Abstract
The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.
Keywords: sepsis, Toll-like receptor, macrophage, protease activated receptor, endothelial phenotype, VCAM
Current Drug Targets
Title: Endothelium as a Therapeutic Target in Sepsis
Volume: 8 Issue: 4
Author(s): William C. Aird
Affiliation:
Keywords: sepsis, Toll-like receptor, macrophage, protease activated receptor, endothelial phenotype, VCAM
Abstract: The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.
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Cite this article as:
Aird C. William, Endothelium as a Therapeutic Target in Sepsis, Current Drug Targets 2007; 8 (4) . https://dx.doi.org/10.2174/138945007780362782
DOI https://dx.doi.org/10.2174/138945007780362782 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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