Abstract
While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.
Keywords: Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants
Current Drug Targets
Title: Towards a Life Prolonging Pill? Small Molecules with Anti-Ageing Properties
Volume: 7 Issue: 11
Author(s): Manuchair Wagner
Affiliation:
Keywords: Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants
Abstract: While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.
Export Options
About this article
Cite this article as:
Wagner Manuchair, Towards a Life Prolonging Pill? Small Molecules with Anti-Ageing Properties, Current Drug Targets 2006; 7 (11) . https://dx.doi.org/10.2174/1389450110607011531
DOI https://dx.doi.org/10.2174/1389450110607011531 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Class II Phosphoinositide 3-Kinases as Potential Novel Drug Targets
Current Signal Transduction Therapy Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases
Current Genomics Immunomodulatory Effects of Medicinal Plants used for Vitiligo in Traditional Persian Medicine
Current Drug Discovery Technologies Glycosidated Phospholipids – a Promising Group of Anti-Tumour Lipids
Anti-Cancer Agents in Medicinal Chemistry PET Studies with Carbon-11 Radioligands in Neuropsychopharmacological Drug Development
Current Pharmaceutical Design Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies
Current Stem Cell Research & Therapy Alzheimer’s Disease And Type 2 Diabetes: Exploring The Association To Obesity And Tyrosine Hydroxylase
CNS & Neurological Disorders - Drug Targets Mind-Body Therapies and Osteoarthritis of the Knee
Current Rheumatology Reviews Targeting Metallothionein for Prognosis and Treatment of Breast Cancer
Recent Patents on Anti-Cancer Drug Discovery Targeting Myocardial Metabolism for the Treatment of Stable Angina
Current Pharmaceutical Design The Effects of Stimulation with PMA/Ionomycin on CD4+ T Cell Proliferation and Surface CD4 Molecule Modulation of Patients with LRBA Deficiency and CVID with the Unsolved Genetic Defect
Endocrine, Metabolic & Immune Disorders - Drug Targets Membrane and Soluble Forms of Endoglin in Preeclampsia
Current Molecular Medicine Preface:
Current Topics in Medicinal Chemistry Leptin and Interleukin-1β Modulate Neuronal Glutamate Release and Protect Against Glucose-Oxygen-Serum Deprivation
Current Neurovascular Research Adipose Tissue-Derived Multi-lineage Progenitor Cells as a Promising Tool for In Situ Stem Cell Therapy
Current Tissue Engineering (Discontinued) Brain Serotonin, Psychoactive Drugs, and Effects on Reproduction
Central Nervous System Agents in Medicinal Chemistry Ethnicity Considerations in Diagnosing Glucose Disorders
Current Diabetes Reviews Impact of Nanomaterials on High Throughput Separation Methodologies
Combinatorial Chemistry & High Throughput Screening Literature Review: Use of Family History for Primary Paediatric Care as the Next Step Towards use of Genomics in Healthcare
Current Pediatric Reviews Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection
Current Immunology Reviews (Discontinued)