Current Cancer Drug Targets


Ruiwen Zhang
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204

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C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

Volume: 21   Issue: 1
Pp: 2-20
Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*
DOI: 10.2174/1568009620666201016121005

Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

Volume: 20   Issue: 11
Pp: 887-895
Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello
DOI: 10.2174/1568009620999200918122426

Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

Volume: 20   Issue: 10
Pp: 811-817
Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*
DOI: 10.2174/1568009620666200628105727

Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

Volume: 20   Issue: 9
Pp: 710-719
Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*
DOI: 10.2174/1568009620666200504112711

Strategic Combination Therapies for Ovarian Cancer

Volume: 20   Issue: 8
Pp: 573-585
Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*
DOI: 10.2174/1568009620666200511084007

Autophagy Driven Extracellular Vesicles in the Leukaemic Microenvironment

Volume: 20   Issue: 7
Pp: 501-512
Rebecca H. Horton, Tom Wileman and Stuart A. Rushworth*
DOI: 10.2174/1568009620666200428111051

COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide

Volume: 20   Issue: 6
Pp: 410-416
Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*
DOI: 10.2174/1568009620666200414151419

CDK9: Therapeutic Perspective in HCC Therapy

Volume: 20   Issue: 5
Pp: 318-324
Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg
DOI: 10.2174/1568009620666200212124357

PPARγ Agonists in Combination Cancer Therapies

Volume: 20   Issue: 3
Pp: 197-215
Piotr Mrowka and Eliza Glodkowska-Mrowka*
DOI: 10.2174/1568009619666191209102015

Novel Mechanistic Insights into the Anti-cancer Mode of Arsenic Trioxide

Volume: 20   Issue: 2
Pp: 115-129
Md Wahiduzzaman, Akinobu Ota* and Yoshitaka Hosokawa
DOI: 10.2174/1568009619666191021122006

Autophagy and Apoptosis Specific Knowledgebases-guided Systems Pharmacology Drug Research

Volume: 19   Issue: 9
Pp: 716-728
Peihao Fan, Nanyi Wang, Lirong Wang * and Xiang-Qun Xie *
DOI: 10.2174/1568009619666190206122149

Molecular Mechanisms and Targeted Therapies Including Immunotherapy for Non-Small Cell Lung Cancer

Volume: 19   Issue: 8
Pp: 595-630
Tatsuya Nagano*, Motoko Tachihara and Yoshihiro Nishimura
DOI: 10.2174/1568009619666181210114559

Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View

Volume: 19   Issue: 6
Pp: 430-448
Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood and Showkat Ahmad Ganie*
DOI: 10.2174/1568009618666180803104631

Targeting Glycosylation Aberrations to Improve the Efficiency of Cancer Phototherapy

Volume: 19   Issue: 5
Pp: 349-359
Guillaume Poiroux, Annick Barre, Pierre Rougé and Hervé Benoist*
DOI: 10.2174/1568009618666180628101059

The Evaluation of Animal Models in the Development of Anticancer Agents: From Preclinical to Clinical Tests

Volume: 19   Issue: 4
Pp: 277-284
Jie Wang, Haiyan Dong, Jian Liu, Ning Zheng, Xiaodong Xie and Lee Jia*
DOI: 10.2174/1568009618666180817095331

Efficacy and Safety of Antigen-specific Immunotherapy in the Treatment of Patients with Non-small-cell Lung Cancer: A Systematic Review and Meta-analysis

Volume: 19   Issue: 3
Pp: 199-209
Bing-Di Yan, Xiao-Feng Cong, Sha-Sha Zhao, Meng Ren, Zi-Ling Liu, Zhi Li, Chen Chen and Lei Yang*
DOI: 10.2174/1568009618666180430124738

Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics

Volume: 19   Issue: 2
Pp: 82-100
Yuan Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*
DOI: 10.2174/1568009618666180430130248

Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate

Volume: 19   Issue: 1
Pp: 65-73
Marzieh Ghanemi, Aminollah Pourshohod, Mohammad Ali Ghaffari, Alireza kheirollah, Mansour Amin, Majid Zeinali* and Mostafa Jamalan*
DOI: 10.2174/1568009617666170427105417

Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in ApcMin/+ Mice

Volume: 18   Issue: 9
Pp: 905-911
Ashish Saxena, Ravinder Tammali, Kota V. Ramana and Satish K. Srivastava*
DOI: 10.2174/1568009617666170808105633

p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents

Volume: 18   Issue: 8
Pp: 749-772
Surendra Kumar Nayak*, Gopal L. Khatik, Rakesh Narang, Vikramdeep Monga and Harish Kumar Chopra
DOI: 10.2174/1568009617666170623111953

Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention

Volume: 18   Issue: 7
Pp: 640-651
Sadegh Babashah*, Babak Bakhshinejad, Maryam Tahmasebi Birgani, Katayoon Pakravan and William C. Cho*
DOI: 10.2174/1568009617666170623124710

Oncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the Regression of Human Melanoma Tumors in the Absence of T Cells

Volume: 18   Issue: 6
Pp: 577-591
Tiantian Zhang, Dennis H. Kordish, Yogesh R. Suryawanshi, Rob R. Eversole, Steven Kohler, Charles D. Mackenzie and Karim Essani*
DOI: 10.2174/1568009617666170630143931

The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality

Volume: 18   Issue: 5
Pp: 480-498
Sebastiano Bordonaro, Massimiliano Berretta, Antonino Carmelo Tralongo, Silvia Clementi, Brigida Stanzione and Paolo Tralongo*
DOI: 10.2174/1568009617666170209100322

Cell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted Therapy

Volume: 18   Issue: 4
Pp: 347-354
Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying* and Yi Ba*
DOI: 10.2174/1568009617666170710120311

Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance

Volume: 18   Issue: 3
Pp: 295-303
Lin-Jie Li , Yi-Long Wang, Lin-Qing Yuan, Wei-Zhong Gu, Kun Zhu, Min Yang, Duo Zhou, Yao Lv, Min-Ju Li, Zheng-Yan Zhao, Jin-Hu Wang* and Xi Chen*
DOI: 10.2174/1568009617666170330105433

Oncolytic Viruses: The Best is Yet to Come

Volume: 18   Issue: 2
Pp: 109-123
Chantal G. Lemay, Brian A. Keller, Robert E. Edge, Masato Abei and John C. Bell*
DOI: 10.2174/1568009617666170206111609

Coinhibitory Molecule PD-1 as a Therapeutic Target in the Microenvironment of Multiple Myeloma

Volume: 17   Issue: 9
Pp: 839-845
Djordje Atanackovic, Tim Luetkens, Sabari Radhakrishnan and Nicolaus Kroger*
DOI: 10.2174/1568009617666170906170348

Potential Therapeutic Targets in Energy Metabolism Pathways of Breast Cancer

Volume: 17   Issue: 8
Pp: 707-721
Rowshan Ara Islam, Sazzad Hossain and Ezharul Hoque Chowdhury*
DOI: 10.2174/1568009617666170330150458

Epstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of Oncogenesis

Volume: 17   Issue: 6
Pp: 534-554
Abigail Morales-Sanchez and Ezequiel M. Fuentes-Panana*
DOI: 10.2174/1568009616666160926124923

Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer

Volume: 17   Issue: 5
Pp: 479-485
Vinay K. Venishetty, Werner J. Geldenhuys, Tori B. Terell-Hall, Jessica I.G. Griffith, Gregory R. Sondag, Fayez F. Safadi and Paul R. Lockman*
DOI: 10.2174/1568009617666161121123948

Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy

Volume: 17   Issue: 3
Pp: 236-254
Drew A. Spencer, Brenda M. Auffinger, Jason P. Murphy, Megan E. Muroski, Jian Qiao, Yureve Gorind and Maciej S. Lesniak
DOI: 10.2174/1568009616666161215161924

Targeting Key Metabolic Enzymes Involved in Lipid and Protein Biosyntheses for Breast Anticancer Therapies

Volume: 17   Issue: 2
Pp: 158-168
Mounia Guerram, Aida Mejda Hamdi, Lu-Yong Zhang and Zhenzhou Jiang
DOI: 10.2174/1568009616666160603123014

Does Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated Locally Advanced Breast Cancer?

