Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 6 Issue: 3, May

Editorial [Hot Topic: ErbB Family and Downstream Signal Transduction Pathways as Targets for Anticancer Therapy (Guest Editor: F. Caponigro)]

Volume:6   Issue: 3
Pp: 241-242
F. Caponigro
DOI: 10.2174/1389450053765851
Published on: 01 March, 2012

The ErbB Receptors and their Ligands in Cancer: An Overview

Volume:6   Issue: 3
Pp: 243-257
N. Normanno, C. Bianco, L. Strizzi, M. Mancino, M. R. Maiello, A. De Luca, F. Caponigro and D. S. Salomon
DOI: 10.2174/1389450053765879
Published on: 01 March, 2012

Small Molecules with EGFR-TK Inhibitor Activity

Volume:6   Issue: 3
Pp: 259-274
Joan Albanell and Pere Gascon
DOI: 10.2174/1389450053765888
Published on: 01 March, 2012

Monoclonal Antibodies Targeting the Epidermal Growth Factor Receptor

Volume:6   Issue: 3
Pp: 275-287
R. Bianco, G. Daniele, F. Ciardiello and G. Tortora
DOI: 10.2174/1389450053765842
Published on: 01 March, 2012

Antitumor Therapeutic Strategies Based on the Targeting of Epidermal Growth Factor-Induced Survival Pathways

Volume:6   Issue: 3
Pp: 289-300
P. Tagliaferri, P. Tassone, S. Blotta, C. Viscomi, F. Grillone, A. Budillon, M. Caraglia and S. Venuta
DOI: 10.2174/1389450053765897
Published on: 01 March, 2012

Isoprenylation of Intracellular Proteins as a New Target for the Therapy of Human Neoplasms: Preclinical and Clinical Implications

Volume:6   Issue: 3
Pp: 301-323
M. Caraglia, A. Budillon, P. Tagliaferri, M. Marra, A. Abbruzzese and F. Caponigro
DOI: 10.2174/1389450053765833
Published on: 01 March, 2012

Drugging Cell Cycle Kinases in Cancer Therapy

Volume:6   Issue: 3
Pp: 325-335
S. Blagden and J. de Bono
DOI: 10.2174/1389450053765824
Published on: 01 March, 2012

Multiple-Target Drugs: Inhibitors of Heat Shock Protein 90 and of Histone Deacetylase

Volume:6   Issue: 3
Pp: 337-351
A. Budillon, F. Bruzzese, E. Di Gennaro and M. Caraglia
DOI: 10.2174/1389450053765905
Published on: 01 March, 2012

Molecular Targets for Design of Novel Inhibitors to Circumvent Aminoglycoside Resistance

Volume:6   Issue: 3
Pp: 353-361
S. Jana and J. K. Deb
DOI: 10.2174/1389450053765860
Published on: 01 March, 2012

Colloidal Carriers for Ophthalmic Drug Delivery

Volume:6   Issue: 3
Pp: 363-371
Rubiana Mara Mainardes, Maria Cristina Cocenza Urban, Priscila Oliveira Cinto, Najeh Maissar Khalil, Marco Vinicius Chaud, Raul Cesar Evangelista and Maria Palmira Daflon Gremiao
DOI: 10.2174/1389450053765914
Published on: 01 March, 2012