ISSN (Print): 1573-3998
ISSN (Online): 1875-6417
Volume 17, 9 Issues, 2021
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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417
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Special Issue Submission
Growing Burden of Diabetes in Sub- Saharan Africa: Contribution of Pesticides ?, 2013 : 9(6); 437 - 449
Colette Sylvie Azandjeme , Michèle Bouchard,, Benjamin Fayomi, Francois Djrolo Dismand Houinato and Hélène Delisle.
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"Current Diabetes Reviews fills a unique niche in the medical literature by publishing timely, high-quality reviews of clinically-relevant topics that have tremendous and immediate utility for the practicing clinician and the academician alike."
David G. Armstrong
Rosalind Franklin Univ., USA
Thank you very much for the work you have done to publish my manuscript. I had an enjoyable publishing experience with you! We are very grateful for your help with the publication process and your friendly and prompt responses to our queries. I really appreciate the detailed comments from the cooperative editors/reviewers and the fast processing of my manuscript.
Diabetes mellitus is a complicated endocrine metabolic disorder which is caused due to insufficient or inefficient insulin
content in our body and it is mainly characterized by hyperglycemia. This metabolic disorder not only affects the carbohydrate
metabolic processes but also affects the protein and lipid metabolic processes. The major abnormality in the case of diabetes is
not caused due to a higher amount of glucose, but the secondary metabolites which are produced from high amount of glucose
or glucose metabolism led to secondary complications of diabetes mellitus . These secondary complications can affect almost
all the body organs including the nervous system, heart, eyes, kidney, lower limbs, macro, micro blood capillaries, etc. In
fact, these complications have an important impact on the quality of life and life expectancy. Therefore, one of the main goals
of diabetes treatment is preventing or delay in the appearance and progression of different complications. However, in recent
years, it is evident that diabetes leads not only to vascular complications but also with other complications like non-alcoholic
fatty liver disease, cardiomyopathy, dementia, and an increased incidence of different types of cancer .
In current thematic issue entitled as “Pathophysiology of diabetic secondary complication and their management”, we have
enclosed valued articles discussing the inventions and exploration carried out on the management of diabetes and its complications.
Six exhaustive reviews were included from the experts in the diverse field of drug design, pharmacology and formulation
for the pharmacological interventions in the management of secondary complications of diabetes.
Awasthi and colleagues  have focussed on one of the major secondary complications of diabetes, that is diabetic foot ulcer.
After a very rigorous literature review and analysis, they explained all the available treatment strategies and also the possible
way to manage diabetic foot ulcer.
Medicinal plants are known for various bioactive antidiabetic constituents. Generally herbal medicines are safer and they
work synergistically a well. Shubham Kumar and his group  have very elaborately discussed the herbal medicines and their
role in the management of diabetes mellitus.
The major issue in the case of diabetes mellitus is the secondary complications. The glucose is the central biomolecule in
the biochemical pathways which takes place in our body. Babel and Dandekar  have described in detail all the possible
mechanisms which lead to secondary complications. The complication mechanism have been supported with self-explanatory
Marco and co-workers  have exhaustibly worked and covered all the parts of peripheral arterial disease in the case of diabetics.
They have conducted a complete overview and state of the art in the treatment of patients with diabetes, peripheral arterial
disease, and foot ulceration and to describe the current challenges and future perspectives.
Grover and their colleagues  submitted their article which deals with the pathophysiology of diabetes along with its
comorbidities, with a focus on existing and novel upcoming antidiabetic drugs which are under investigation.
The last review of this special issue is sybmitted by Manimaran and his group . They have shown a nanoemulsion based
approach for the antidiabetic drug delivery. There are many drawbacks associated with conventional delivery system like poor
absorption and low bioavailability. Nanoemulsion overcomes these drawbacks of conventional delivery system.
I had a great experience and feel pleasure to work with the Director Kazim Baig and his team especially Editorial Assistant
Manager Tabinda Hassan. I express our sincere gratitude for them for allowing me to work as the Guest Editors in the journal
Current Diabetes Reviews. I hope and wish that this thematic issue will be fruitful for the enormous readership and may assist
the researcher as a good information source in the field of diabetes, and its management.
In the last decades, the spectrum of autoimmune diabetes in adults has been enlarged by the discovery and characterization
of so-called latent autoimmune diabetes in adults (LADA). The definition of LADA stems from the observation that a large
minority of individuals who had been diagnosed as having non-insulin dependent diabetes possessed antibodies, such as ICA
and GADA, that were also found in in “classical” type 1 diabetes. It has become evident that the phenotype and the progression
of dysmetabolism in LADA patients differs in several respects from that of both antibody-negative individuals with type 2 diabetes
and of childhood or adolescence onset type 1 diabetes. Many studies on LADA have described phenotypes with characteristics
in-between those of type 1 and type 2 diabetes. These observations have given rise to the nickname “diabetes 1.5” for
However, the etiology, phenotype and optimal treatment of LADA have only partly been elucidated and have been the subject
of sometimes intense debate. Yet, our understanding of this form of diabetes is steadily increasing. The aim of a symposium
held April 21st 2017 in Trondheim, Norway, was to provide an update on selected features of LADA and also to discuss
what should be desirable and feasible in terms of future research on LADA. The papers on LADA that are presented in his thematic
issue are based on the presentations and discussions during the symposium and have been supplemented by findings that
are even more recent.
I hope that these review articles on LADA will be of interest and relevance to researchers on LADA as well as to diabetologists
who are treating LADA patients.
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