ISSN (Print): 1573-4110
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Volume 17, 9 Issues, 2021
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ISSN (Print): 1573-4110
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Special Issue Submission
"Serious and independent sources of information such as Current Analytical Chemistry are desired and will expand the knowledge in qualitative as well as quantitative analytical operations."
Submit Abstract via Email
It was my first submission and my experience of working with Bentham Science Publishers remained excellent. I found prompt and supporting response at every step. I felt pleasure to share this wonderful experience with my colleagues. I am really grateful for whole team of Bentham Science Publishers for their timely support.
Muhammad Aslam Mirza (Department of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur-10250 (AJK), Pakistan.)
Has contributed: Investigation of Antioxidant Activity and Trace Metals in Medicinal Plants in Kashmir, Pakistan.
3 Abstract Ahead of Print are available electronically
48 Articles Ahead of Print are available electronically
We sincerely introduce the thematic issue Volume II entitled " Revisiting Pharmaceutical Analysis in the Light of New
Technologies - Volume II" by us, Prof. Sibel A. Ozkan, Prof. Bengi Uslu, Assoc. Prof. Dr. Sevinc Kurbanoglu, and Dr. Burcin
The main aim of the issue is to review innovative developments in drug analysis related to all analytical techniques for
pharmaceutical analyses, such as liquid chromatography, solid-phase extraction, spectroscopy, chemometrics, electrochemical
methods, etc. This special issue contributes to the field since the recent developments in pharmaceutical analyses are significant
and continuous. This special issue in “Current Analytical Chemistry” combines different analytical methods, supports the
prosperity of analytical chemistry, and develops new analytical techniques to help in important pharmaceutical studies. This
special issue will contribute to the different fields of chemistry since the recent developments in multidisciplinary topics are
significant and continuous. In this thematic issue Volume II, there are 8 review papers.
In the first review paper, recent applications of nanomaterials based on electrochemical drug analysis are reviewed by
Senturk et al. Nanotechnology has recently come to the forefront of analytical chemistry . A large number of nanomaterials
have found a wide range of applications in various analytical methodologies. Çelebier and Nenni also contributed to our special
issue by reviewing recent developments in capillary electrophoresis-mass spectrometry-based metabolomics . The current
situation and the challenges facing metabolomic studies are discussed to reveal the high potential of capillary electrophoresismass
spectrometry for further studies, especially in biomarker development studies. Çelebier and Ercan also reviewed recent
approaches to integrate multi-omics data on systems biology . The authors stated that the clinical perspective of the
researches using omics techniques might be supported with the integration of multi-omics data to validate the results and to
understand the molecular pathway interaction in the biological system.
Gokbulut also contributed to our special issue by reviewing the recent studies about high-performance thin-layer
chromatography to investigate medicinal plants . In this review, the latest perspective was established. Some of the previous
studies were summarized for the usage of high-performance thin-layer chromatography in the analysis of herbal remedies,
dietary supplements, and nutraceuticals. An overview of green chromatographic analysis from pharmaceutical preparations was
contributed in this special issue by Dogan et al. The authors stated that, while one cannot wholly convert the research to the
green, the steps taken to do so are precious, particularly in the wide-range uses in high-performance liquid chromatography
both in drug quality control laboratories in industry and research studies .
Analysis of quinolones in biological materials by liquid chromatography is also reviewed by Gök et al. Quinolones are an
essential group of synthetic antibiotics with bactericidal action . In another contribution, aspects of matrix effects in liquid
chromatography-mass spectrometry applications to catecholamine analysis are reviewed by Ozcan et al. This review focuses on
these issues, critically discussing experimental results of matrix effects in liquid chromatography based on tandem mass
spectrometry applications on catecholamine analysis in various biological matrices . Lastly, electrochemical analysis for
pharmaceuticals by the advantages of metal oxide nanomaterials is reviewed by Bozal-Palabiyik et al., In the last decade, metal
oxides are frequently used in electrochemical drug analysis as electrode modifiers individually and with other nanomaterials,
especially carbon-based ones .
In this special issue Volume II, we collected several kinds of review papers investigated by different authors to show the
richness of drug researches. Therefore, this thematic issue will be beneficial for researchers that aim to have a broad
knowledge. We would like to thank all of the authors one more time for their excellent contributions and the Editors of
“Current Analytical Chemistry” for kindly inviting us as the guest editors for this thematic issue. Moreover, we are thankful for
the valuable assistance by Editorial Manager, Syed Faizan Akhtar, in the processing and finalization of this special theme issue.
