Abstract
Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents are considered to be among the most dangerous chemical warfare agents. The oximes represent very important part of antidotal medical countermeasures. They are used to reactivate the nerve agent-inhibited acetylcholinesterase. Despite long-term research activities, there is no single, broad-spectrum oxime suitable for the antidotal treatment of poisoning with all organophosphorus agents. Therefore, the development of new structural analogues of currently available oximes should continue to increase the effectiveness of antidotal treatment of poisoning by organophosphorus compounds. The review describes the development of new structural analogues of currently available oximes and the evaluation of their potency to counteract the acute toxicity of some nerve agents (tabun, cyclosarin) in comparison with commonly used oximes (pralidoxime, obidoxime, trimedoxime, HI-6).
Keywords: acetylcholinesterase, Artificial Neural Networks, AChE Reactivators, Trimedoxime, Atropine
Current Organic Chemistry
Title: The Development of New Structural Analogues of Oximes for the Antidotal Treatment of Poisoning by Nerve Agents and the Comparison of Their Reactivating and Therapeutic Efficacy with Currently Available Oximes
Volume: 11 Issue: 3
Author(s): Jiri Kassa, Kamil Kuca, Lucie Bartosova and Gabriela Kunesova
Affiliation:
Keywords: acetylcholinesterase, Artificial Neural Networks, AChE Reactivators, Trimedoxime, Atropine
Abstract: Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents are considered to be among the most dangerous chemical warfare agents. The oximes represent very important part of antidotal medical countermeasures. They are used to reactivate the nerve agent-inhibited acetylcholinesterase. Despite long-term research activities, there is no single, broad-spectrum oxime suitable for the antidotal treatment of poisoning with all organophosphorus agents. Therefore, the development of new structural analogues of currently available oximes should continue to increase the effectiveness of antidotal treatment of poisoning by organophosphorus compounds. The review describes the development of new structural analogues of currently available oximes and the evaluation of their potency to counteract the acute toxicity of some nerve agents (tabun, cyclosarin) in comparison with commonly used oximes (pralidoxime, obidoxime, trimedoxime, HI-6).
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Cite this article as:
Kassa Jiri, Kuca Kamil, Bartosova Lucie and Kunesova Gabriela, The Development of New Structural Analogues of Oximes for the Antidotal Treatment of Poisoning by Nerve Agents and the Comparison of Their Reactivating and Therapeutic Efficacy with Currently Available Oximes, Current Organic Chemistry 2007; 11 (3) . https://dx.doi.org/10.2174/138527207779940874
DOI https://dx.doi.org/10.2174/138527207779940874 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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