Abstract
Unlike the more commonly used diuretics, aquaretic agents can induce an increase in urinary volume without incurring a loss of electrolytes. These molecules belong to a family of vasopressin receptor antagonists, V2 in particular, that regulate optional renal water re-absorption via the synthesis and expression of aquaporin-2. In view of their properties, they have become the agent of choice in the treatment of hyponatremic states with water retention, and different studies have demonstrated that they are more effective and practical to use than other traditional approaches in the treatment of diseases such as cirrhosis-related ascites, SIADH and, above all, heart failure. However, the future probably holds the promise of new and unexpected applications for this type of drug in the treatment of several conditions, including polycystic kidney and glomerular disease, glaucoma and Menieres syndrome.
Keywords: Aquaretic, hyponatremia, heart failure, vasopressin, V2 antagonists
Current Pharmaceutical Design
Title: Aquaretic Agents: Whats Beyond the Treatment of Hyponatremia?
Volume: 13 Issue: 8
Author(s): Davide Bolignano, Giuseppe Coppolino, Manila Criseo, Susanna Campo, Adolfo Romeo and Michele Buemi
Affiliation:
Keywords: Aquaretic, hyponatremia, heart failure, vasopressin, V2 antagonists
Abstract: Unlike the more commonly used diuretics, aquaretic agents can induce an increase in urinary volume without incurring a loss of electrolytes. These molecules belong to a family of vasopressin receptor antagonists, V2 in particular, that regulate optional renal water re-absorption via the synthesis and expression of aquaporin-2. In view of their properties, they have become the agent of choice in the treatment of hyponatremic states with water retention, and different studies have demonstrated that they are more effective and practical to use than other traditional approaches in the treatment of diseases such as cirrhosis-related ascites, SIADH and, above all, heart failure. However, the future probably holds the promise of new and unexpected applications for this type of drug in the treatment of several conditions, including polycystic kidney and glomerular disease, glaucoma and Menieres syndrome.
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Bolignano Davide, Coppolino Giuseppe, Criseo Manila, Campo Susanna, Romeo Adolfo and Buemi Michele, Aquaretic Agents: Whats Beyond the Treatment of Hyponatremia?, Current Pharmaceutical Design 2007; 13 (8) . https://dx.doi.org/10.2174/138161207780363040
DOI https://dx.doi.org/10.2174/138161207780363040 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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