We cordially invite you to meet the thematic issue volume I titled "Revisiting Pharmaceutical Analysis in the Light of New
Technologies" by us, Prof. Sibel A. Ozkan, Prof. Bengi Uslu, Assoc. Prof. Dr. Sevinc Kurbanoglu, and Dr. Burcin Bozal
The main aim of the issue is to review innovative developments in drug analysis related to all analytical techniques for
pharmaceutical analyses such as liquid chromatography, solid-phase extraction, spectroscopic, chemometric, electrochemical
methods, etc. This special issue contributes to the field since the recent developments in pharmaceutical analyses are significant
and continuous. This special issue in “Current Analytical Chemistry” combines all different analyzing methods, supports the
prosperity of analytical chemistry, and develops new analytical techniques to help the importance of pharmaceutical studies.
This special issue will contribute to the different fields of chemistry since the recent developments in multidisciplinary topics
are significant and continuous. In this thematic issue volume I, there exist 8 review papers.
In the first review paper aims to provide an overview of the modern analytical techniques currently used for the drug
delivery systems characterization, with a focus on those commonly used by Rus et al. Telkoparan-Akillilar, and Cevik also
contributed a review to this special issue titled “The applications of next-generation sequencing in drug development for cancer
therapy.” The authors focus on current and potential applications of NGS in various stages of the drug discovery process, from
target identification to personalized medicine. “Raman spectroscopy as a novel technology in forensic toxicological analyses” is
also reviewed by Akçan and Yıldırım, as the Raman Spectroscopy becomes a promising tool in forensic toxicology with the
increasing number of studies in the literature. In their paper, the forensic toxicological studies carried out using Raman
spectroscopy are reviewed and discussed with the findings and suggestions made regarding the use and research of Raman
spectroscopy in the field of forensic toxicology for future applications.
In another contribution, by Kilińska and Zalewski, radiation sterilization which is a promising method of obtaining sterile
active pharmaceutical ingredients, excipients, and formulations, is discussed. The authors stated that one of the best methods of
sterilization is to use ionizing radiation. The most significant advantage of ionizing radiation is that it can be conducted at room
temperature or lower. Therefore, this procedure of sterilization is reserved for drugs sensitive to the high temperature of
autoclaving. A review of voltammetric methods for determining dopamine agonists is also an interesting review paper in our
special issue by Ağın. This review includes various voltammetric methods for studying dopamine agonists from pharmaceutical
dosage forms and biological samples. These studies were examined using voltammetric methods, working electrodes, buffer,
pH, and validation parameters.
Additionally, D’Orazio et al. contributed to this thematic issue by a paper titled “Innovative solutions for the extraction of
vitamins from pharmaceutical and biological samples. The authors stated that the great potential of microextraction techniques
based on nanomaterials and neoteric solvents had not been fully exploited yet in the clinical and pharmaceutical fields.
Considering the high cost of carbon-based nanomaterials, it can be expected that liquid microextraction techniques based on
neoteric solvents will be more effective for sample preparation soon. Thanks to their low cost, environmental compatibility,
simplicity, speediness, and high enrichment factor, these extractive techniques are particularly significant for vitamin analysis.
In an additional contribution, Akçan et al. presented novel technologies and nanotoxicology of medical implants. A detailed
review of related literature is performed and evaluated as per nanomaterials and medical implants by the authors. Cini and
Golcu reviewed the recently studied spectrophotometric methodologies applied for the determination of pharmaceuticals.
Selected examples demonstrating the applicability of spectrophotometric methods in pharmaceutical assays in this review might
contribute to the overall importance of the analytical test used in modern pharmaceutical analysis.
In this special issue volume I, we collected several kinds of review papers investigated by different authors to show the
riches of drug researches. Therefore, this thematic issue will be beneficial for the researchers that wanted to have a broad
knowledge. We would like to thank all of the authors one more time for their excellent contributions, the Editors of “Current
Analytical Chemistry” for this kind invitation to act us as guest editors for this thematic issue and especially the valuable
assistance by Editorial Manager Syed Faizan Akhtar in the processing and finalization of this special theme issue.
Volume III of the thematic issue has 3 review papers and 6 research papers. Currently, pollution and scarcity of freshwater
threaten human health and natural ecosystems. Among the various water treatment materials, biomass is effective for the removal
of contaminants from water, including dyes, pharmaceutical residues, heavy metal ions, etc. Biomass attracted the interest
of several researchers in contrast to non-renewable resources attributed to their numerous inherent properties such as renewability,
non-toxic nature, biocompatibility, and ease in biodegradability, which pave the way to achieve environmental sustainability.
