Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Volume: 12 Issue: 12, November

Editorial [Hot Topic: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy (Guest Editor: Marie Ranson)]

Volume:12   Issue: 12
Pp: 1709-1710
Marie Ranson
DOI: 10.2174/138945011797635894
Published on: 01 March, 2012

Rational Targeting of the Urokinase Receptor (uPAR): Development of Antagonists and Non-Invasive Imaging Probes

Volume:12   Issue: 12
Pp: 1711-1728
M. C. Kriegbaum, M. Persson, L. Haldager, W. Alpizar-Alpizar, B. Jacobsen, H. Gardsvoll, A. Kjaer and M. Ploug
DOI: 10.2174/138945011797635812
Published on: 01 March, 2012

Structural Basis for Therapeutic Intervention of uPA/uPAR System

Volume:12   Issue: 12
Pp: 1729-1743
Jacky Chi Ki Ngo, Longguang Jiang, Zhonghui Lin, Cai Yuan, Zhuo Chen, Xu Zhang, Haiyang Yu, Jundong Wang, Lin Lin and Mingdong Huang
DOI: 10.2174/138945011797635911
Published on: 01 March, 2012

uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy

Volume:12   Issue: 12
Pp: 1744-1760
Ida K. Lund, Martin Illemann, Tine Thurison, Ib J. Christensen and Gunilla Hoyer-Hansen
DOI: 10.2174/138945011797635902
Published on: 01 March, 2012

Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors

Volume:12   Issue: 12
Pp: 1761-1771
Maria Vincenza Carriero, Paola Franco, Giuseppina Votta, Immacolata Longanesi-Cattani, Maria Teresa Vento, Maria Teresa Masucci, Alessandro Mancini, Mario Caputi, Ingram Iaccarino and Maria Patrizia Stoppelli
DOI: 10.2174/138945011797635777
Published on: 01 March, 2012

Effects of Altered Plasminogen Activator Inhibitor-1 Expression on Cardiovascular Disease

Volume:12   Issue: 12
Pp: 1782-1789
Victoria A. Ploplis
DOI: 10.2174/138945011797635803
Published on: 01 March, 2012

Editorial [Hot Topic: Anti-Platelet Therapy (Guest Editor: Susan S. Smyth)]

Volume:12   Issue: 12
Pp: 1790-1791
Susan S. Smyth
DOI: 10.2174/138945011797635821
Published on: 01 March, 2012

Oral Antiplatelet Therapy for Acute Coronary Syndromes: Aspirin, P2Y12 Inhibition and Thrombin Receptor Antagonists

Volume:12   Issue: 12
Pp: 1805-1812
Alison L. Bailey and Charles L. Campbell
DOI: 10.2174/138945011797635830
Published on: 01 March, 2012

Current Issues with Glycoprotein IIb-IIIa Antagonists

Volume:12   Issue: 12
Pp: 1813-1820
David J. Schneider
DOI: 10.2174/138945011797635768
Published on: 01 March, 2012

Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy

Volume:12   Issue: 12
Pp: 1821-1830
Boris Bigalke, Margitta Elvers, Tanja Schonberger and Meinrad Gawaz
DOI: 10.2174/138945011797635867
Published on: 01 March, 2012

Bleeding and Acute Coronary Syndromes: Defining, Predicting, and Managing Risk and Outcomes

Volume:12   Issue: 12
Pp: 1831-1835
Sharif A. Halim and Sunil V. Rao
DOI: 10.2174/138945011797635876
Published on: 01 March, 2012

Role of Platelet Function Testing in Clinical Practice: Current Concepts and Future Perspectives

Volume:12   Issue: 12
Pp: 1836-1847
Dirk Sibbing, Robert A. Byrne and Adnan Kastrati
DOI: 10.2174/138945011797635786
Published on: 01 March, 2012

Progress of Antiplatelet Pharmacogenomics

Volume:12   Issue: 12
Pp: 1848-1858
Julie H. Oestreich
DOI: 10.2174/138945011797635849
Published on: 01 March, 2012

Big Science for Small Cells: Systems Approaches for Platelets

Volume:12   Issue: 12
Pp: 1859-1870
Stephen P. Holly and Leslie V. Parise
DOI: 10.2174/138945011797635795
Published on: 01 March, 2012