Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

Volume: 22   Issue: 3
Pp: 254-281
Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*
DOI: 10.2174/1389450121666201020154033

Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors

Volume: 22   Issue: 2
Pp: 241-251
Riccardo Mager, Giulia Roda, Mohammad Khaled Shalaby and Stefania Vetrano*
DOI: 10.2174/1389450121666201020160803

Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?

Volume: 22   Issue: 1
Pp: 14-21
Beppe Calò*, Michele Marchioni, Francesca Sanguedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio
DOI: 10.2174/1389450121666200802022150

The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials

Volume: 21   Issue: 16
Pp: 1733-1751
Adekunle Babajide Rowaiye, Titilayo Asala, Angus Nnamdi Oli*, Ikemefuna Chijioke Uzochukwu, Alex Akpa and Charles Okechukwu Esimone
DOI: 10.2174/1389450121666200910160929

Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

Volume: 21   Issue: 14
Pp: 1448-1455
Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu and Xiaolei Wang*
DOI: 10.2174/1389450121666200428102330

PD1/PD-L1 Axis in Uro-oncology

Volume: 21   Issue: 13
Pp: 1293-1300
Kerstin Junker*, Markus Eckstein, Michelangelo Fiorentino and Rodolfo Montironi
DOI: 10.2174/1389450121666200326123700

Anti-VEGF Treatment in Corneal Diseases

Volume: 21   Issue: 12
Pp: 1159-1180
Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia and Massimo Busin*
DOI: 10.2174/1389450121666200319111710

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Volume: 21   Issue: 11
Pp: 1084-1098
Fengqian Chen, Yunzhen Shi, Jinming Zhang and Qi Liu*
DOI: 10.2174/1389450121666200514222900

Biologic Therapy in Crohn’s Disease–What We Have Learnt So Far

Volume: 21   Issue: 8
Pp: 792-806
Kinga Majchrzak and Jakub Fichna*
DOI: 10.2174/1389450121666191218123203

Inflammation as a Therapeutic Target for Various Deadly Disorders: A Review

Volume: 21   Issue: 6
Pp: 582-588
Ashwani K. Dhingra* and Bhawna Chopra
DOI: 10.2174/1389450120666191204154115

An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes

Volume: 21   Issue: 5
Pp: 445-457
Ping Wu, Zhenyu Liu, Xiaohong Jiang and Hao Fang*
DOI: 10.2174/1389450120666191031104653

Study of Monocytes/Macrophages Stimuli as the Targets of Treating Inflammatory Bone Diseases

Volume: 21   Issue: 4
Pp: 338-343
Yuan Liu, Yang Cao, Wanli Smith, Baorong He and Liang Yan*
DOI: 10.2174/1389450120666191015211737

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

Volume: 21   Issue: 3
Pp: 258-278
Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*
DOI: 10.2174/1389450120666190821160730

Angiotensin Type 1 Receptor Blockers in Heart Failure

Volume: 21   Issue: 2
Pp: 125-131
Khuraijam Dhanachandra Singh* and Sadashiva S. Karnik*
DOI: 10.2174/1389450120666190821152000

Circulating Exosomes and Their Role in Stroke

Volume: 21   Issue: 1
Pp: 89-95
Reza Jafarzadeh-Esfehani, Mohammad Soudyab, Seyed Mostafa Parizadeh, Mohammad Ehsan Jaripoor, Payam Sasan Nejad, Mohammad Shariati and Ariane Sadr Nabavi*
DOI: 10.2174/1389450120666190821153557

Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

Volume: 20   Issue: 16
Pp: 1624-1635
Jobin Jose, Aaron Mathew Thomas, Darewin Mendonsa, Mohammad M. Al-Sanea, Md. Sahab Uddin, Della Grace Thomas Parambi, R Narayana Charyulu and Bijo Mathew*
DOI: 10.2174/1389450120666190729121747

Anti-TNF and Postoperative Complications in Abdominal Crohn's Disease Surgery

Volume: 20   Issue: 13
Pp: 1339-1348
Takayuki Yamamoto*, Fabio Vieira Teixeira, Rogerio Saad-Hossne, Paulo Gustavo Kotze and Silvio Danese
DOI: 10.2174/1389450120666190404144048

Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: A Review

Volume: 20   Issue: 12
Pp: 1264-1280
Sok Kuan Wong, Kok-Yong Chin and Soelaiman Ima-Nirwana*
DOI: 10.2174/1389450120666190405172524

Diversity of Bacteria and Bacterial Products as Antibiofilm and Antiquorum Sensing Drugs Against Pathogenic Bacteria

Volume: 20   Issue: 11
Pp: 1156-1179
Fazlurrahman Khan, Sandra Folarin Oloketuyi and Young-Mog Kim*
DOI: 10.2174/1389450120666190423161249

The Use of Naltrexone in Dermatology. Current Evidence and Future Directions

Volume: 20   Issue: 10
Pp: 1058-1067
Mariusz Sikora*, Adriana Rakowska, Małgorzata Olszewska and Lidia Rudnicka
DOI: 10.2174/1389450120666190318121122

Developing Practical Therapeutic Strategies that Target Protein SUMOylation open access plus

Volume: 20   Issue: 9
Pp: 960-969
Olivia F. Cox and Paul W. Huber*
DOI: 10.2174/1389450119666181026151802

Targeting Water in the Brain: Role of Aquaporin-4 in Ischemic Brain Edema

Volume: 20   Issue: 7
Pp: 748-755
Muyassar Mamtilahun, Guanghui Tang, Zhijun Zhang, Yongting Wang, Yaohui Tang* and Guo-Yuan Yang*
DOI: 10.2174/1389450120666190214115309

Estrogen Receptor Alpha and its Ubiquitination in Breast Cancer Cells

Volume: 20   Issue: 6
Pp: 690-704
Angeles C. Tecalco-Cruz*, Josué O. Ramírez-Jarquín and Eduardo Cruz-Ramos
DOI: 10.2174/1389450119666181015114041

Understanding Membrane Protein Drug Targets in Computational Perspective

Volume: 20   Issue: 5
Pp: 551-564
Jianting Gong, Yongbing Chen, Feng Pu, Pingping Sun, Fei He, Li Zhang, Yanwen Li*, Zhiqiang Ma* and Han Wang*
DOI: 10.2174/1389450120666181204164721

Influence of Ultrafine Particles Exposure on Asthma Exacerbation in Children: A Meta-Analysis

Volume: 20   Issue: 4
Pp: 412-420
Qinyuan Li, Qian Yi, Lin Tang, Siying Luo, Yuan Tang, Guangli Zhang and Zhengxiu Luo*
DOI: 10.2174/1389450119666180829114252

A Review on Quantum Dots: Synthesis to In- silico Analysis as Next Generation Antibacterial Agents

Volume: 20   Issue: 3
Pp: 255-262
Sounik Manna, Munmun Ghosh, Ranadhir Chakraborty, Sudipto Ghosh and Santi M. Mandal*
DOI: 10.2174/1389450119666180731142423

Gut Mycobiota and Fungal Metabolites in Human Homeostasis

Volume: 20   Issue: 2
Pp: 232-240
Izabella Mogilnicka and Marcin Ufnal *
DOI: 10.2174/1389450119666180724125020

Genetic Molecular Subtypes in Optimizing Personalized Therapy for Metastatic Colorectal Cancer

Volume: 19   Issue: 15
Pp: 1731-1737
Marcin Włodarczyk*, Jakub Włodarczyk, Paweł Siwiński, Aleksandra Sobolewska-Włodarczyk and Jakub Fichna
DOI: 10.2174/1389450119666180803122744

Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation

Volume: 19   Issue: 14
Pp: 1683-1695
Sanjeev Raghuwanshi, Swati Dahariya, Ravinder Kandi, Usha Gutti, Ram Babu Undi, Durga Shankar Sharma, Itishri Sahu, Narasaiah Kovuru, Nagendra Sastry Yarla, Raja Gopal Venakata Saladi and Ravi Kumar Gutti*
DOI: 10.2174/1389450118666171122141821

The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis

Volume: 19   Issue: 12
Pp: 1424-1430
Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid and Ima-Nirwana Soelaiman
DOI: 10.2174/1389450118666170925154428

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature

Volume: 19   Issue: 11
Pp: 1276-1288
Dianaly T. Au, Allison L. Arai, William E. Fondrie, Selen C. Muratoglu* and Dudley K. Strickland*
DOI: 10.2174/1389450119666180511162048