The first review by F. Mashkoor and A. Nasar deals with the utilization of agro-waste derived adsorbents for the elimination
of dyes from wastewater. It also includes the effect of various batch factors such as adsorbate/adsorbent contact time, pH of the
solution, initial concentration of the dye, adsorbent dose, the temperature on the adsorption process. Thermodynamic, isotherm
and kinetics have been systematically surveyed and compiled . Recent trends and applications of cellulose nanofibers from
lignocellulosic biomass are discussed by R. Majumdar. In this review, cellulose nanoscale materials and their various preparation
methods, properties, reinforcing with other materials and biocomposite applications have also been discussed . The other
review focuses on imidazolium-based ionic liquids as a green solvent and catalyst to depolymerize lignin models, especially
guaiacol glyceryl ether (GGE) (Guaifenesin). Subsequently, base-catalyzed, acid-catalyzed, metallic catalyzed, supercritical
fluids, and ionic liquids-assisted methods are summarized for lignin degradation .
Mashkoor et al., develop a process for the utilization of Luffa aegyptiaca peel (LuAP) as a potential, economical, and sustainable
adsorbent for the removal of methylene blue (MB) dye from the aqueous solution . El-Shishtawy et al., report the
removal of toxic dyes, anionic and cationic dyes (Acid Red 1 and methylene blue (MB) from aqueous solution by amphoteric
bioadsorbent, i.e., modified chitin. The adsorption behavior of amphoteric chitin is believed to follow chemical adsorption with
an ion-exchange process. The recycling process for few cycles indicates that the loaded adsorbent can be regenerated by simple
treatment and retested for removing anionic and cationic dyes without any loss in the adsorbability. Therefore, the study introduces
a new and easy approach for the development of amphoteric adsorbent for application in the removal of different dyes
from aqueous solutions . Fathy et al., report sugarcane bagasse hydrochar (SCB) derived carbon nanostructures (CNSs) for
removing toxic Cr(VI) ions from aqueous solutions. Two modified CNSs samples were successfully prepared from SCB. Adsorption
of Cr(VI) highly relies on the initial concentration of Cr(VI), pH, and temperature. The main factors controlling the
adsorption behavior of Cr(VI) are the acidic functional groups and the accessible surface area on O-CNSs. Furthermore, the OCNSs
attain high stability in recycling tests for Cr(VI) removal . Ayyappa et al., conduct their research on novel background
electrolytes supported with DFT calculations and successfully applied to separate sucralose in food samples using an indirect
UV detector with capillary electrophoresis. Computational results indicate that the direction of charge transfer from the amine
functionality to the glucofuranosyl ring in each amine derivative of sucralose confirms the strong interaction between sucralose
and amines, which leads to the baseline separation of sucralose in different food samples . Madhura et al., design a quantitative
structure-activity relationship (QSAR) model for the removal of 57 pharmaceuticals and personal care products (PPCPs)
from wastewater treatment plants (WWTPs). The target compounds of PPCPs are optimized geometrically using a Forcite-
Geometry code, assembled in Material Studio 2016 . Mohsina et al., report the removal of MB dye from synthetically polluted
water by jackfruit peel bio adsorbent. It is derived from agriculture waste, a novel and economically feasible adsorbent for
the removal of MB from aqueous solutions .
In summary, the reviews and research papers presented in this issue are concerned with the removal of toxic pollutants from
the environment by the utilization of biomass materials. We offer readers very interesting practical solutions to experimental
results, and theoretical research contributions by several authors in the analytical chemistry field. It is fascinating research to
readers. We wish all our readers a fruitful reading.
Toxic pollutants in the environment are of concern because of their negative impact on human health and ecosystems. Sustainability
and environmental issues have influenced scientists and researchers to work on ecological materials, and this decade has witnessed
a remarkable improvement in sustainable chemical engineering. Volume II of the thematic issue has six review papers and three research
Wang et al., review the aspects of the design and synthesis of new emerging two-dimensional MXene-based membranes, processes
development, and recent explorations in water treatment. Various preparation methods of MXene-based membranes, as well as their
separation behaviors in water purification and desalination, are briefly discussed and analyzed . The second review article of Nazir
et al., gives an overview of the remediation of heavy metals from aqueous solutions using green biocomposites. It includes advanced
techniques, synthesis protocols, important factors and application of biopolymers and their composites, and recent advancements in
biopolymers . Kaur et al., report a review on the chromatographic techniques for the analysis of Metformin (in ng/L to μg/L) in
aqueous samples, pharmaceutical drugs and biological fluids such as urine and human plasma using high-performance liquid chromatography
(HPLC), reverse-phase high-performance liquid chromatography (RP-HPLC), and high-performance thin-layer chromatography
. Tang et al., conduct a review to explore the latest developments in various pretreatment technologies, key scientific problems,
and the current status of different residual drugs in environmental samples because sample pretreatment has always been the
bottleneck restricting the development of residual drug analysis . Vallidevi et al., perform a detailed and comparative analysis of
sensor-based water quality monitoring with a Geographical Information System (GIS) for the efficient detection of water pollutants.
