Current Drug Targets


Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Editor's Choice

The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy

Volume: 22   Issue: 9
Pp: 1021-1033
Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo
DOI: 10.2174/1389450122666210204204415

MiRNA, a New Treatment Strategy for Pulmonary Fibrosis

Volume: 22   Issue: 7
Pp: 793-802
Yanhong Liu, Hongguang Nie*, Yan Ding, Yapeng Hou, Kejun Mao and Yong Cui
DOI: 10.2174/1874609813666200928141822

Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review

Volume: 22   Issue: 6
Pp: 672-684
Md Belal Bin Heyat, Faijan Akhtar, M.A. Ansari, Asif Khan, Fahed Alkahtani, Haroon Khan* and Dakun Lai*
DOI: 10.2174/1389450121666201027125828

Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria

Volume: 22   Issue: 5
Pp: 555-572
Nabeelah Bibi Sadeer and Mohamad Fawzi Mahomoodally*
DOI: 10.2174/1389450121666200924113740

Anti-platelet Drug-loaded Targeted Technologies for the Effective Treatment of Atherothrombosis

Volume: 22   Issue: 4
Pp: 399-419
Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy and Ruckmani Kandasamy*
DOI: 10.2174/1389450121666201027125303

Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

Volume: 22   Issue: 3
Pp: 254-281
Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*
DOI: 10.2174/1389450121666201020154033

Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors

Volume: 22   Issue: 2
Pp: 241-251
Riccardo Mager, Giulia Roda, Mohammad Khaled Shalaby and Stefania Vetrano*
DOI: 10.2174/1389450121666201020160803

Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?

Volume: 22   Issue: 1
Pp: 14-21
Beppe Calò*, Michele Marchioni, Francesca Sanguedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio
DOI: 10.2174/1389450121666200802022150

The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials

Volume: 21   Issue: 16
Pp: 1733-1751
Adekunle Babajide Rowaiye, Titilayo Asala, Angus Nnamdi Oli*, Ikemefuna Chijioke Uzochukwu, Alex Akpa and Charles Okechukwu Esimone
DOI: 10.2174/1389450121666200910160929

Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

Volume: 21   Issue: 14
Pp: 1448-1455
Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu and Xiaolei Wang*
DOI: 10.2174/1389450121666200428102330

PD1/PD-L1 Axis in Uro-oncology

Volume: 21   Issue: 13
Pp: 1293-1300
Kerstin Junker*, Markus Eckstein, Michelangelo Fiorentino and Rodolfo Montironi
DOI: 10.2174/1389450121666200326123700

Anti-VEGF Treatment in Corneal Diseases

Volume: 21   Issue: 12
Pp: 1159-1180
Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia and Massimo Busin*
DOI: 10.2174/1389450121666200319111710

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Volume: 21   Issue: 11
Pp: 1084-1098
Fengqian Chen, Yunzhen Shi, Jinming Zhang and Qi Liu*
DOI: 10.2174/1389450121666200514222900

Biologic Therapy in Crohn’s Disease–What We Have Learnt So Far

Volume: 21   Issue: 8
Pp: 792-806
Kinga Majchrzak and Jakub Fichna*
DOI: 10.2174/1389450121666191218123203

Inflammation as a Therapeutic Target for Various Deadly Disorders: A Review

Volume: 21   Issue: 6
Pp: 582-588
Ashwani K. Dhingra* and Bhawna Chopra
DOI: 10.2174/1389450120666191204154115