Abstract
In this review we will briefly survey the oxidation chemistry of the catechol estrogens (2-hydroxy- and 4- hydroxyestradiol, 2-OH-E and 4-OH-E) as a result of the research carried out in the authors laboratory and other centers during the past decade. The central focus of the paper will be on the main pathways of oxidative modification and their possible relevance to the mechanisms of estrogen-related carcinogenesis. The chemical bases underlying the different reactivity and toxicity of 2-hydroxy and 4-hydroxyestradiol will be addressed. The value of catechol estrogen oxidation in the discovery of novel functionalized or modified steroidal scaffolds of potential pharmaceutical interest will be also briefly highlighted.
Keywords: Estradiol, catechol estrogen, tyrosinase, peroxidase, carcinogenesis, oxidation, o-quinone(s)
Current Bioactive Compounds
Title: Preparation and Oxidation Chemistry of the Catechol Estrogens: Relevance to Estrogen-Related Carcinogenesis and Potential for Drug Design
Volume: 2 Issue: 4
Author(s): Alessandro Pezzella, Liliana Lista, Alessandra Napolitano and Marco d'Ischia
Affiliation:
Keywords: Estradiol, catechol estrogen, tyrosinase, peroxidase, carcinogenesis, oxidation, o-quinone(s)
Abstract: In this review we will briefly survey the oxidation chemistry of the catechol estrogens (2-hydroxy- and 4- hydroxyestradiol, 2-OH-E and 4-OH-E) as a result of the research carried out in the authors laboratory and other centers during the past decade. The central focus of the paper will be on the main pathways of oxidative modification and their possible relevance to the mechanisms of estrogen-related carcinogenesis. The chemical bases underlying the different reactivity and toxicity of 2-hydroxy and 4-hydroxyestradiol will be addressed. The value of catechol estrogen oxidation in the discovery of novel functionalized or modified steroidal scaffolds of potential pharmaceutical interest will be also briefly highlighted.
Export Options
About this article
Cite this article as:
Pezzella Alessandro, Lista Liliana, Napolitano Alessandra and d'Ischia Marco, Preparation and Oxidation Chemistry of the Catechol Estrogens: Relevance to Estrogen-Related Carcinogenesis and Potential for Drug Design, Current Bioactive Compounds 2006; 2 (4) . https://dx.doi.org/10.2174/157340706778992555
DOI https://dx.doi.org/10.2174/157340706778992555 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Design, Synthesis and Biological Evaluation of Novel 4-phenoxypyridine Derivatives Containing Semicarbazones Moiety as Potential c-Met Kinase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry The Insulin-like Growth Factor-1 Axis and its Potential as a Therapeutic Target in Central Nervous System (CNS) Disorders
Central Nervous System Agents in Medicinal Chemistry Pharmacophore Based 3D-QSAR Study of Biphenyl Derivatives as Nonsteroidal Aromatase Inhibitors in JEG-3 Cell Lines
Medicinal Chemistry Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
Current Pharmaceutical Design Cancer: A Problem of Developmental Biology; Scientific Evidence for Reprogramming and Differentiation Therapy
Current Drug Targets Glycoconjugates As Vaccines for Cancer Immunotherapy: Clinical Trials and Future Directions
Anti-Cancer Agents in Medicinal Chemistry Editorial [Hot Topic: An Up-Date of Olive Oil and Bioactive Constituents in Health: Molecular Mechanisms and Clinical Implications (Executive Guest Editor: Catalina Alarcon de la Lastra Romero)]
Current Pharmaceutical Design Agents Targeting Prostate Cancer Bone Metastasis
Anti-Cancer Agents in Medicinal Chemistry Polyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation
Current Molecular Pharmacology Meet Our Editorial Board Member
The Natural Products Journal The Emerging Role of CSN6 in Biological Behavior and Cancer Progress
Anti-Cancer Agents in Medicinal Chemistry Destabilizing Aneuploidy by Targeting Cell Cycle and Mitotic Checkpoint Proteins in Cancer Cells
Current Drug Targets Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs
Current Pharmaceutical Design The HGF-Met Signaling Axis: Emerging Themes and Targets of Inhibition
Current Protein & Peptide Science Potential Role of PKC Inhibitors in the Treatment of Hematological Malignancies
Current Pharmaceutical Design The Genomics of Colorectal Cancer: State of the Art
Current Genomics Verification between Original and Biosimilar Therapeutic Antibody Infliximab Using nSMOL Coupled LC-MS Bioanalysis in Human Serum
Current Pharmaceutical Biotechnology The Role of Infection in Carotid Plaque Pathogenesis and Stability: The Clinical Evidence
Current Vascular Pharmacology Expression Level and Hormonal Regulation of ABC Transporters in Breast Cancer
Current Cancer Therapy Reviews The Role of Diabetes in Molecular Pathogenesis of Cancer
Current Signal Transduction Therapy