Abstract
Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.
Keywords: Nitric Oxide, Apoptosis, Nitric Oxide Synthase, Tumour Cells
Current Pharmaceutical Design
Title: Nitric Oxide and the Regulation of Apoptosis in Tumour Cells
Volume: 12 Issue: 34
Author(s): J. M. Tarr, P. Eggleton and P. G. Winyard
Affiliation:
Keywords: Nitric Oxide, Apoptosis, Nitric Oxide Synthase, Tumour Cells
Abstract: Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.
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Cite this article as:
Tarr M. J., Eggleton P. and Winyard G. P., Nitric Oxide and the Regulation of Apoptosis in Tumour Cells, Current Pharmaceutical Design 2006; 12 (34) . https://dx.doi.org/10.2174/138161206779010477
DOI https://dx.doi.org/10.2174/138161206779010477 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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