The Role of DNA Repair Pathways in AML Chemosensitivity

Volume: 19   Issue: 10
Pp: 1205-1219
Elizabeth A. Pearsall, Lisa F. Lincz and Kathryn A. Skelding*
DOI: 10.2174/1389450119666180110093713

Ubiquitin and ubiquitin-like proteins in cardiac disease and protection

Volume: 19   Issue: 9
Pp: 989-1002
Jie Li, John A. Johnson and Huabo Su*
DOI: 10.2174/1389450117666151209114608

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

Volume: 19   Issue: 6
Pp: 651-662
Yuanyuan Cheng and Jianhui Rong*
DOI: 10.2174/1389450118666171031115025

Zoledronic Acid: Pleiotropic Anti-Tumor Mechanism and Therapeutic Outlook for Osteosarcoma

Volume: 19   Issue: 5
Pp: 409-421
Zhengxiao Ouyang, Haowei Li, Zanjing Zhai, Jiake Xu, Crispin R. Dass, An Qin* and Kerong Dai*
DOI: 10.2174/1573399811666150615145409

Smart Triggered Release in Controlled Drug Delivery

Volume: 19   Issue: 4
Pp: 318-327
Paul Catalin Balaure, Dragos Gudovan* and Iulia Alexandra Gudovan
DOI: 10.2174/1389450117666160401125034

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Volume: 19   Issue: 2
Pp: 111-127
Trevor L. Kane, Katelyn E. Carothers and Shaun W. Lee*
DOI: 10.2174/1389450117666161128123536

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Volume: 19   Issue: 1
Pp: 38-54
Palrasu Manikandan and Siddavaram Nagini*
DOI: 10.2174/1389450118666170125144557

Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury

Volume: 18   Issue: 15
Pp: 1733-1745
Jipeng Ma, Lifang Yang, Yanyan Ma, Xiaowu Wang, Jun Ren* and Jian Yang*
DOI: 10.2174/1389450116666151019102052

The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators

Volume: 18   Issue: 14
Pp: 1653-1663
Chiranjib Chakraborty, Seong Lin Teoh and Srijit Das*
DOI: 10.2174/1389450117666160527142321

The Molecular Concept of Atheromatous Plaques

Volume: 18   Issue: 11
Pp: 1250-1258
Zar Chi Thent, Chiranjib Chakraborty, Pasuk Mahakkanukrauh, Nik Nik Ritza Kosai Nik Mahmood, Reynu Rajan and Srijit Das*
DOI: 10.2174/1389450117666160502151600

Epigenetic Effects of Environmental Chemicals on Reproductive Biology

Volume: 18   Issue: 10
Pp: 1116-1124
Maria Strazzullo* and Maria Rosaria Matarazzo
DOI: 10.2174/1389450117666161025100125

Inflammasome in Dendritic Cells Immunobiology: Implications to Diseases and Therapeutic Strategies

Volume: 18   Issue: 9
Pp: 1003-1018
Isabel Ferreira, Joana Liberal, Joao D Martins, Ana Silva, Bruno Miguel Neves* and Maria Teresa Cruz*
DOI: 10.2174/1389450117666160921144830

Docking Studies for Multi-Target Drugs

Volume: 18   Issue: 5
Pp: 592-604
Luciana Scotti, Francisco J.B. Mendonca Junior, Hamilton M. Ishiki, Frederico F. Ribeiro, Rajeev K. Singla, Jose M. Barbosa Filho, Marcelo S. Da Silva and Marcus T. Scotti
DOI: 10.2174/1389450116666150825111818

Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers

Volume: 18   Issue: 3
Pp: 281-295
Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sebastien Delisle, Kai-Xun Hu and Anthony D. Sung
DOI: 10.2174/1389450116666150304103849

New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain

Volume: 18   Issue: 2
Pp: 160-173
Pere Boadas-Vaello, Jose Miguel Vela and Enrique Verdu
DOI: 10.2174/1389450117666160527142423

Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment

Volume: 18   Issue: 1
Pp: 35-55
Gabriella Misso, Mayra Rachele Zarone, Anna Grimaldi, Maria Teresa Di Martino, Angela Lombardi, Hiromichi Kawasaki, Paola Stiuso, Pierfrancesco Tassone, Pierosandro Tagliaferri and Michele Caraglia
DOI: 10.2174/1389450117666160606104208

