Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Open Access Articles

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis open Access plus

Volume: 20   Issue: 16
Pp: 1695-1701
Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino

Current Understanding of Group A Streptococcal Biofilms open Access plus

Volume: 20   Issue: 9
Pp: 982-993
Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets open Access plus

Volume: 20   Issue: 9
Pp: 970-981
Benjamin J. Buckley*, Umar Ali, Michael J. Kelso and Marie Ranson

Developing Practical Therapeutic Strategies that Target Protein SUMOylation open Access plus

Volume: 20   Issue: 9
Pp: 960-969
Olivia F. Cox and Paul W. Huber*

The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain open Access plus

Volume: 20   Issue: 9
Pp: 953-959
Manuel Yepes*

Saccharomyces cerevisiae (Baker’s Yeast) as an Interfering RNA Expression and Delivery System open Access plus

Volume: 20   Issue: 9
Pp: 942-952
Molly Duman-Scheel*

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues open Access plus

Volume: 20   Issue: 8
Pp: 808-822
Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch

Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy open Access plus

Volume: 20   Issue: 4
Pp: 431-443
Gustavo H. Oliveira-Paula and Jose E. Tanus-Santos*

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD open Access plus

Volume: 19   Issue: 16
Pp: 1882-1896
Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm open Access plus

Volume: 19   Issue: 11
Pp: 1265-1275
Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review open Access plus

Volume: 19   Issue: 9
Pp: 1095-1107
Nur Fathiah Mohd Radzi, Noor Akmal Shareela Ismail and Ekram Alias*

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook open Access plus

Volume: 18   Issue: 9
Pp: 1095-1103
Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*

Aspirin Intolerance: Experimental Models for Bed-to-Bench open Access plus

Volume: 17   Issue: 16
Pp: 1963-1970
Masamichi Yamashita

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms open Access plus

Volume: 17   Issue: 13
Pp: 1515-1526
Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez

Structural and Functional Aspects of Class A Carbapenemases open Access plus

Volume: 17   Issue: 9
Pp: 1006-1028
Thierry Naas, Laurent Dortet and Bogdan I. Iorga

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy open Access plus

Volume: 17   Issue: 8
Pp: 954-970
Mark Walsh, Stephanie Fritz, Daniel Hake, Michael Son, Sarah Greve, Manar Jbara, Swetha Chitta, Braxton Fritz, Adam Miller, Mary K Bader, Jonathon McCollester, Sophia Binz, Alyson Liew-Spilger, Scott Thomas, Anton Crepinsek, Faisal Shariff, Victoria Ploplis and Francis J. Castellino

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance open Access plus

Volume: 17   Issue: 2
Pp: 164-177
Gabriela Nestal de Moraes, Laura Bella, Stefania Zona, Matthew J. Burton and Eric W.-F. Lam

Biologics for Extraintestinal Manifestations of IBD open Access plus

Volume: 15   Issue: 11
Pp: 1064-1073
Stephan R. Vavricka, Michael Scharl, Martin Gubler and Gerhard Rogler

Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis open Access plus

Volume: 14   Issue: 11
Pp: 1347-1356
Nian-Hua Ding, Jian Jian Li and Lun-Quan Sun

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function open Access plus

Volume: 14   Issue: 11
Pp: 1262-1276
Frederick Rohan Walker, Michael Nilsson and Kimberley Jones

Serum S100B Represents a New Biomarker for Mood Disorders open Access plus

Volume: 14   Issue: 11
Pp: 1237-1248
Matthias L. Schroeter, Julia Sacher, Johann Steiner, Peter Schoenknecht and Karsten Mueller

Perioperative Handling of Antiplatelet Drugs. A Critical Appraisal open Access plus

Volume: 14   Issue: 8
Pp: 880-888
Matteo Nicola Dario Di Minno, Marco Milone, Pasquale Mastronardi, Pasquale Ambrosino, Alessandro Di Minno, Alessandro Parolari, Elena Tremoli and Domenico Prisco

