Current Drug Targets


Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Most Cited Article

Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014 promotion: free to download

Volume:21   Issue:3
Pp: 302-317
Yan Xiao and Yajun Liu*
DOI: 10.2174/1389450120666190829162544

Bioinformatics Approaches for Anti-cancer Drug Discovery promotion: free to download

Volume:21   Issue:1
Pp: 3-17
Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*
DOI: 10.2174/1389450120666190923162203

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer promotion: free to download

Volume:21   Issue:3
Pp: 258-278
Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*
DOI: 10.2174/1389450120666190821160730

The Therapeutic Potential of Chemokines in the Treatment of Chemotherapy- Induced Peripheral Neuropathy promotion: free to download

Volume:21   Issue:3
Pp: 288-301
Lin Zhou, Luyao Ao, Yunyi Yan, Wanting Li, Anqi Ye, Yahui Hu*, Weirong Fang* and Yunman Li*
DOI: 10.2174/1389450120666190906153652

TNF-α and IL-6: The Link between Immune and Bone System

Volume:21   Issue:3
Pp: 213-227
Tiantian Wang and Chengqi He*
DOI: 10.2174/1389450120666190821161259

Antiviral Drug Targets of Single-Stranded RNA Viruses Causing Chronic Human Diseases

Volume:21   Issue:2
Pp: 105-124
Dhurvas Chandrasekaran Dinesh*, Selvaraj Tamilarasan, Kaushik Rajaram and Evžen Bouřa*
DOI: 10.2174/1389450119666190920153247

N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases

Volume:21   Issue:11
Pp: 1056-1067
Hui Zhong, Hui-Fang Tang and Yin Kai*
DOI: 10.2174/1389450121666200210125247

The Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas

Volume:21   Issue:10
Pp: 946-961
Csongor György Lengyel*, Sara Cecilia Altuna, Baker Shalal Habeeb, Dario Trapani and Shah Zeb Khan
DOI: 10.2174/1389450120666191120123612

IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

Volume:21   Issue:9
Pp: 855-863
Junhui Bai, Yukun Li, Meixiang Li, Sijie Tan* and Daichao Wu*
DOI: 10.2174/1389450121666200429114926

ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors promotion: free to download

Volume:21   Issue:9
Pp: 892-901
Ana Luiza Ataide Carneiro de Paula Gonzaga , Vitória Andrade Palmeira , Thomas Felipe Silva Ribeiro , Larissa Braga Costa , Karla Emília de Sá Rodrigues and Ana Cristina Simões-e-Silva *
DOI: 10.2174/1389450121666200210124217

Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies

Volume:21   Issue:9
Pp: 864-891
Devendra Kumar, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga and Bhupinder Kumar*
DOI: 10.2174/1389450121666200310115327

Nanosized Modification Strategies for Improving the Antitumor Efficacy of MEK Inhibitors

Volume:21   Issue:3
Pp: 228-251
Yanan Li, Qingrong Dong, Ting Mei, Meichen Zheng, Ramasamy Raj Kumar, Bin Yu, Chunsheng Wu, Hui Zhang* and Feifei An*
DOI: 10.2174/1389450120666190807143245

Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance

Volume:21   Issue:2
Pp: 167-178
Ling Wang, Qi Wang, Yangchun Xu, Manhua Cui and Liying Han*
DOI: 10.2174/1389450120666190925123507

Computational Advances in Chronic Diseases Diagnostics and Therapy - I promotion: free to download

Volume:21   Issue:1
Pp: 1-2
Gurudeeban Selvaraj, Chandrabose Selvaraj and Dong-Qing Wei
DOI: 10.2174/138945012101191206142040

BRCA Mutational Status is a Promising Predictive Biomarker for Platinum- based Chemotherapy in Triple-Negative Breast Cancer

Volume:21   Issue:10
Pp: 962-973
Amal Tazzite*, Hassan Jouhadi, Abdellatif Benider and Sellama Nadifi
DOI: 10.2174/1389450121666200203162541

Combining Growth Factor and Stem Cell Therapy for Stroke Rehabilitation, A Review

Volume:21   Issue:8
Pp: 781-791
Samira Asgharzade, Andisheh Talaei, Tahereh Farkhondeh and Fatemeh Forouzanfar*
DOI: 10.2174/1389450121666200107100747

Angiotensin Type 1 Receptor Blockers in Heart Failure

Volume:21   Issue:2
Pp: 125-131
Khuraijam Dhanachandra Singh* and Sadashiva S. Karnik*
DOI: 10.2174/1389450120666190821152000

PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay

Volume:21   Issue:16
Pp: 1664-1671
Alessia Cimadamore*, Francesco Massari , Matteo Santoni, Antonio Lopez-Beltran , Liang Cheng , Marina Scarpelli, Rodolfo Montironi and Holger Moch
DOI: 10.2174/1389450121666200324151056

Fluoroquinolones: Blessings Or Curses

Volume:21   Issue:13
Pp: 1354-1370
Priyanka P. Majalekar* and Pramodkumar J. Shirote
DOI: 10.2174/1389450121666200621193355

Immunotherapy and Radiation Therapy in Renal Cell Carcinoma

Volume:21   Issue:14
Pp: 1463-1475
Veronica Mollica, Matteo Santoni, Vincenzo Di Nunno, Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Rodolfo Montironi and Francesco Massari*
DOI: 10.2174/1389450121666200311121540

Use of Anti-VEGF Drugs in Retinal Vein Occlusions

Volume:21   Issue:12
Pp: 1181-1193
Manuel AP Vilela*
DOI: 10.2174/1389450121666200428101343