Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research


Gerald H. Lushington
LiS Consulting, Lawrence

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Insight into the Structural Requirements of Narlaprevir-Type Inhibitors of NS3/NS4A Protease Based on HQSAR and Molecular Field Analyses

Volume:15   Issue: 6
Pp: 439-450
Jingyu Zhu, Youyong Li, Huidong Yu, Liling Zhang, Xinliang Mao and Tingjun Hou
DOI: 10.2174/138620712800563918
Published on: 02 May, 2012

Iodocyclization, Followed by Palladium-Catalyzed Coupling: A Versatile Strategy for Heterocyclic Library Construction

Volume:15   Issue: 6
Pp: 451-472
Anton V. Dubrovskiy, Nataliya A. Markina and Richard C. Larock
DOI: 10.2174/138620712800563927
Published on: 02 May, 2012

Application of Affinity Selection-Mass Spectrometry Assays to Purification and Affinity-Based Screening of the Chemokine Receptor CXCR4

Volume:15   Issue: 6
Pp: 473-485
Charles E. Whitehurst, Zhiping Yao, Denise Murphy, Mingxuan Zhang, Shane Taremi, Lisa Wojcik, Julie M. Strizki, Jack D. Bracken, Cliff C. Cheng, Xianshu Yang, Gerald W. Shipps, Michael Ziebell and Elliott Nickbarg
DOI: 10.2174/138620712800563945
Published on: 02 May, 2012

A Support Vector Machine Based Method to Predict Success for Polymerase Chain Reactions

Volume:15   Issue: 6
Pp: 486-491
Xiaoqing Yu, Xiaoqi Zheng, Liangyu Meng, Chun Li and Jun Wang
DOI: 10.2174/138620712800563936
Published on: 02 May, 2012

Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine

Volume:15   Issue: 6
Pp: 492-502
Kai Wang, Xiaoying Hu, Zhi Wang and Aixia Yan
DOI: 10.2174/138620712800563891
Published on: 02 May, 2012

A Simple and Effective Approach to the Synthesis of Isoquinoline Derivatives Under Solvent-Free Conditions

Volume:15   Issue: 6
Pp: 503-508
Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan and Mohammad A. Khalilzadeh
DOI: 10.2174/138620712800563909
Published on: 02 May, 2012

Enantiomeric Resolution of Ibuprofen and Flurbiprofen in Human Plasma by SPE-Chiral HPLC Methods

Volume:15   Issue: 6
Pp: 509-514
Imran Ali, Iqbal Hussain, Kishwar Saleem and Hassan Y. Aboul-Enein
DOI: 10.2174/138620712800563882
Published on: 02 May, 2012