Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 18 Issue: 12, September 2017

Editorial:Brain Hemorrhages and Future Management free to download

Volume:18   Issue: 12
Pp: 1315-1315
Gang Chen, Peter Lackner, Ihsan Solaroğlu and John H. Zhang
DOI: 10.2174/138945011812170824125820
Published on: 24 August, 2017

Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach

Volume:18   Issue: 12
Pp: 1316-1328
Tim Lekic, Damon Klebe, Pilar Pichon, Katarina Brankov, Sally Sultan, Devin McBride, Darlene Casel, Alhamza Al-Bayati, Yan Ding, Jiping Tang and John H. Zhang*
DOI: 10.2174/1389450117666160615100538
Published on: 14 June, 2016

Hematoma Expansion Following Intracerebral Hemorrhage: Mechanisms Targeting the Coagulation Cascade and Platelet Activation

Volume:18   Issue: 12
Pp: 1329-1344
Sherrefa R. Burchell, Jiping Tang and John H. Zhang*
DOI: 10.2174/1389450118666170329152305
Published on: 29 March, 2017

Early Hematoma Enlargement in Primary Intracerebral Hemorrhage

Volume:18   Issue: 12
Pp: 1345-1348
Du Cao, Qi Li, Peichun Fu, John Zhang and Jun Yang*
DOI: 10.2174/1389450118666170427151011
Published on: 27 April, 2017

Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage

Volume:18   Issue: 12
Pp: 1349-1357
Devin McBride, Jiping Tang and John H. Zhang*
DOI: 10.2174/1389450117666151209123857
Published on: 09 December, 2015

A Therapeutic Target of Cerebral Hemorrhagic Stroke: Matrix Metalloproteinase- 9

Volume:18   Issue: 12
Pp: 1358-1366
Baoqi Dang, Xiaochun Duan, Zhong Wang, Weichun He* and Gang Chen*
DOI: 10.2174/1389450118666170427151657
Published on: 27 April, 2017

Hematoma Expansion: Clinical and Molecular Predictors and Corresponding Pharmacological Treatment

Volume:18   Issue: 12
Pp: 1367-1376
Gaiqing Wang* and John Zhang*
DOI: 10.2174/1389450117666160712092224
Published on: 11 July, 2016

The Double Roles of the Prostaglandin E2 EP2 Receptor in Intracerebral Hemorrhage

Volume:18   Issue: 12
Pp: 1377-1385
Xu Luo, Qiquan Zhu, Jie Zhang, Qin Huang, Zongyi Xie* and Yuan Cheng
DOI: 10.2174/1389450117666151209122826
Published on: 09 December, 2015

The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke

Volume:18   Issue: 12
Pp: 1386-1391
Ozgur Oztop-Cakmak, Ihsan Solaroglu and Yasemin Gursoy-Ozdemir*
DOI: 10.2174/1389450117666160613104523
Published on: 12 June, 2016

Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases

Volume:18   Issue: 12
Pp: 1392-1398
Junwei Ma, Yibin Wang, Zhong Wang, Haiying Li, Zhimin Wang* and Gang Chen*
DOI: 10.2174/1389450118666170607104251
Published on: 06 June, 2017

Intraventricular Recombinant Tissue Plasminogen Activator in Treatment of Aneurysmal Intraventricular Hemorrhage: A Meta-Analysis

Volume:18   Issue: 12
Pp: 1399-1407
LiGen Shi, Liang Xu, LuFeng Shi, Dixon Brandon, Sheng Chen* and JianMin Zhang
DOI: 10.2174/1389450116666150907110815
Published on: 07 September, 2015

Neuroinflammation is Associated with Brain Extracellular TAU-Protein Release After Spontaneous Subarachnoid Hemorrhage

Volume:18   Issue: 12
Pp: 1408-1416
Alois Josef Schiefecker*, Anelia Dietmann, Ronny Beer, Bettina Pfausler, Peter Lackner, Mario Kofler, Marlene Fischer, Gregor Broessner, Florian Sohm, Miriam Mulino, Claudius Thomé, Christian Humpel, Erich Schmutzhard and Raimund Helbok
DOI: 10.2174/1389450117666160201111804
Published on: 31 January, 2016

Nosocomial Infections and Antimicrobial Treatment in Coiled Patients with Aneurysmal Subarachnoid Hemorrhage

Volume:18   Issue: 12
Pp: 1417-1423
Peter Lackner*, Christoph Mueller, Ronny Beer, Gregor Broessner, Marlene Fischer, Raimund Helbok, Alois Schiefecker, Erich Schmutzhard and Bettina Pfausler
DOI: 10.2174/1389450117666160401124426
Published on: 01 April, 2016

Early Brain Injury or Vasospasm? An Overview of Common Mechanisms

Volume:18   Issue: 12
Pp: 1424-1429
Basak Topkoru, Emrah Egemen, Ihsan Solaroglu* and John H. Zhang
DOI: 10.2174/1389450117666160905112923
Published on: 05 September, 2016

Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review

Volume:18   Issue: 12
Pp: 1430-1440
Marlene Fischer, Alois Schiefecker, Peter Lackner, Florian Frank, Raimund Helbok, Ronny Beer, Bettina Pfausler, Erich Schmutzhard and Gregor Broessner*
DOI: 10.2174/1389450117666160703161511
Published on: 03 July, 2016

Pharmacological Management Options to Prevent and Reduce Ischemic Hemorrhagic Transformation

Volume:18   Issue: 12
Pp: 1441-1459
Wing Mann Ho, Cesar Reis, Onat Akyol, Gokce Yilmaz Akyol, Richard Applegate II, Gary Stier, Robert Martin and John H. Zhang*
DOI: 10.2174/1389450117666160818115850
Published on: 18 August, 2016

Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System

Volume:18   Issue: 12
Pp: 1460-1465
Yibin Wang, Jiyuan Bu, Haitao Shen, Haiying Li, Zhong Wang* and Gang Chen
DOI: 10.2174/1389450117666151209120007
Published on: 09 December, 2015