Astrocytes: Adhesion Molecules and Immunomodulation

Volume: 17   Issue: 16
Pp: 1871-1881
Shane Liddelow and Daniel Hoyer
DOI: 10.2174/1389450117666160101120703

The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy

Volume: 17   Issue: 15
Pp: 1747-1754
Michalis Mastri, Spencer Rosario, Amanda Tracz, Robin E. Frink, Rolf A. Brekken and John M. L. Ebos
DOI: 10.2174/1389450117666151209123544

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI: 10.2174/1389450117666160307143512

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Volume: 17   Issue: 12
Pp: 1341-1349
Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward and Josephine M. Forbes
DOI: 10.2174/1389450116666150727114410

Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators

Volume: 17   Issue: 10
Pp: 1206-1223
Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira and Teresa Sousa
DOI: 10.2174/1389450117666160101121135

Emerging Immunotargets in Metastatic Renal Cell Carcinoma

Volume: 17   Issue: 7
Pp: 771-776
John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Stefano Cascinu, Rodolfo Montironi and Moch Holger
DOI: 10.2174/1389450117666151209115753

Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses

Volume: 17   Issue: 6
Pp: 630-639
Rita F. Santos, Liliana Oliveira and Alexandre M. Carmo
DOI: 10.2174/1389450116666150531152439

Roles of Apoptosis and Cellular Senescence in Cancer and Aging

Volume: 17   Issue: 4
Pp: 405-415
Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
DOI: 10.2174/1389450116666150202155915

Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate Cancer

Volume: 17   Issue: 3
Pp: 276-289
Pavlos Msaouel, Jose Nahun Galeas, Alejandro Recio Boiles, Ramiro Rancier Ruiz and Michael Koutsilieris
DOI: 10.2174/1389450116666150420143932

Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ? promotion: free to download

Volume: 17   Issue: 1
Pp: 54-64
Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria
DOI: 10.2174/1389450116666150630110329

Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors

Volume: 16   Issue: 14
Pp: 1634-1644
Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
DOI: 10.2174/1389450116666150113121733

Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

Volume: 16   Issue: 10
Pp: 1088-1093
Mitchell A. Sullivan, Brooke E. Harcourt, Ping Xu, Josephine M. Forbes and Robert G. Gilbert
DOI: 10.2174/1389450116666150727123115

Opportunities for Photoacoustic-Guided Drug Delivery

Volume: 16   Issue: 6
Pp: 571-581
Jun Xia, Chulhong Kim and Jonathan F. Lovell
DOI: 10.2174/1389450116666150707100328

Molecular Pathophysiology of Priapism: Emerging Targets

Volume: 16   Issue: 5
Pp: 474-483
Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett
DOI: 10.2174/1389450115666141111111842

Cardiovascular Complications in Inflammatory Bowel Disease

Volume: 16   Issue: 3
Pp: 181-188
Rudolf Schicho, Gunther Marsche and Martin Storr
DOI: 10.2174/1389450116666150202161500

Molecular Foundations for Personalized Therapy in Prostate Cancer

Volume: 16   Issue: 2
Pp: 103-114
Kurt W. Fisher, Rodolfo Montironi, Antonio Lopez Beltran, Holger Moch, Lisha Wang, Marina Scarpelli, Sean R. Williamson, Michael O. Koch and Liang Cheng
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Affinity-Based Methods in Drug-Target Discovery promotion: free to download

Volume: 16   Issue: 1
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Gabriela Rylova, Tomas Ozdian, Lakshman Varanasi, Miroslav Soural, Jan Hlavac, Dusan Holub, Petr Dzubak and Marian Hajduch
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Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells

Volume: 15   Issue: 14
Pp: 1331-1340
Leticia G. Leon, Maria Gemelli, Rocco Sciarrillo, Amir Avan, Niccola Funel and Elisa Giovannetti
DOI: 10.2174/1389450116666141205160924

Targeting SUMOylation Cascade for Diabetes Management

Volume: 15   Issue: 12
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Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanrama Ramkumar, Shanmugakani Rathinakumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru and Ramasamy Paulmurugan
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