Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research


Gerald H. Lushington
LiS Consulting
Lawrence, KS

Personal Subscription
Become EABM
Become Reviewer
Call for Editor
Volume: 6 Issue: 4, June

Preface (Hot Topic: Fluorescence-based Screening Methods Guest Editor: Kyle R. Gee ).

Volume:6   Issue: 4
Pp: i-i
Kyle R. Gee
DOI: 10.2174/138620703106298428

Phenotypic Screening of Small Molecule Libraries by High Throughput Cell Imaging

Volume:6   Issue: 4
Pp: 279-286
J. C. Yarrow, Y. Feng, Z. E. Perlman, T. Kirchhausen and T. J. Mitchison
DOI: 10.2174/138620703106298527

A Fluorescent High-Throughput Assay for Double-Stranded DNA: the RediPlate PicoGreen Assay

Volume:6   Issue: 4
Pp: 287-291
Robert Batchelor, David Hagen, Iain Johnson and Joseph Beechem
DOI: 10.2174/138620703106298536

Rapid Assays for Quantitating Cytokine Gene Expression Without Target Amplification

Volume:6   Issue: 4
Pp: 293-301
Frank R. Gonzales, Augusto Lois, Toddy Sewell, Carl LaCerte, Barbara Gaynor, Edison Garcia, Melinda Jazdzewski, Tammy Oliver, Irene Postor and Deirdre Trainor
DOI: 10.2174/138620703106298545

Assay Development and High-Throughput Screening of Caspases in Microfluidic Format

Volume:6   Issue: 4
Pp: 303-312
Ge Wu, Jennifer Irvine, Chris Luft, David Pressley, C. Nicholas Hodge and Bill Janzen
DOI: 10.2174/138620703106298554

Fluorescence Assays for High-Throughput Screening of Protein Kinases

Volume:6   Issue: 4
Pp: 313-320
G. J.R. Zaman, A. Garritsen, Th. de Boer and C. A.A. van Boeckel
DOI: 10.2174/138620703106298563

Competitive Fluorescence Polarization Assays for the Detection of Phosphoinositide Kinase and Phosphatase Activity

Volume:6   Issue: 4
Pp: 321-330
Beth E. Drees, Amber Weipert, Heather Hudson, Colin G. Ferguson, Leena Chakravarty and Glenn D. Prestwich
DOI: 10.2174/138620703106298572

Strategies and Solid-Phase Formats for the Analysis of Protein and Peptide Phosphorylation Employing A Novel Fluorescent Phosphorylation Sensor Dye

Volume:6   Issue: 4
Pp: 331-339
Karen Martin, Thomas H. Steinberg, Terrie Goodman, Birte Schulenberg, Jason A. Kilgore, Kyle R. Gee, Joseph M. Beechem and Wayne F. Patton
DOI: 10.2174/138620703106298581

Development of Fluorescence-Based Selective Assays for Serine / Threonine and Tyrosine Phosphatases

Volume:6   Issue: 4
Pp: 341-346
Christina Pastula, Iain Johnson, Joseph M. Beechem and Wayne F. Patton
DOI: 10.2174/138620703106298590

Homogeneous Fluorescence Assay for Cyclic AMP

Volume:6   Issue: 4
Pp: 347-354
Ewa Heyduk, Ying Fei and Tomasz Heyduk
DOI: 10.2174/138620703106298437

Measuring Intracellular Calcium Fluxes in High Throughput Mode

Volume:6   Issue: 4
Pp: 355-362
Chris Chambers, Fiona Smith, Christine Williams, Sandra Marcos, Zhen Han Liu, Paul Hayter, Giuseppe Ciaramella, Wilma Keighley, Phil Gribbon and Andreas Sewing
DOI: 10.2174/138620703106298446

New Ca2+ Fluoroionophores Based on the BODIPY Fluorophore

Volume:6   Issue: 4
Pp: 363-366
Kyle R. Gee, Aleksey Rukavishnikov and Anca Rothe
DOI: 10.2174/138620703106298455

High Throughput Screening of G-Protein Coupled Receptors via Flow Cytometry

Volume:6   Issue: 4
Pp: 389-397
A. Waller, P. Simons, E. R. Prossnitz, B. S. Edwards and L. A. Sklar
DOI: 10.2174/138620703106298482

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Heterotrimeric G-Protein Alpha Subunits and Regulator of G-Protein Signaling (RGS) Proteins

Volume:6   Issue: 4
Pp: 399-407
Randall J. Kimple, Miller B. Jones, Adam Shutes, Benjamin R. Yerxa, David P. Siderovski and Francis S. Willard
DOI: 10.2174/138620703106298491

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Ras-Superfamily GTPases

Volume:6   Issue: 4
Pp: 409-418
Rafael J. Rojas, Randall J. Kimple, Kent L. Rossman, David P. Siderovski and John Sondek
DOI: 10.2174/138620703106298509

Meet the Guest Editor

Volume:6   Issue: 4
Pp: 419-419
Kyle R. Gee
DOI: 10.2174/138620703106298518