Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Cited Article

Bioinformatics Approaches for Anti-cancer Drug Discovery promotion: free to download

Volume:21   Issue:1
Pp: 3-17
Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*
DOI: 10.2174/1389450120666190923162203

Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014 promotion: free to download

Volume:21   Issue:3
Pp: 302-317
Yan Xiao and Yajun Liu*
DOI: 10.2174/1389450120666190829162544

ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors promotion: free to download

Volume:21   Issue:9
Pp: 892-901
Ana Luiza Ataide Carneiro de Paula Gonzaga , Vitória Andrade Palmeira , Thomas Felipe Silva Ribeiro , Larissa Braga Costa , Karla Emília de Sá Rodrigues and Ana Cristina Simões-e-Silva *
DOI: 10.2174/1389450121666200210124217

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer promotion: free to download

Volume:21   Issue:3
Pp: 258-278
Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*
DOI: 10.2174/1389450120666190821160730

The Therapeutic Potential of Chemokines in the Treatment of Chemotherapy- Induced Peripheral Neuropathy promotion: free to download

Volume:21   Issue:3
Pp: 288-301
Lin Zhou, Luyao Ao, Yunyi Yan, Wanting Li, Anqi Ye, Yahui Hu*, Weirong Fang* and Yunman Li*
DOI: 10.2174/1389450120666190906153652

TNF-α and IL-6: The Link between Immune and Bone System promotion: free to download

Volume:21   Issue:3
Pp: 213-227
Tiantian Wang and Chengqi He*
DOI: 10.2174/1389450120666190821161259

Antiviral Drug Targets of Single-Stranded RNA Viruses Causing Chronic Human Diseases promotion: free to download

Volume:21   Issue:2
Pp: 105-124
Dhurvas Chandrasekaran Dinesh*, Selvaraj Tamilarasan, Kaushik Rajaram and Evžen Bouřa*
DOI: 10.2174/1389450119666190920153247

IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

Volume:21   Issue:9
Pp: 855-863
Junhui Bai, Yukun Li, Meixiang Li, Sijie Tan* and Daichao Wu*
DOI: 10.2174/1389450121666200429114926

BRCA Mutational Status is a Promising Predictive Biomarker for Platinum- based Chemotherapy in Triple-Negative Breast Cancer

Volume:21   Issue:10
Pp: 962-973
Amal Tazzite*, Hassan Jouhadi, Abdellatif Benider and Sellama Nadifi
DOI: 10.2174/1389450121666200203162541

Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies

Volume:21   Issue:9
Pp: 864-891
Devendra Kumar, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga and Bhupinder Kumar*
DOI: 10.2174/1389450121666200310115327

N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases

Volume:21   Issue:11
Pp: 1056-1067
Hui Zhong, Hui-Fang Tang and Yin Kai*
DOI: 10.2174/1389450121666200210125247

The Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas

Volume:21   Issue:10
Pp: 946-961
Csongor György Lengyel*, Sara Cecilia Altuna, Baker Shalal Habeeb, Dario Trapani and Shah Zeb Khan
DOI: 10.2174/1389450120666191120123612

Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs

Volume:21   Issue:6
Pp: 528-540
Sunil Kumar Dubey*, Shubham Salunkhe, Mukta Agrawal, Maithili Kali, Gautam Singhvi, Sanjay Tiwari, Swarnlata Saraf, Shailendra Saraf and Amit Alexander*
DOI: 10.2174/1389450120666191031092259

Nanosized Modification Strategies for Improving the Antitumor Efficacy of MEK Inhibitors

Volume:21   Issue:3
Pp: 228-251
Yanan Li, Qingrong Dong, Ting Mei, Meichen Zheng, Ramasamy Raj Kumar, Bin Yu, Chunsheng Wu, Hui Zhang* and Feifei An*
DOI: 10.2174/1389450120666190807143245

Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance

Volume:21   Issue:2
Pp: 167-178
Ling Wang, Qi Wang, Yangchun Xu, Manhua Cui and Liying Han*
DOI: 10.2174/1389450120666190925123507

Computational Advances in Chronic Diseases Diagnostics and Therapy - I promotion: free to download

Volume:21   Issue:1
Pp: 1-2
Gurudeeban Selvaraj, Chandrabose Selvaraj and Dong-Qing Wei
DOI: 10.2174/138945012101191206142040

PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives

Volume:22   Issue:2
Pp: 162-170
Thomas Gevaert*, Alessia Cimadamore, Rodolfo Montironi and Markus Eckstein
DOI: 10.2174/1389450121666200510015216

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease

Volume:21   Issue:13
Pp: 1371-1384
Vivek K. Sharma, Thakur G. Singh* and Shareen Singh
DOI: 10.2174/1389450121666200727104728

Combining Growth Factor and Stem Cell Therapy for Stroke Rehabilitation, A Review

Volume:21   Issue:8
Pp: 781-791
Samira Asgharzade, Andisheh Talaei, Tahereh Farkhondeh and Fatemeh Forouzanfar*
DOI: 10.2174/1389450121666200107100747

Navigating Alzheimer’s Disease via Chronic Stress: The Role of Glucocorticoids

Volume:21   Issue:5
Pp: 433-444
Vivek Kumar Sharma and Thakur Gurjeet Singh*
DOI: 10.2174/1389450120666191017114735

Current Study of the Detection and Treatment Targets of Spinal Tuberculosis

Volume:21   Issue:4
Pp: 320-327
Biao Wang*, Wenjie Gao and Dingjun Hao*
DOI: 10.2174/1389450120666191002151637