Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 15 Issue: 1, January 2014

Editorial (Thematic Issue:Targeting Loss of Tumor Suppressors for Cancer Therapeutics)

Volume:15   Issue: 1
Pp: 1-1
Jenifer R. Prosperi and Kathleen Heppner Goss
DOI: 10.2174/138945011501140115104533
Published on: 14 January, 2014

Targeting Tumor Suppressor Networks for Cancer Therapeutics

Volume:15   Issue: 1
Pp: 2-16
Xuning Emily Guo, Bryan Ngo, Aram Sandaldjian Modrek and Wen-Hwa Lee
DOI: 10.2174/1389450114666140106095151
Published on: 05 January, 2014

Targeting the BRCA1/2 Tumor Suppressors

Volume:15   Issue: 1
Pp: 17-31
Eliot M. Rosen and Michael J. Pishvaian
DOI: 10.2174/1389450114666140106095432
Published on: 05 January, 2014

Targeting the LKB1 Tumor Suppressor

Volume:15   Issue: 1
Pp: 32-52
Rui-Xun Zhao and Zhi-Xiang Xu
DOI: 10.2174/1389450114666140106095811
Published on: 05 January, 2014

Translating Mismatch Repair Mechanism into Cancer Care

Volume:15   Issue: 1
Pp: 53-64
Christopher D. Heinen
DOI: 10.2174/1389450114666140106100128
Published on: 05 January, 2014

Therapeutic Targeting of Cancers with Loss of PTEN Function

Volume:15   Issue: 1
Pp: 65-79
Lloye M. Dillon and Todd W. Miller
DOI: 10.2174/1389450114666140106100909
Published on: 05 January, 2014

Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

Volume:15   Issue: 1
Pp: 80-89
Bo Hong, A. Pieter J. van den Heuvel, Varun V. Prabhu, Shengliang Zhang and Wafik S. El-Deiry
DOI: 10.2174/1389450114666140106101412
Published on: 05 January, 2014

Exploiting APC Function as a Novel Cancer Therapy

Volume:15   Issue: 1
Pp: 90-102
Alyssa C. Lesko, Kathleen H. Goss and Jenifer R. Prosperi
DOI: 10.2174/1389450114666131108155418
Published on: 08 November, 2013

The RNA-Dependent-RNA Polymerase, an Emerging Antiviral Drug Target for the Hendra Virus

Volume:15   Issue: 1
Pp: 103-113
Tony Velkov, Vincenzo Carbone, Jesmin Akter, Sivashangarie Sivanesan, Jian Li, Travis Beddoe and Glenn A. Marsh
DOI: 10.2174/1389450114888131204163210
Published on: 04 December, 2013

MDM2-p53 Interaction in Paediatric Solid Tumours: Preclinical Rationale, Biomarkers and Resistance

Volume:15   Issue: 1
Pp: 114-123
Giuseppe Barone, Deborah A. Tweddle, Jason M. Shohet, Louis Chesler, Lucas Moreno, Andrew DJ Pearson and Tom Van Maerken
DOI: 10.2174/13894501113149990194
Published on: 14 July, 2013

Oxycodone/Naloxone in the Management of Patients with Pain and Opioid–Induced Bowel Dysfunction

Volume:15   Issue: 1
Pp: 124-135
Wojciech Leppert
DOI: 10.2174/13894501113149990210
Published on: 29 August, 2013

Genomic Identification of Potential Targets Unique to Candida albicans for the Discovery of Antifungal Agents

Volume:15   Issue: 1
Pp: 136-149
Himanshu Tripathi, Suaib Luqman, Abha Meena and Feroz Khan
DOI: 10.2174/138945011501140115112242
Published on: 14 January, 2014