Further research in this field may introduce many advancements to develop efficient water pollution detection techniques . Nazir
et al., summarize various techniques for desulfurization of diesel oil to remove sulfur-containing compounds from diesel, highlighting
the recent advancements in the process of desulfurization of diesel oil to explore less energy-intensive and more economical processes
. Martínez et al., synthesize manganese oxides in the powder form and coatings were tested for lead ions adsorption capacities .
Kanchi et al., demonstrate the utilization of ammonium morpholine-4-carbodithioate (AMC) as a separation enhancement ligand. The
present study aims to develop a selective and sensitivity enhancement separation protocol for transition elements in agricultural materials
. Arunkumar et al., report the fracture toughness of silicon carbide by varying the composition of MWCNT and ceramics using
spark plasma sintering. The fabricated nanocomposites are characterized by analytical techniques and different mechanical properties
such as relative density, hardness, and impact strength as per ASTM standards .
The scope of these works presented in this Volume II offers an original insight into the progress made across a wide range of sustainable
chemical engineering techniques for toxic pollutants in the environment within the field of analytical chemistry. I hope these
high-quality articles in this volume II could provide valuable information to students, engineers, and researchers working on analytical
Environmental pollution has become a serious concern throughout the world. Therefore, decontamination of wastewater and
removal of organic pollutants from the environment by photo/electro/biochemical approaches have emerged as one of the most
promising techniques. The special issue of the “Current Analytical Chemistry” journal, named “Toxic Pollutants in the Environment:
Challenges in Analytical Chemistry” includes three volumes that will cover various analyzing approaches to the prosperity
of analytical chemistry towards environmental remediation applications. We would like to thank Prof. Samuel Achilefy,
Editor-in-Chief of the “Current Analytical Chemistry” for accepting a proposal related to this special issue and many thanks to
the Editorial Manager, Syed Faizan Akhtar, for the kind help in all steps relating to the production of the selected articles. And
also great thanks to world-renowned scientists for their valuable contributions to this special issue.
Volume I of the thematic issue contains ten manuscripts; two review papers and eight research papers reporting on recent
trends dealing with photo/electro/ biochemical methods, design, properties, characterizations, and analytical applications; from
internationally renowned researchers worldwide, including Ireland, China, India, Malaysia, Taiwan, Pakistan, and Saudi Arabia.
The first review written by Wei et al. deals with the recent developments in CdS cocatalysts for hydrogen production using
water splitting under visible-light irradiation. The factors affecting the photocatalytic performance and new cocatalyst design,
as well as the general classification of cocatalysts, which include a single cocatalyst containing noble metals, non-noble metals,
metal-complex cocatalysts, metal-free cocatalysts, and multi-cocatalysts designing toward the CdS solar-to-hydrogen energy
conversion are described . Another review aimed to provide a detailed discussion about environmental as well as human
health behavior and analytic techniques corresponding to sulphonamides in aqueous solution for suitable wastewater treatment
by Pavithra et al. It also includes determination techniques such as UV-spectroscopy, enthalpimetry, immunosensor, chromatography,
chemiluminescence, photoinduced fluorometric determination and Capillary electrophoresis for sulphonamide determination
Pang et al. designed a series of novel activated carbon/titanium dioxide (AC/TiO2) composites at various weight ratios using
the sol-gel method and AC obtained from empty fruit bunch fibres. The characteristic of the composite material was investigated
and the photocatalytic properties of malachite green dye removal were compared with those of AC and bare TiO2 . A
simple, low cost and highly sensitive catalytic hydrogen wave (CHW) method was developed for the investigation of manganese(
II) in ammonium 4-phenylpiperazine-1-dithiocarbamate and ammonium 4-benzylpiperidine-1-dithiocarbamate in various
environmental and biological samples using direct current polarography by Thondavada et al. The developed CHW method is
highly sensitive, simple and spontaneous for the analysis of Mn(II) in environmental and biological samples. The CHW method
is free from interference effect avoiding the removal stages which are made towards placing among utmost sensitive methods
for the analysis of Mn(II) in different environmental and biological samples . Aslam et al. proposed an investigation to degrade
the harmful pollutants from wastewater, using highly efficient non-toxic Fe2(WO4)3 photocatalyst synthesized via coprecipitation
method. The photocatalytic activity of the as-synthesized material was examined by degrading methylene blue
(MB) under various conditions. This research signifies that this method is useful for the reclamation of water, making it useful
for industry and irrigation . Conventional heavy metal removal from industrial sewages is carried out using numerous treatment
technologies, including nano-filtration, precipitation, reverse osmosis, coagulation and flocculation, adsorption, etc. Rahman
et al. concentrated their study on palm oil-derived biomass waste and an empty fruit bunch was used to prepare a cellulose-
graft copolymer, which can be converted into poly(amidoxime)-poly(hydroxamic acid) ligands suitable for the removal of
heavy metals as well as electroplating wastewater . Ahamed et al. synthesized Kraton/polyaniline ionomer composite membrane
and the same was used for the Cu(II) ion-selective membrane electrode (ISME). The membrane electrode was widely
used for the potentiometric determination of Cu(II) ions . Kunhan et al. investigated an electrode for the powerful, informative,
and non-destructive technique to study the electrical properties of different GdAlO3: Co2+ samples . Priyanka et al. synthesized
different titania (TiO2) nanostructures doped with La3+ and Ce3+ ions under visible light and are tested for their photocatalytic
degradation efficiency under visible light for methylene blue (C16H18ClN3S) and rhodamine blue (C28H31ClN2O3) dyes.