Oxidation Inhibits Iron-Induced Blood Coagulation open Access plus

Volume: 14   Issue: 1
Pp: 13-19
Etheresia Pretorius, Janette Bester, Natasha Vermeulen and Boguslaw Lipinski

Tissue-Based Approaches to Study Pharmacodynamic Endpoints in Early Phase Oncology Clinical Trials open Access plus

Volume: 13   Issue: 12
Pp: 1525-1534
Joo Ern Ang, Stan Kaye and Udai Banerji

Overcoming Drug Resistance and Treating Advanced Prostate Cancer open Access plus

Volume: 13   Issue: 10
Pp: 1308-1323
Julius Semenas, Cinzia Allegrucci, Stephen A. Boorjian, Nigel P. Mongan and Jenny Liao Persson

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation open Access plus

Volume: 13   Issue: 6
Pp: 744-752
Vincenzo Corbo, Giampaolo Tortora and Aldo Scarpa

Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides open Access plus

Volume: 13   Issue: 4
Pp: 471-482
Yuan-Ping Pang, Stephen Brimijoin, David W. Ragsdale, Kun Yan Zhu and Robert Suranyi

Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target open Access plus

Volume: 13   Issue: 3
Pp: 352-372
Andrew Robinson, Rebecca J. Causer and Nicholas E. Dixon

Vaccines and Other Immunological Approaches for Cancer Immunoprevention open Access plus

Volume: 12   Issue: 13
Pp: 1957-1973
Pier-Luigi Lollini, Giordano Nicoletti, Lorena Landuzzi, Federica Cavallo, Guido Forni, Carla De Giovanni and Patrizia Nanni

The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens open Access plus

Volume: 12   Issue: 7
Pp: 942-954
Salvatore Bozzaro and Ludwig Eichinger

Host-Pathogen Interactions Made Transparent with the Zebrafish Model open Access plus

Volume: 12   Issue: 7
Pp: 1000-1017
Annemarie H. Meijer and Herman P. Spaink

Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1 open Access plus

Volume: 12   Issue: 5
Pp: 724-736
L. H. Jiang, N. Gamper and D. J. Beech

The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival open Access plus

Volume: 12   Issue: 4
Pp: 556-562
Arash S. Saffar, Heather Ashdown and Abdelilah S. Gounni

Heme Oxygenase-1 in Tumor Biology and Therapy open Access plus

Volume: 11   Issue: 12
Pp: 1551-1570
Halina Was, Jozef Dulak and Alicja Jozkowicz

Involvement of the Toxic AGEs (TAGE)-RAGE System in the Pathogenesis of Diabetic Vascular Complications: A Novel Therapeutic Strategy open Access plus

Volume: 11   Issue: 11
Pp: 1468-1482
Masayoshi Takeuchi, Jun-ichi Takino and Sho-ichi Yamagishi

The Macrophage Stimulating Protein/Ron Pathway as a Potential Therapeutic Target to Impede Multiple Mechanisms Involved in Breast Cancer Progression open Access plus

Volume: 11   Issue: 9
Pp: 1157-1168
Kelsi L. Kretschmann, Henok Eyob, Saundra S. Buys and Alana L. Welm

MicroRNA-21: From Cancer to Cardiovascular Disease open Access plus

Volume: 11   Issue: 8
Pp: 926-935
Virginija Jazbutyte and Thomas Thum

Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1 open Access plus

Volume: 10   Issue: 12
Pp: 1212-1226
Akanksha Gupta, Mark D. Williams, William L. Macias, Bruce A. Molitoris and Brian W. Grinnell

Inflammatory Systemic Biomarkers in Setting Acute Coronary Syndromes - Effects of the Diurnal Variation open Access plus

Volume: 10   Issue: 10
Pp: 1001-1008
A. Dominguez-Rodriguez, P. Abreu-Gonzalez and J. C. Kaski

Atherosclerosis and Arterial Blood Pressure in Mice open Access plus

Volume: 8   Issue: 11
Pp: 1181-1189
Hong Lu, Lisa A. Cassis and Alan Daugherty

GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization open Access plus

Volume: 7   Issue: 11
Pp: 1411-1419
Leung Kim and Alan R. Kimmel