Volume: 17   Issue: 1
Pp: 62-73
Sofia Braga, Joana Cardoso, Saudade Andre, Margarida Brito, Pedro Sanchez, Lurdes Orvalho, Lucilia Salgado, Sergio Dias, Jose B. Pereira-Leal and Jose Luis Passos-Coelho
DOI: 10.2174/1568009616666161025114914

Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening

Volume: 16   Issue: 9
Pp: 818-828
Amit Sharma, Nidhi Jyotsana, Courteney K. Lai, Anuhar Chaturvedi, Razif Gabdoulline, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, Michael Morgan and Michael Heuser
DOI: 10.2174/1568009616666160617103301

Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?

Volume: 16   Issue: 8
Pp: 652-658
Monika Podhorecka, Arkadiusz Macheta, Maria Bozko, Andrzej Bozko, Nisar P. Malek and Przemyslaw Bozko
DOI: 10.2174/1568009616666160427103930

MT1-MMP Activation of TGF-β Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer

Volume: 16   Issue: 7
Pp: 618-630
Hoang-Lan Nguyen, Pournima Kadam, Alex Helkin, Kevin Cao, Song Wu, Ghassan J. Samara, Qian Zhang, Stanley Zucker and Jian Cao
DOI: 10.2174/1568009616666160216125634

Recent Advances in Site Specific Conjugations of Antibody Drug Conjugates (ADCs)

Volume: 16   Issue: 6
Pp: 469-479
Wenlong Gao, Jingxin Zhang, Jun Xiang, Lei Zhang, Chengbin Wu, Pradeep K. Dhal and Bo Chen
DOI: 10.2174/1568009616666160512144715

Mechanisms and Therapeutic Targets of microRNA-associated Chemoresistance in Epithelial Ovarian Cancer

Volume: 16   Issue: 5
Pp: 429-441
Lingyun Zhang, Lubna Nadeem, Kristin Connor and Guoxiong Xu
DOI: 10.2174/1568009616666160404121105

Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin

Volume: 16   Issue: 4
Pp: 288-304
Zhipeng Zou, Juan Chen, Jun Yang and Xiaochun Bai
DOI: 10.2174/1568009616666151113120830

Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma

Volume: 16   Issue: 3
Pp: 261-274
Marilù Fanelli, Claudia Maria Hattinger, Serena Vella, Elisa Tavanti, Francesca Michelacci, Beth Gudeman, Daryl Barnett, Piero Picci and Massimo Serra
DOI: 10.2174/1568009616666151106120434

RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer

Volume: 16   Issue: 2
Pp: 157-174
Chiharu Uchida and Masatoshi Kitagawa
DOI: 10.2174/1568009616666151112122801

Molecular Genetics and Targeted Therapy in Hepatocellular Carcinoma promotion: free to download

Volume: 16   Issue: 1
Pp: 53-70
Eric I. Marks and Nelson S. Yee
DOI: 10.2174/1568009615666150916092903

Nanobiotechnological Approaches to Overcome Drug Resistance in Breast Cancer

Volume: 15   Issue: 7
Pp: 544-562
Peyman Ranji, Zahra Heydari and Ali Mohammad Alizadeh
DOI: 10.2174/1568009615666150706102842

Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer

Volume: 15   Issue: 6
Pp: 469-480
Lewis Quayle, Penelope D. Ottewell and Ingunn Holen
DOI: 10.2174/1568009615666150506092443

Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer

Volume: 15   Issue: 5
Pp: 394-405
Ryan Stuchbery, Natalie J. Kurganovs, Patrick J. McCoy, Colleen C. Nelson, Vanessa M. Hayes, Niall M. Corcoran and Christopher M. Hovens
DOI: 10.2174/1568009615666150416113453

A Pan-Cancer Review of ALK Mutations: Implications for Carcinogenesis and Therapy

Volume: 15   Issue: 4
Pp: 327-336
Nick Ka Ming Yau, Andrew Yuon Fong, Hiu Fung Leung, Krista Roberta Verhoeft, Qin Ying Lim, Wai Yip Lam, Ian Chi Kei Wong and Vivian Wai Yan Lui
DOI: 10.2174/1568009615666150225123712

Present, Emerging and Possible Future Biomarkers in Castration Resistant Prostate Cancer (CRPC)

Volume: 15   Issue: 3
Pp: 243-255
Martin Boegemann, Andres-Jan Schrader, Laura-Maria Krabbe and Edwin Herrmann
DOI: 10.2174/1568009615666150204145803

Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases

Volume: 15   Issue: 2
Pp: 88-98
Astra I. Chang, Aaron H. Schwertschkow, Jan A. Nolta and Jian Wu
DOI: 10.2174/1568009615666150126154151

Potential Anti-cancer Drugs Commonly Used for Other Indications promotion: free to download

Volume: 15   Issue: 1
Pp: 35-52
Veronika Hanusova, Lenka Skalova, Vera Kralova and Petra Matouskova
DOI: 10.2174/1568009615666141229152812

Looking out for Cancer Stem Cells’ Properties: The Value-Driving Role of CD44 for Personalized Medicines

Volume: 14   Issue: 9
Pp: 832-849
Sara Horta, Ana L. Agostinho, Rita Mateus, Lucilia Pereira, Carolina Pereira, Liliana Capinha, Slavomira Doktorovova, Alexandra Brito and Mafalda Videira
DOI: 10.2174/1568009614666141111154713

Heat Shock Proteins as Prognostic Markers of Cancer

Volume: 14   Issue: 8
Pp: 713-726
Evgeniya V. Kaigorodova and Mariya V. Bogatyuk
DOI: 10.2174/1568009614666140926122846

Targeting Oncogenes and Tumor Suppressors genes to Mitigate Chemoresistance

Volume: 14   Issue: 7
Pp: 599-609
Tahereh Fatemian and Ezharul Hoque Chowdhury
DOI: 10.2174/156800961407140926104458

The Activation of β1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer

Volume: 14   Issue: 5
Pp: 446-457
Wanxing Duan, Jiguang Ma, Qingyong Ma, Qinhong Xu, Jianjun Lei, Liang Han, Xuqi Li, Zheng Wang, Zheng Wu, Shifang Lv, Zhenhua Ma, Mouzhu Liu, Fengfei Wang and Erxi Wu
DOI: 10.2174/1568009614666140402105101

Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Volume: 14   Issue: 4
Pp: 357-370
Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier
DOI: 10.2174/1568009614666140407113124

Targeting BMP9-Promoted Human Osteosarcoma Growth by Inactivation of Notch Signaling

Volume: 14   Issue: 3
Pp: 274-285
Ruidong Li, Wenwen Zhang, Jing Cui, Wei Shui, Liangjun Yin, Yang Wang, Hongyu Zhang, Ning Wang, Ningning Wu, Guoxin Nan, Xian Chen, Sheng Wen, Fang Deng, Hongmei Zhang, Guolin Zhou, Zhan Liao, Junhui Zhang, Qian Zhang, Zhengjian Yan, Wei Liu, Zhonglin Zhang, Jixing Ye, Youlin Deng, Hue H. Luu, Rex C. Haydon, Tong-Chuan He and Zhong-Liang Deng
DOI: 10.2174/1568009614666140305105805