Photocatalytic dye degradation was significantly improved for doped nano titania, particularly for Ce3+ doped nano titania compared
to the pristine sample. In short, crystal phase, crystallite size, crystallinity, morphology, bandgap, and calcination temperature
play key roles in the photocatalytic mechanism . Karanam et al. investigated the anticancer effect of a novel dipeptide
isolated from a marine sponge-associated Bacillus pumilus AMK1 by formulating with Zinc oxide (ZnO) nanoparticles for the
effective treatment against HepG2 liver cancer cells. The experimental results demonstrate that ZnO nanoparticle conjugated
dipeptide has the potential to improve anticancer efficacy against liver cancer cells by inducing apoptosis in cancer cells without
affecting normal liver cells and their toxicity evaluation on embryonic zebrafish .
Overall, the manuscripts published in this special issue present recent developments, various perspectives, and approaches
to the studies of toxic pollutants in the environment. Most of them focus on the use of photo/electro/biochemical approaches for
dyes and heavy metals removal, solar-to-hydrogen energy conversion, and anticancer applications. The work compiled in this
special issue represents an excellent illustration of modern advances reached by the combinations of fundamental research, applied
experimental research and theoretical modeling increasing this knowledge and enabling the progress in toxic pollutants in
the environment using analytical chemistry tools by photo/electro/biochemical approaches. We are confident that this Volume I
will provide readers with an overview of the latest prospects in this rapidly evolving and interdisciplinary field.
Green Analytical Chemistry principles are progressively applied in most analytical methods. Undoubtedly, environmental
analysis is one of the most relevant fields that should take care of the effects of the use of conventional methods and their impact
on the environment.
The scope of this special issue is to describe the state of the art in both analysis and sample pretreatment with regards to the
demands of green perspectives. Analytical scientists were invited to present their new strategies to fulfil all the requirements for
reduction of waste, energy consumption, use of solvents, etc.
Four comprehensive reviews are included in this mini thematic issue [1-4]. More specifically:
Amin et al., in their review “Recent Trends in Development of Green Analytical Methods for the Detection of Environmental
Pollutants using Nanomaterials”, provide information about multiple methods that use green nanomaterials for the analytical
assessment of environmental pollutants. UV-Vis spectrophotometry and electrochemical analysis using green and reproducible
nanomaterials are the major focus of this article. The authors conclude that the use of nanomaterials can drastically change the
detection limits due to the large surface area, strong catalytic properties, and tunable possibility. The used nanomaterials could
be washed, dried, and reused, which make the methods more proficient, cost-effective and environmentally friendly.
Erdem-Yayayürük and Yayayürük, in their review “Recent Advances in Environmental Analysis towards Green Nanomaterials”,
discuss strategies of green chemistry, green chemistry metrics, waste management, green nanotechnology/
nanoscience and characterization. The authors conclude that green synthesis of nanomaterials is a safer, energy-efficient and
fast method that reduces the use of solvent reagents and preservatives, which are hazardous to both environment and human
health. Moreover, the fabrication of nanomaterials using green procedures is a clean, safe, nontoxic, and environmentally
friendly method that increases its necessity and demand in large-scale applications.
Manousi and Zachariadis, in their review “Green Miniaturized Extraction and Microextraction of Polycyclic Aromatic Hydrocarbons
from Foods and Beverages”, discuss the recent advances in the extraction techniques of PAHs from food samples,
utilizing novel sample preparation approaches and adsorbents.
Compared to the traditional sample preparation techniques, the herein discussed green miniaturized extraction and microextraction
techniques offer multiple benefits, including simplicity, reduced sample preparation time, as well as reduced consumption
of organic solvents.
