Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Cited Article

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Volume:19   Issue:1
Pp: 38-54
Palrasu Manikandan and Siddavaram Nagini*
DOI: 10.2174/1389450118666170125144557

PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials

Volume:19   Issue:1
Pp: 21-37
Dalia Kamel*, Christopher Gray, Jagdeep Singh Walia and Vikaash Kumar*
DOI: 10.2174/1389450118666170711151518

Nanoparticles in Cancer Treatment: Opportunities and Obstacles

Volume:19   Issue:14
Pp: 1696-1709
Rajendra Awasthi*, Ariane Roseblade, Philip Michael Hansbro, Michael John Rathbone, Kamal Dua and Mary Bebawy*
DOI: 10.2174/1389450119666180326122831

Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective

Volume:20   Issue:5
Pp: 501-521
Surovi Saikia and Manobjyoti Bordoloi*
DOI: 10.2174/1389450119666181022153016

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

Volume:19   Issue:8
Pp: 945-959
Mark Schuiveling, Nadia Vazirpanah, Timothy R.D.J. Radstake, Maili Zimmermann* and Jasper C.A. Broen*
DOI: 10.2174/1389450118666170613081730

Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer

Volume:19   Issue:13
Pp: 1478-1490
Jasleen Saini and Pushpender Kumar Sharma*
DOI: 10.2174/1389450118666170823121248

Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review

Volume:20   Issue:7
Pp: 716-726
Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *
DOI: 10.2174/1389450120666181204165344

Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity

Volume:19   Issue:5
Pp: 551-575
Neelesh Maheshwari, Chandrabose Karthikeyan, Piyush Trivedi and N.S. Hari Narayana Moorthy*
DOI: 10.2174/1389450118666170222143739

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Volume:19   Issue:2
Pp: 111-127
Trevor L. Kane, Katelyn E. Carothers and Shaun W. Lee*
DOI: 10.2174/1389450117666161128123536

Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds – Implications for Health

Volume:19   Issue:14
Pp: 1612-1638
Sylwia Borowska*, Malgorzata Michalina Brzoska* and Michal Tomczyk
DOI: 10.2174/1389450119666180403101555

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

Volume:19   Issue:14
Pp: 1710-1720
Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh and Mohamad Fairuz Yahaya*
DOI: 10.2174/1389450119666180326125252

Antitumor Activity of Polysaccharides: An Overview

Volume:19   Issue:1
Pp: 89-96
Ling Chen and Gangliang Huang*
DOI: 10.2174/1389450118666170704143018

Stimuli-responsive Smart Liposomes in Cancer Targeting

Volume:19   Issue:3
Pp: 259-270
Ankit Jain and Sanjay K. Jain*
DOI: 10.2174/1389450117666160208144143

Pathological Roles of Iron in Cardiovascular Disease

Volume:19   Issue:9
Pp: 1068-1076
Motoi Kobayashi, Tomohiro Suhara, Yuichi Baba, Nicholas K. Kawasaki, Jason K. Higa and Takashi Matsui*
DOI: 10.2174/1389450119666180605112235

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD open access plus

Volume:19   Issue:16
Pp: 1882-1896
Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*
DOI: 10.2174/1389450119666180212120012

Nanocarrier Based Advances in Drug Delivery to Tumor: An Overview

Volume:19   Issue:13
Pp: 1498-1518
Ankit Jain, Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava and Sanjay K. Jain*
DOI: 10.2174/1389450119666180131105822

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

Volume:19   Issue:6
Pp: 651-662
Yuanyuan Cheng and Jianhui Rong*
DOI: 10.2174/1389450118666171031115025

Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art

Volume:19   Issue:5
Pp: 527-550
Zahid Hussain*, Hnin Ei Thu, Ahmad Nazrun Shuid, Haliza Katas and Fahad Hussain
DOI: 10.2174/1389450118666170704132523

Celecoxib in Cancer Therapy and Prevention – Review

Volume:20   Issue:3
Pp: 302-315
Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*
DOI: 10.2174/1389450119666180803121737

GRP78 Influences Chemoresistance and Prognosis in Cancer

Volume:19   Issue:6
Pp: 701-708
Jenifer B. Gifford and Reginald Hill*
DOI: 10.2174/1389450118666170615100918

Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy

Volume:19   Issue:2
Pp: 170-180
Afshin Babazadeh, Mahdi Zeinali and Hamed Hamishehkar*
DOI: 10.2174/1389450118666170508095250

Insights into the Targeting Potential of Thymoquinone for Therapeutic Intervention Against Triple-negative Breast Cancer

Volume:19   Issue:1
Pp: 70-80
Md Abul Barkat, Harshita, Javed Ahmad, Mohammad Ahmed Khan*, Sarwar Beg* and Farhan Jalees Ahmad*
DOI: 10.2174/1389450118666170612095959