Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 20 Issue: 1, January 2018

Pro-inflammatory Cytokines: Cellular and Molecular Drug Targets for Glucocorticoid-induced-osteoporosis via Osteocyte

Volume:20   Issue: 1
Pp: 1-15
Tiantian Wang, Xijie Yu* and Chengqi He*
DOI: 10.2174/1389450119666180405094046
Published on: 04 April, 2018

Melatonin as Potential Targets for Delaying Ovarian Aging

Volume:20   Issue: 1
Pp: 16-28
Yanzhou Yang*, Hoi-Hung Cheung, Cheng Zhang, Ji Wu and Wai-Yee Chan
DOI: 10.2174/1389450119666180828144843
Published on: 28 August, 2018

Lipid-based Nanocarriers for siRNA Delivery: Challenges, Strategies and the Lessons Learned from the DODAX: MO Liposomal System

Volume:20   Issue: 1
Pp: 29-50
Ana C.N. Oliveira, Joana Fernandes, Anabela Gonçalves, Andreia C. Gomes* and M.E.C.D. Real Oliveira*
DOI: 10.2174/1389450119666180703145410
Published on: 03 July, 2018

Toll-Like Receptor 4 and Heat-Shock Protein 70: Is it a New Target Pathway for Diabetic Vasculopathies?

Volume:20   Issue: 1
Pp: 51-59
Amanda Almeida de Oliveira, R. Clinton Webb and Kenia Pedrosa Nunes*
DOI: 10.2174/1389450119666180821105544
Published on: 20 August, 2018

Innovative Methodology in the Discovery of Novel Drug Targets in the Free-Living Amoebae

Volume:20   Issue: 1
Pp: 60-69
Abdul Mannan Baig*
DOI: 10.2174/1389450119666180426100452
Published on: 25 April, 2018

DNA Related Enzymes as Molecular Targets for Antiviral and Antitumoral Chemotherapy. A Natural Overview of the Current Perspectives

Volume:20   Issue: 1
Pp: 70-80
Hugo A. Garro* and Carlos R. Pungitore
DOI: 10.2174/1389450119666180426103558
Published on: 25 April, 2018

The Value of Biomarkers in Optimizing the Use of Immuno-oncologic Therapy

Volume:20   Issue: 1
Pp: 81-86
Carlos G. Ferreira, Andrea Nicolini*, Liliana Dalurzo, Stephen Stefani, Vanessa Teich and Natasha Leighl
DOI: 10.2174/1389450119666180911093143
Published on: 10 September, 2018

Exosomes in Therapy: Engineering, Pharmacokinetics and Future Applications

Volume:20   Issue: 1
Pp: 87-95
Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*
DOI: 10.2174/1389450119666180521100409
Published on: 20 May, 2018

Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus

Volume:20   Issue: 1
Pp: 96-110
Linghuan Li, Jiameng Qi and Hanbing Li*
DOI: 10.2174/1389450119666180726115805
Published on: 26 July, 2018

Acid-Sensing Ion Channels Structural Aspects, Pathophysiological Importance and Experimental Mutational Data Available Across Various Species to Target Human ASIC1

Volume:20   Issue: 1
Pp: 111-121
Anurag Singh Chauhan, Ganesh Chandra Sahoo*, Manas Ranjan Dikhit and Pradeep Das*
DOI: 10.2174/1389450119666180820103316
Published on: 19 August, 2018

Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research

Volume:20   Issue: 1
Pp: 122-143
Agnieszka Jankowska, Artur Świerczek, Elżbieta Wyska, Alicja Gawalska, Adam Bucki, Maciej Pawłowski and Grażyna Chłoń-Rzepa*
DOI: 10.2174/1389450119666180808105056
Published on: 07 August, 2018