Tsalbouris et al., in their review “Recent advances in miniaturized microextraction techniques for the determination of bisphenols
in environmental samples: An overview of the last two decades”, discuss all recent advances in the development of
microextraction techniques, such as solid-phase extraction (SPE), solid-phase microextraction (SPME), magnetic solid-phase
microextraction (MSPE), liquid-phase microextraction (LPME), dispersive liquid-liquid microextraction (DLLME), stir bar
sorptive extraction (SBSE), matrix solid-phase dispersion (MSPD), that have been successfully applied in the extraction of bisphenols
from environmental matrices.
The analytical performance of the proposed techniques is critically discussed in this review, highlighting the potential and
limitations of each method.
The Guest Editor wishes to thank all the authors for their fine contribution.
This special issue of Current Analytical Chemistry titled “Imaging for analysis of materials and biological tissues” is dedicated
to the recent developments of advanced imaging methods in three different fields: Materials science, biomedicine, and
plant science. Traditional analytical techniques based on a single-point measurement provide satisfactory results when applied
to homogenous systems. However, most of the natural materials and biological tissues are inherently heterogeneous. Comprehensive
analysis of such materials requires imaging, where an additional spatial coordinate is added to a common analytical
tool to visualize variance within the subject. Given that biological tissue is inherently of low contrast, the addition of endogenous
probes or applying advanced techniques to improve the contrast is necessary. The objective of this special issue is to provide
a forum to present and collate significant and exciting studies involving contrast enhancement aspects of imaging to visualize
and understand critical biological phenomena. Thus this issue presents new exciting directions in the areas of contrast
probe development, instrumentation techniques, and image analysis toward applications in medicine and life science.
In their comprehensive review, a team of scientists led by Yongjian Liu  describes an emerging class of imaging agents
based on ultrasmall nanoclusters (USNCs). These promising imaging probes, typically with a core size less than 2 nm, have
drawn a great deal of attention due to the fact that they exhibit size-dependent physicochemical characteristics. Composed from
just a few hundreds of atoms, the majority of which are located on the surface of the nanocluster, USNCs emonstrate unusual
properties. Strong fluorescence emission and the ability to tune the emission to the near-infrared spectral range makes USNCs
attractive for optical imaging in live animals. Ultrasmall iron oxide NCs (IONCs), with a high ratio of surface magnetic Fe atoms,
are well suited for MRI imaging. Labeling the USNCs with radionuclides made these constructs excellent contrast agents
in positron emission tomography. Moreover, the ultra-small size of USNCs facilitates renal clearance, which is critical for the
development of non-toxic platforms for diagnostic and therapeutic applications.
In another review paper, Gabr and Pigge  describe an interesting class of luminogens that feature aggregation induced
emission (AIE). This class of molecules is typically non-emissive in solution but becomes highly luminescent upon aggregation.
Unlike conventional fluorophores that exhibit aggregation-caused quenching, AIE fluorophores exhibit strong turn-on
emission with low background signal. In addition, AIE fluorophores feature large Stokes’ shifts and excellent photostability –
highly essential and desired properties for efficient imaging. The flexible design of AIE emitters makes them an attractive fit
for a number of applications. The review describes the principles behind the design of the AIE bioprobes, from the detection of
amino acids and metals to imaging of mitochondria and other organelles. The review also discusses the use of AIE probes as a
new generation of diagnostics and therapeutics molecules.
Imaging that enables the assessment of the effect of stress on plants’ health and to predict and improve the crop yield is a
rapidly growing field in plant science. In order to address the need to remotely visualize freeze injury of plants in its earliest
onset, Peng and colleagues have developed a new method based on fluorescence lifetime imaging (FLIM) of leaves. In this
paper , the team explored the changes in the fluorescence lifetime of chlorophyll molecules in leaves. The authors have
demonstrated that the fluorescence lifetime of chlorophyll’s autofluorescence in intact leaves from a model plant periwinkle is
correlated with the degree of injury. The method shows a high sensitivity for detecting injury mere minutes after plant exposure
to -20oc, while no gross visual differences could be distinguished. Conventional color imaging, reflection, or and steady-state
fluorescence intensity showed lower sensitivity in detecting cold stress. The authors suggest that the proposed rapid, remote
method for quantitatively measuring cold stress in situ will aid in selecting cold-tolerant plants.
The papers presented in this focus thematic issue discuss novel challenges in imaging and present new directions. We believe
that the readers of Current Analytical Chemistry will find new stimulating ideas from this thematic issue, and we hope that this
issue will encourage researchers to develop novel imaging tools for biomedical and life science applications and beyond.
We would like to thank all the authors for their excellent contributions, the Editors of “Current Analytical Chemistry” for
this kind invitation to act as a guest editor for this thematic issue, and the valuable assistance by Editorial Manager Syed Faizan
Akhtar in the processing and finalization of this special theme issue.
