley
DOI: 10.2174/138945007779940133
Published on: 01 March, 2012

Vascular Endothelial Growth Factor and Its Receptor as Drug Targets in Hematological Malignancies

Volume:8   Issue: 2
Pp: 257-268
Torsten Kessler, Frauke Fehrmann, Ralf Bieker, Wolfgang E. Berdel and Rolf M. Mesters
DOI: 10.2174/138945007779940089
Published on: 01 March, 2012

Editorial [ Hot Topic: Current Drug Targets in Degenerative Joint Disease (Guest Editors: T. Aigner and E. Bartnik) ]

Volume:8   Issue: 2
Pp: 269-270
Thomas Aigner and Eckart Bartnik
DOI: 10.2174/138945007779940106
Published on: 01 March, 2012

Pathobiology of Osteoarthritis: Pathomechanisms and Potential Therapeutic Targets

Volume:8   Issue: 2
Pp: 271-282
H. I. Roach, T. Aigner, S. Soder, J. Haag and H. Welkerling
DOI: 10.2174/138945007779940160
Published on: 01 March, 2012

Cytokine Targeting in Osteoarthritis

Volume:8   Issue: 2
Pp: 283-292
Arjen B. Blom, Peter M. van der Kraan and Wim B. van den Berg
DOI: 10.2174/138945007779940179
Published on: 01 March, 2012

Molecular Targets in Osteoarthritis: Metalloproteinases and Their Inhibitors

Volume:8   Issue: 2
Pp: 293-303
P. S. Burrage and C. E. Brinckerhoff
DOI: 10.2174/138945007779940098
Published on: 01 March, 2012

Role of Cathepsin K in Normal Joints and in the Development of Arthritis

Volume:8   Issue: 2
Pp: 315-323
H. J. Salminen-Mankonen, J. Morko and E. Vuorio
DOI: 10.2174/138945007779940188
Published on: 01 March, 2012

Osteoarthritis: Aging of Matrix and Cells - Going for a Remedy

Volume:8   Issue: 2
Pp: 325-331
T. Aigner, J. Haag, J. Martin and J. Buckwalter
DOI: 10.2174/138945007779940070
Published on: 01 March, 2012

Cell Death and Apoptosis in Ostearthritic Cartilage

Volume:8   Issue: 2
Pp: 333-345
H. A. Kim and F. J. Blanco
DOI: 10.2174/138945007779940025
Published on: 01 March, 2012

Antioxidant to Treat Osteoarthritis: Dream or Reality?

Volume:8   Issue: 2
Pp: 347-357
Y. Henrotin and B. Kurz
DOI: 10.2174/138945007779940151
Published on: 01 March, 2012

Anabolic Factors in Degenerative Joint Disease

Volume:8   Issue: 2
Pp: 359-365
L. J. Sandell
DOI: 10.2174/138945007779940142
Published on: 01 March, 2012

In Vivo Osteoarthritis Target Validation Utilizing Genetically-Modified Mice

Volume:8   Issue: 2
Pp: 367-376
Sonya S. Glasson
DOI: 10.2174/138945007779940061
Published on: 01 March, 2012

Growth Plate Cartilage as Developmental Model in Osteoarthritis Research -Potentials and Limitations

Volume:8   Issue: 2
Pp: 377-385
T. Aigner and N. Gerwin
DOI: 10.2174/138945007779940052
Published on: 01 March, 2012