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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Homologation of Estrone or Estradiol. Appending a Carbon Substituent Into the 3-hydroxyestra-1,3,5-triene Skeleton

Author(s): S. Braune, S. Deb, T. Hase and K. Wahala

Volume 11, Issue 4, 2007

Page: [383 - 405] Pages: 23

DOI: 10.2174/138527207780059349

Price: $65

Abstract

Recent work is reviewed concerning the synthesis of estrone or estradiol homologues, of interest in diagnostics, drug discovery research etc. The survey is limited to reactions where a carbon atom or a carbon chain becomes directly attached to the steroid ring system. Also conversions of non-estranoid starting materials to substituted estrone/estradiol derivatives are discussed. The organization of the review follows steroid numbering.

Keywords: hydroxymethylated derivative, estrogen derivatives, Barton-McCombie deoxygenation, C-alkylation, Wolff-Kishner reduction

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