The special issue entitled "Environmental Contamination, Toxicology, and Safety by Nanocatalysts", published in the
journal of "Current Analytical Chemistry" reports recent studies and applications of nanostructure and nanocomposite materials
for the environment. It is focused on recent research as well as reviews related to the preparation, characterization, and potential
applications of various doped and un-doped or intercalated nano-catalyst materials.
This topic is covering the promising research focusing on the detoxification of wastewater contaminants. It also covers the
advanced topics related to analytical and electrochemical methods covering the scope of various photo-catalysts as well as electro-
catalysts. It attracts the huge attention of scientists towards the development of the non-toxic, easy, ecofriendly way of
preparation-to-potential applications efficient catalyst on a broad scale. Nowadays, potentially unique research work on environmental
pollutants remediation offers various approaches for the development of semiconductor photo-catalyst nanomaterials
Recently, nanotechnology has developed semiconductor nanostructure materials at the nanoscale as well as nanodimensions
which facilitates the application of novel photo-catalytic or electro-catalytic materials in wastewater treatment. The
most dynamic area of photo-catalytic research is introduced with potential applications in areas such as sustainable detoxification
of toxic chemicals, healthcare safety, total mineralization of colored toxicants, and removal of heavy metal cations or anions.
In this issue [1-11], authors have contributed and discussed their findings in the areas such as the role of nano-photocatalysts
for detoxification of various heavy metals, the role of nano-catalyst for wastewater treatment, carbon-nitride based
noble advanced material for photocatalytic applications, nanotechnology-based solutions for wastewater treatment, TiO2 and
their modified forms for air pollution remediation, current development in nanostructure materials and composites for environmental
remediation, significance and antagonistic effect of nano-dimensional materials in sensing, nanostructure materials for
the detection of metallic ions from various effluents, the study on nanotechnology: food and environmental paradigm, and simple
and easy preparation of doped nanostructured materials with improved UV-photo-catalytic performances, etc.
We tried to discuss different kinds of analytical methods for detoxifying the organic and inorganic pollutants with various
hybrids, composites, and nanocomposites, and nanostructured materials. So, here we sincerely believe that this compiled thematic
issue would be very beneficial for the researchers who desire to gain comprehensive knowledge about environmental
remediation. It is also anticipated that this issue would be a useful collection for valuable readers from different parts of the
world. Hopefully, people will find scientific knowledge of photocatalysis from this complied thematic issue. We also hope that
this collection would encourage scientists as well as researchers to attain knowledge in environmental remediation of hazardous
and unsafe chemicals and ions by using different kinds of electro- and phot-chemical techniques.
Finally, we sincerely thank all authors for their excellent contributions as well as the Editors of “Current Analytical
Chemistry” for the kind invitation to act as guest editors for this special thematic issue.
This special issue of “Current Analytical Chemistry” journal, entitled “Photocatalyst for wastewater treatment” is
about the in-depth understanding of the relationship between the structure, the properties or the functions of different kinds of
photocatalytic material. This special issue combines different articles to explain the current work on wastewater treatment, synthesis,
characterization, and applications of the photocatalyst in wastewater treatment. To highlight the importance of photocatalyst,
this special issue reports on the current development in the photocatalyst approach to treat wastewater. Several influential
scientists contributed to share their ideas in this thematic issue. We would like to thank all of them for their valuable contributions
[1-9]. In this thematic issue, there exist seven review papers and two research papers. We tried to combine different
kinds of photocatalytic studies, discussed by various authors, to maintenance the riches of the water. Therefore, we believe that
this thematic issue will be beneficial for the readers who want to seek broad knowledge on this topic.
In this special issue of “Current Analytical Chemistry” journal, named “Current Analytical Techniques and Applications in
Pharmaceutical Analysis”, recent developments on drug analysis, some analytical techniques for pharmaceutical analyses such
as Ultra Performance Liquid Chromatographic Techniques, Box-Behnken Optimized Methodology, electrochemical techniques
etc., are discussed. This special issue includes two volumes, will combine not only different analyzing methods, to support the
prosperity of analytical chemistry, but also development of new researches on pharmaceutical analyses to support the importance
of pharmaceutical studies. Several important scientists contributed to share their ideas in this thematic issue. We
would like to thank them one by one for their valuable contributions.
