Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)

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Volume: 12 Issue: 1, January

Editorial [Hot Topic: Ion Channels: Applications in Ion Channel Drug Discovery(Guest Editor: Douglas S. Krafte)]

Volume:12   Issue: 1
Pp: 1-1
Douglas S. Krafte
DOI: 10.2174/138620709787048046
Published on: 01 March, 2012

Evolution of the Human Ion Channel Set

Volume:12   Issue: 1
Pp: 2-23
Surendra K. Nayak, Serge Batalov, Timothy J. Jegla and Christian M. Zmasek
DOI: 10.2174/138620709787047957
Published on: 01 March, 2012

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

Volume:12   Issue: 1
Pp: 24-37
Niels Fertig, Andrea Bruggemann, Mohamed Kreir, Michael George, Sonja Stoelzle, Claudia Haarmann, Cecilia Farre and Alison Haythornthwaite
DOI: 10.2174/138620709787047966
Published on: 01 March, 2012

High Throughput Electrophysiology with Xenopus Oocytes

Volume:12   Issue: 1
Pp: 38-50
Cathy Smith-Maxwell and Roger L. Papke
DOI: 10.2174/138620709787047975
Published on: 01 March, 2012

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

Volume:12   Issue: 1
Pp: 51-63
Mads P.G. Korsgaard, Dorte Strobaek and Palle Christophersen
DOI: 10.2174/138620709787048037
Published on: 01 March, 2012

HCN Channels as Targets for Drug Discovery

Volume:12   Issue: 1
Pp: 64-72
Alan D. Wickenden, Sandra R. Chaplan, Adrienne E. Dubin, Hong-Qing Guo, Nyan-Tsz Wu and Michael P. Maher
DOI: 10.2174/138620709787048028
Published on: 01 March, 2012

The Chiptip: A Novel Tool for Automated Patch Clamp

Volume:12   Issue: 1
Pp: 73-77
Andjelko Golubovic, Martina Knirsch, Uwe Czubayko, Alexander Hummer, Albrecht Lepple-Wienhues and Dirck Lassen
DOI: 10.2174/138620709787047984
Published on: 01 March, 2012

QPatch: The Missing Link Between HTS and Ion Channel Drug Discovery

Volume:12   Issue: 1
Pp: 78-95
Yi Liu, Chris Mathes, Soren Friis and Michael Finley
DOI: 10.2174/138620709787047948
Published on: 01 March, 2012

Use of Planar Array Electrophysiology for the Development of Robust Ion Channel Cell Lines

Volume:12   Issue: 1
Pp: 96-106
Jeffrey J. Clare, Mao Xiang Chen, David L. Downie, Derek J. Trezise and Andrew J. Powell
DOI: 10.2174/138620709787048000
Published on: 01 March, 2012

Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

Volume:12   Issue: 1
Pp: 107-122
Neil Castle, David Printzenhoff, Shannon Zellmer, Brett Antonio, Alan Wickenden and Christopher Silvia
DOI: 10.2174/138620709787047993
Published on: 01 March, 2012

Meet The Guest Editor

Volume:12   Issue: 1
Pp: 123-123
Douglas S. Krafte
DOI: 10.2174/138620709787048019
Published on: 01 March, 2012