Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research


Gerald H. Lushington
LiS Consulting, Lawrence

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Preface (Hot Topic: Fluorescence-based Screening Methods Guest Editor: Kyle R. Gee ). promotion: free to download

Volume:6   Issue: 4
Pp: i-i
Kyle R. Gee
DOI: 10.2174/138620703106298428

Phenotypic Screening of Small Molecule Libraries by High Throughput Cell Imaging

Volume:6   Issue: 4
Pp: 279-286
J. C. Yarrow, Y. Feng, Z. E. Perlman, T. Kirchhausen and T. J. Mitchison
DOI: 10.2174/138620703106298527

A Fluorescent High-Throughput Assay for Double-Stranded DNA: the RediPlate PicoGreen Assay

Volume:6   Issue: 4
Pp: 287-291
Robert Batchelor, David Hagen, Iain Johnson and Joseph Beechem
DOI: 10.2174/138620703106298536

Rapid Assays for Quantitating Cytokine Gene Expression Without Target Amplification

Volume:6   Issue: 4
Pp: 293-301
Frank R. Gonzales, Augusto Lois, Toddy Sewell, Carl LaCerte, Barbara Gaynor, Edison Garcia, Melinda Jazdzewski, Tammy Oliver, Irene Postor and Deirdre Trainor
DOI: 10.2174/138620703106298545

Assay Development and High-Throughput Screening of Caspases in Microfluidic Format

Volume:6   Issue: 4
Pp: 303-312
Ge Wu, Jennifer Irvine, Chris Luft, David Pressley, C. Nicholas Hodge and Bill Janzen
DOI: 10.2174/138620703106298554

Fluorescence Assays for High-Throughput Screening of Protein Kinases

Volume:6   Issue: 4
Pp: 313-320
G. J.R. Zaman, A. Garritsen, Th. de Boer and C. A.A. van Boeckel
DOI: 10.2174/138620703106298563

Competitive Fluorescence Polarization Assays for the Detection of Phosphoinositide Kinase and Phosphatase Activity

Volume:6   Issue: 4
Pp: 321-330
Beth E. Drees, Amber Weipert, Heather Hudson, Colin G. Ferguson, Leena Chakravarty and Glenn D. Prestwich
DOI: 10.2174/138620703106298572

Strategies and Solid-Phase Formats for the Analysis of Protein and Peptide Phosphorylation Employing A Novel Fluorescent Phosphorylation Sensor Dye

Volume:6   Issue: 4
Pp: 331-339
Karen Martin, Thomas H. Steinberg, Terrie Goodman, Birte Schulenberg, Jason A. Kilgore, Kyle R. Gee, Joseph M. Beechem and Wayne F. Patton
DOI: 10.2174/138620703106298581

Development of Fluorescence-Based Selective Assays for Serine / Threonine and Tyrosine Phosphatases

Volume:6   Issue: 4
Pp: 341-346
Christina Pastula, Iain Johnson, Joseph M. Beechem and Wayne F. Patton
DOI: 10.2174/138620703106298590

Homogeneous Fluorescence Assay for Cyclic AMP

Volume:6   Issue: 4
Pp: 347-354
Ewa Heyduk, Ying Fei and Tomasz Heyduk
DOI: 10.2174/138620703106298437

Measuring Intracellular Calcium Fluxes in High Throughput Mode

Volume:6   Issue: 4
Pp: 355-362
Chris Chambers, Fiona Smith, Christine Williams, Sandra Marcos, Zhen Han Liu, Paul Hayter, Giuseppe Ciaramella, Wilma Keighley, Phil Gribbon and Andreas Sewing
DOI: 10.2174/138620703106298446

New Ca2+ Fluoroionophores Based on the BODIPY Fluorophore

Volume:6   Issue: 4
Pp: 363-366
Kyle R. Gee, Aleksey Rukavishnikov and Anca Rothe
DOI: 10.2174/138620703106298455

High Throughput Screening of G-Protein Coupled Receptors via Flow Cytometry

Volume:6   Issue: 4
Pp: 389-397
A. Waller, P. Simons, E. R. Prossnitz, B. S. Edwards and L. A. Sklar
DOI: 10.2174/138620703106298482

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Heterotrimeric G-Protein Alpha Subunits and Regulator of G-Protein Signaling (RGS) Proteins

Volume:6   Issue: 4
Pp: 399-407
Randall J. Kimple, Miller B. Jones, Adam Shutes, Benjamin R. Yerxa, David P. Siderovski and Francis S. Willard
DOI: 10.2174/138620703106298491

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Ras-Superfamily GTPases

Volume:6   Issue: 4
Pp: 409-418
Rafael J. Rojas, Randall J. Kimple, Kent L. Rossman, David P. Siderovski and John Sondek
DOI: 10.2174/138620703106298509

Meet the Guest Editor promotion: free to download

Volume:6   Issue: 4
Pp: 419-419
Kyle R. Gee
DOI: 10.2174/138620703106298518