Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 15 Issue: 14, December 2014

Editorial: New Strategies and Applications for Drugs Targeting EGFR and c-Met free to download

Volume:15   Issue: 14
Pp: 1261-1262
E. Giovannetti and L.G. Leon
DOI: 10.2174/1389450115666141107104844
Published on: 06 November, 2014

Clinical Pharmacology of EGFR/Met Inhibitors in Non-Small Cell Lung Cancer

Volume:15   Issue: 14
Pp: 1263-1272
Shigehiro Yagishita and Akinobu Hamada
DOI: 10.2174/1389450115666141110154838
Published on: 10 November, 2014

Epidermal Growth Factor Receptor Targeting in Non-Small Cell Lung Cancer: Revisiting Different Strategies Against the Same Target

Volume:15   Issue: 14
Pp: 1273-1283
Eduardo Castanon, Patricia Martin, Christian Rolfo, Juan P. Fusco, Lucia Ceniceros, Jairo Legaspi, Marta Santisteban and Ignacio Gil-Bazo
DOI: 10.2174/138945011514141216092935
Published on: 15 December, 2014

The Role of cMet in Non-Small Cell Lung Cancer Resistant to EGFRInhibitors: Did We Really Find the Target?

Volume:15   Issue: 14
Pp: 1284-1292
Francesco Passiglia, Nele Van Der Steen, Luis Raez, Patrick Pauwels, Ignacio Gil-Bazo, Edgardo Santos, Daniele Santini, Giovanni Tesoriere, Antonio Russo, Giuseppe Bronte, Karen Zwaenepoel, Federico Cappuzzo and Christian Rolfo
DOI: 10.2174/138945011514141216092739
Published on: 15 December, 2014

EGFR as a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies

Volume:15   Issue: 14
Pp: 1293-1301
Reza Nedaeinia, Amir Avan, Mostafa Manian, Rasoul Salehi and Majid Ghayour-Mobarhan
DOI: 10.2174/1389450115666141125123003
Published on: 25 November, 2014

Targeting c-MET/HGF Signaling Pathway in Upper Gastrointestinal Cancers: Rationale and Progress

Volume:15   Issue: 14
Pp: 1302-1311
Sharareh Gholamin, Hamid Fiuji, Mina Maftouh, Reza Mirhafez, Fatemeh Homaei Shandiz and Amir Avan
DOI: 10.2174/1389450115666141107105456
Published on: 06 November, 2014

Modulation of Signaling Enhances the Efficacy of the Combination of Satraplatin and Erlotinib

Volume:15   Issue: 14
Pp: 1312-1321
Abolfazl Avan, Auke D. Adema, Eveline K. Hoebe, Charlotte M. Huijts, Amir Avan, Gareth J. Veal, Rob Ruijtenbeek, Katja Wosikowski and Godefridus J. Peters
DOI: 10.2174/1389450115666141107110321
Published on: 06 November, 2014

The EGFR Pathway Regulates BCRP Expression in NSCLC Cells: Role of Erlotinib

Volume:15   Issue: 14
Pp: 1322-1330
Letizia Porcelli, Elisa Giovannetti, Yehuda G. Assaraf, Gerrit Jansen, George L. Scheffer, Ietje Kathman, Amalia Azzariti, Angelo Paradiso and Godefridus J. Peters
DOI: 10.2174/1389450116666141205145620
Published on: 05 December, 2014

Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells

Volume:15   Issue: 14
Pp: 1331-1340
Leticia G. Leon, Maria Gemelli, Rocco Sciarrillo, Amir Avan, Niccola Funel and Elisa Giovannetti
DOI: 10.2174/1389450116666141205160924
Published on: 05 December, 2014

The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy

Volume:15   Issue: 14
Pp: 1341-1353
Fiona H. Tan, Tracy L. Putoczki, Stanley S. Stylli and Rodney B. Luwor
DOI: 10.2174/1389450115666141120104146
Published on: 19 November, 2014

Acknowledgements to Reviewers:

Volume:15   Issue: 14
Pp: 1354-1355

DOI: 10.2174/138945011514141216100200
Published on: 15 December, 2014