Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Meet the Editorial Board Member free to download

Volume:17   Issue: 13
Pp: 1453-1453
Susan S. Smyth
DOI: 10.2174/138945011713160902180720

Editorial (Thematic Issue: Targeting Conformational Diseases with Natural and Pharmacological Chaperones) free to download

Volume:17   Issue: 13
Pp: 1454-1454
Angel Luis Pey
DOI: 10.2174/138945011713160902180912

Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

Volume:17   Issue: 13
Pp: 1455-1470
Tomas Majtan, Angel L. Pey, June Ereño-Orbea, Luis Alfonso Martínez-Cruz and Jan P. Kraus
DOI: 10.2174/1389450117666160302094910

Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules

Volume:17   Issue: 13
Pp: 1471-1481
Alfredo Ulloa-Aguirre and P. Michael Conn
DOI: 10.2174/1389450117666160307143345

Natural and Unnatural Compounds Rescue Folding Defects of Human Alanine: Glyoxylate Aminotransferase Leading to Primary Hyperoxaluria Type I

Volume:17   Issue: 13
Pp: 1482-1491
Elisa Oppici, Riccardo Montioli, Mirco Dindo and Barbara Cellini
DOI: 10.2174/1389450117666160302095254

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases

Volume:17   Issue: 13
Pp: 1492-1505
Adrián Velazquez-Campoy, Javier Sancho, Olga Abian and Sonia Vega
DOI: 10.2174/1389450117666160201110449

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

Volume:17   Issue: 13
Pp: 1506-1514
Angel L. Pey, Clare F. Megarity, Encarnación Medina-Carmona and David J. Timson
DOI: 10.2174/1389450117666160101121610

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open access plus

Volume:17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI: 10.2174/1389450117666160307143512

Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders

Volume:17   Issue: 13
Pp: 1527-1534
Bárbara J. Henriques, Tânia G. Lucas and Cláudio M. Gomes
DOI: 10.2174/1389450117666160813180812

Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target

Volume:17   Issue: 13
Pp: 1535-1544
Xiaoqing Guan, Yuning Hou, Fei Sun, Zhe Yang and Chunying Li
DOI: 10.2174/1389450117666151209120516

Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques

Volume:17   Issue: 13
Pp: 1545-1559
Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez and Taís Gratieri
DOI: 10.2174/1389450116666151019095121

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

Volume:17   Issue: 13
Pp: 1560-1576
Yuanchao Xie, Comfort Alicha Ogah, Xiangrui Jiang, Jianfeng Li and Jingshan Shen
DOI: 10.2174/1389450117666151209123751