Abstract
The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM- 1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation. These molecules are responsible for recruiting leukocytes onto the vascular endothelium before extravasation to the injured tissues. Some circulating cancer cells have been shown to extravasate to a secondary site using a process similar to inflammatory cells. The most studied ligands for CAMs expressed on cancer cells, sialyl Lewis (a/x) antigens, are shown to be involved in adhesion to endothelial cells by binding to E-selectin. This process, shared by inflammatory cells and cancer cells, may partially explain the link between inflammation and tumorigenesis. Furthermore, this process may elucidate the therapeutic benefit of anti-inflammatory drugs in cancer treatment. The complexity of the tumor microenvironment has been revealed in the past decade. Currently, intense investigation is aimed at various aspects of the tumor microenvironment in addition to the tumor cells themselves. Here, we review the role of CAMs in extravasation of circulating cancer cells, a key step in metastasis.
Keywords: E-selectin expression, Macrosphelide B, colon cancer, ICAM-1, Inflammatory Cytokines, VCAM-1
Current Medicinal Chemistry
Title: Endothelial Cell Adhesion Molecules and Cancer Progression
Volume: 14 Issue: 4
Author(s): Hanako Kobayashi, Kimberly C. Boelte and P. Charles Lin
Affiliation:
Keywords: E-selectin expression, Macrosphelide B, colon cancer, ICAM-1, Inflammatory Cytokines, VCAM-1
Abstract: The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM- 1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation. These molecules are responsible for recruiting leukocytes onto the vascular endothelium before extravasation to the injured tissues. Some circulating cancer cells have been shown to extravasate to a secondary site using a process similar to inflammatory cells. The most studied ligands for CAMs expressed on cancer cells, sialyl Lewis (a/x) antigens, are shown to be involved in adhesion to endothelial cells by binding to E-selectin. This process, shared by inflammatory cells and cancer cells, may partially explain the link between inflammation and tumorigenesis. Furthermore, this process may elucidate the therapeutic benefit of anti-inflammatory drugs in cancer treatment. The complexity of the tumor microenvironment has been revealed in the past decade. Currently, intense investigation is aimed at various aspects of the tumor microenvironment in addition to the tumor cells themselves. Here, we review the role of CAMs in extravasation of circulating cancer cells, a key step in metastasis.
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Cite this article as:
Kobayashi Hanako, Boelte C. Kimberly and Lin P. Charles, Endothelial Cell Adhesion Molecules and Cancer Progression, Current Medicinal Chemistry 2007; 14 (4) . https://dx.doi.org/10.2174/092986707779941032
DOI https://dx.doi.org/10.2174/092986707779941032 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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