Abstract
DNA helicases have historically been implicated in the initiation or elongation phases of DNA replication; however, elegant studies in prokaryotic systems have suggested more specialized functions of helicases to stabilize the replication fork when DNA replication is impeded. More recently, it has become increasingly evident that eukaryotic DNA helicases function at replication forks to participate in processes that include DNA damage detection and signaling, resolution of alternate DNA structures, fork regression, and replication restart. Genetic and biochemical studies have begun to elucidate the molecular roles of DNA helicases at the replication fork in the coordination of the synthesis and processing of leading and lagging strand, a vital function to preserve genomic integrity. In addition, ATP-dependent chromatin remodeling by helicase-like proteins during replication initiation, elongation, or restart may have important roles as well. These themes will be discussed with an emphasis on the cellular mechanisms of DNA helicases/chromatin remodeling enzymes implicated in human disease and proposed to function with other protein factors during replication.
Keywords: Helicase, replication, chromatin remodeling, genomic instability
Current Genomics
Title: The Emerging Importance of DNA Helicases to Stabilize the Replication Fork
Volume: 7 Issue: 6
Author(s): Rigu Gupta, Sudha Sharma and Robert M. Brosh
Affiliation:
Keywords: Helicase, replication, chromatin remodeling, genomic instability
Abstract: DNA helicases have historically been implicated in the initiation or elongation phases of DNA replication; however, elegant studies in prokaryotic systems have suggested more specialized functions of helicases to stabilize the replication fork when DNA replication is impeded. More recently, it has become increasingly evident that eukaryotic DNA helicases function at replication forks to participate in processes that include DNA damage detection and signaling, resolution of alternate DNA structures, fork regression, and replication restart. Genetic and biochemical studies have begun to elucidate the molecular roles of DNA helicases at the replication fork in the coordination of the synthesis and processing of leading and lagging strand, a vital function to preserve genomic integrity. In addition, ATP-dependent chromatin remodeling by helicase-like proteins during replication initiation, elongation, or restart may have important roles as well. These themes will be discussed with an emphasis on the cellular mechanisms of DNA helicases/chromatin remodeling enzymes implicated in human disease and proposed to function with other protein factors during replication.
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Cite this article as:
Gupta Rigu, Sharma Sudha and Brosh M. Robert, The Emerging Importance of DNA Helicases to Stabilize the Replication Fork, Current Genomics 2006; 7 (6) . https://dx.doi.org/10.2174/138920206778948709
DOI https://dx.doi.org/10.2174/138920206778948709 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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