Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research


Gerald H. Lushington
LiS Consulting, Lawrence

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Open Access Articles

Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Different Schemes in China: A Data Mining Approach open Access plus

Volume: 24   Issue: 7
Pp: 957-967
LiWei Yin, YaCen Gao, ZiPing Li*, MengYu Wang and KaiXin Chen

Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy open Access plus

Volume: 24   Issue: 5
Pp: 701-715
Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*

Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans open Access plus

Volume: 24   Issue: 1
Pp: 109-118
Eti Apriyanti, Mieke H. Satari and Dikdik Kurnia*

Synthesis of Eicosapentaenoic Acid-enriched Phosphatidylcholine and its Effect on Pro-inflammatory Cytokine Expression open Access plus

Volume: 24  
Pp: 1-6
Jae Yeul Baek, Eun Na and Sun Young Lim*

Exploring miRNA-related Molecular Targets of Erchen Decoction Against Lipid Metabolism Disorder using A Network Pharmacologic Approach open Access plus

Volume: 24  
Pp: 1-12
Shanshan Ding, Qiliang Chen, Yiqing Huang, Xiaomei Li, Yujuan Chai, Candong Li and Tetsuya Asakawa*

KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor for Alzheimer’s Disease open Access plus

Volume: 23   Issue: 9
Pp: 836-841
Abdullah Al Mamun and Md. Sahab Uddin*

Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy open Access plus

Volume: 23   Issue: 4
Pp: 334-344
Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*

An Investigation of the Mechanism of Rapid Relief of Ulcerative Colitis Induced by Five-flavor Sophora Flavescens Enteric-coated Capsules Based on Network Pharmacology open Access plus

Volume: 23   Issue: 3
Pp: 239-252
Sizhen Gu, Yan Xue, Yuli Zhang, Kanjun Chen, Shigui Xue, Ji Pan, Yini Tang, Hui Zhu, Huan Wu and Danbo Dou*

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development open Access plus

Volume: 22   Issue: 6
Pp: 379-386
Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*

Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats open Access plus

Volume: 22   Issue: 5
Pp: 326-332
Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*

Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types open Access plus

Volume: 21   Issue: 10
Pp: 771-783
Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*

A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information open Access plus

Volume: 21   Issue: 9
Pp: 670-680
Zi-Han Guo, Lei Chen* and Xian Zhao

Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation open Access plus

Volume: 21   Issue: 2
Pp: 100-110
Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao

High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review open Access plus

Volume: 19   Issue: 8
Pp: 605-615
Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*

An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever open Access plus

Volume: 19   Issue: 7
Pp: 516-536
Chelsea N. Powers and William N. Setzer*

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library open Access plus

Volume: 19   Issue: 4
Pp: 262-274
Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*

Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP open Access plus

Volume: 18   Issue: 1
Pp: 3-17
Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*

Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening open Access plus

Volume: 17   Issue: 1
Pp: 80-88
Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*

Chemical Informatics and the Drug Discovery Knowledge Pyramid open Access plus

Volume: 16   Issue: 10
Pp: 764-776
Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham

A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery open Access plus

Volume: 16   Issue: 3
Pp: 199-209
Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee

A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization open Access plus

Volume: 15   Issue: 9
Pp: 686-704
Bhavneet Bhinder and Hakim Djaballah*

Application of NMR Metabolomics to Search for Human Disease Biomarkers open Access plus

Volume: 15   Issue: 8
Pp: 595-610
Teklab Gebregiworgis and Robert Powers*

Alternative Medicine Safety: Agaricus blazei and Propolis open Access plus

Volume: 14   Issue: 7
Pp: 616-621
Kenji Sorimachi* and Takaaki Nakamoto

The Design and Application of Target-Focused Compound Libraries open Access plus

Volume: 14   Issue: 6
Pp: 521-531
C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten

Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling open Access plus

Volume: 14   Issue: 4
Pp: 248-266
David Sedlak, Aileen Paguio and Petr Bartunek*

Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance open Access plus

Volume: 13   Issue: 2
Pp: 188-206
James M. McKim Jr.*

Generating ‘Omic Knowledge’: The Role of Informatics in High Content Screening open Access plus

Volume: 12   Issue: 9
Pp: 917-925
Mark A. Collins*

Applications of High Content Screening in Life Science Research open Access plus

Volume: 12   Issue: 9
Pp: 870-876
Joseph M. Zock*

Combinatorics of Reaction-Network Posets open Access plus

Volume: 11   Issue: 9
Pp: 723-733
Douglas J. Klein*, Teodora Ivanciuc, Anton Ryzhov and Ovidiu Ivanciuc

Machine Learning for In Silico Virtual Screening and Chemical Genomics: New Strategies open Access plus

Volume: 11   Issue: 8
Pp: 677-685
Jean-Philippe Vert* and Laurent Jacob

Fluorescent Probes for Cellular Assays open Access plus

Volume: 11   Issue: 7
Pp: 505-513
George T. Hanson and Bonnie J. Hanson*

Label-Free Cell-Based Assays for GPCR Screening open Access plus

Volume: 11   Issue: 5
Pp: 357-369
Ye Fang*, Anthony G. Frutos and Ronald Verklereen

Pharmacological Characterization of Ligands at Recombinant NMDA Receptor Subtypes by Electrophysiological Recordings and Intracellular Calcium Measurements open Access plus

Volume: 11   Issue: 4
Pp: 304-315
Kasper B. Hansen*, Hans Brauner-Osborne and Jan Egebjerg

Back to Basics: Label-Free Technologies for Small Molecule Screening open Access plus

Volume: 11   Issue: 3
Pp: 231-237
Andrew K. Shiau*, Mark E. Massari and Can C. Ozbal

Discovery of Novel Targets with High Throughput RNA Interference Screening open Access plus

Volume: 11   Issue: 3
Pp: 175-184
Paul D. Kassner*

High Throughput Screening of Gene Functions in Mammalian Cells Using Reversely Transfected Cell Arrays: Review And Protocol open Access plus

Volume: 11   Issue: 2
Pp: 159-172
Michael Sturzl*, Andreas Konrad, Gaby Sander, Effi Wies, Frank Neipel, Elisabeth Naschberger, Simone Reipschlager, Nathalie Gonin-Laurent, Raymund E. Horch, Ulrich Kneser, Werner Hohenberger, Holger Erfle and Mathias Thurau

Yeast Genomics and Drug Target Identification open Access plus

Volume: 10   Issue: 8
Pp: 618-634
Nike Bharucha and Anuj Kumar*