In this thematic issue Volume I, there exist 7 review papers and 3 research papers. Nowadays, nanostructured materials have
a great variety of applications. Some of them are used in electrochemistry to modify electrodes. Subsequently, in this issue, the
first review, by P. Krzyczmonik and S. Skrzypek, addresses the “Composites of poly (3,4-ethylenedioxythiophene) with
nanostructures as electrochemical sensors for application in bioelectroanalysis” . “Recent progress in the analysis of captopril
using electrochemical Methods” are discussed by Mahesar et al. . In their review, some important applications of electrochemical
modes used for the analysis of captopril, the active pharmaceutical ingredient in antihypertensive drug has been
discussed. This review highlights the role of the analytical instrumentation, particularly electrochemical methods in assessing
captopril using various working electrodes. In another review paper, Fatma Ağın shared researches about “Electroanalytical
methods for determination of calcium channel blockers” . This review mainly includes recent determination studies of calcium
channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples, as calcium channel
blockers are widely used in treatment of cardiovascular heart diseases in recent years.
Furthermore, “Electrochemical sensors based on molecularly imprinted polymers for pharmaceuticals analysis” topic is well
discussed by the authors Radi et al. . This review discussed the development of chemical sensing of drugs in pharmaceutical
formulations and biological matrices using Molecular-Imprinting Polymer (MIP) as a recognition element combined with different
electrochemical signal transduction. The MIP electrochemical sensors based on nanomaterials such as graphene, carbon
nanotubes, nanoparticles, as well as other electrode modifiers incorporated into the MIPs to enhance the sensors performance,
have been reviewed.
In another review contribution, entitled as “Voltammetric analysis of atypical antipsychotic drugs with solid electrodes” has
found place by Dilek Kul . This review presents voltammetric methods used for the determination of some electrochemically
active atypical antipsychotic drugs, which are amisulpride, aripiprazole, clozapine, olanzapine, quetiapine fumarate, risperidone,
sertindole, and ziprasidone, in pure solutions, pharmaceutical dosage forms and biological samples using various unmodified
and modified solid electrodes. Another interesting review paper suggested by Srivastava et al., entitled as “Voltammetric
techniques for the analysis of drugs using nanomaterials based chemically modified electrodes” . Their paper focuses solely
on application of electroanalytical techniques for individual and simultaneous analysis of drugs as well as in pharmaceutical
formulations of dosage forms and biological media such as blood serum, urine, etc. for various classes of drugs such as analgesics,
anti-helmentics, anti-tuberculosis, cardiovascular, antipsychotics, anti-allergic, antibiotics and gastro-intestinal.
Besides, Kurbanoglu et al., contributed to this thematic issue with a motivating review paper entitled as “Recent advances on
drug analyses using Ultra Performance Liquid Chromatographic (UPLC) techniques and their application to the biological
samples” . The recent selected studies related to the UPLC method and its method validation were summarized, and the results
of these studies with certain parameters obtained from literature were presented. Guzmán et al., contributed to our thematic
issue with a research paper entitled as “A Box-Behnken Optimized Methodology for the Quantification of Diclofenac using a Carbon
Paste-Multiwalled Carbon Nanotubes Electrode” . This paper presents the development of an optimized voltammetric
methodology for the quantification of diclofenac, which offers some advantages over other electrochemical and accepted methods.
In another contribution, “Electrochemical detection of ct-dsDNA on nanomaterial-modified carbon based electrodes” is reported
by Bozal-Palabiyik et al. . This paper reports preparation, characterization of two different nanomaterials and their electrochemical
application on double stranded calf-thymus DNA signals. Here, the multi-walled carbon nanotubes were functionalized with
amine groups (MWCNTs-NH2) by employing the dielectric barrier discharge plasma treatment. Both dsDNA modified electrodes
were employed to explore the interaction between the dsDNA and the anticancer drug etoposide in aqueous solution through
In the last contribution, again a research paper was appeared by Secci et al., entitled as “Investigation on the stability of new
biologically active thiosemicarbazone-derived compounds by a validated HPLC-PDA method” . This paper reports the development and validation of an HPLC-PDA method for the simultaneous determination and chemical-physical stability evaluation
after forced decomposition studies of thiosemicarbazone-derived compounds endowed with interesting pharmacological
We tried to combine different kinds of analyzing methods, discussed by different authors, to maintenance the riches of analytical
chemistry. Therefore, we believe that this thematic issue will be very useful for the readers that wanted to have broad
knowledge. We believe that you, as the valuable readers of Current Analytical Chemistry journal, will find out new information,
topic of interest, new ideas from this thematic issue and we hope that this thematic issue will encourage researches to
achieve analysis of pharmaceutical active compounds using different kinds of methods.
We would like to thank all of the authors one more time for their excellent contributions, the Editors of “CURRENT
ANALYTICAL CHEMISTRY” for this kind invitation to act as guest editors for this thematic issue and the valuable assistance
by Editorial Manager, Syed Faizan Akhtar in the processing and finalization of this special theme issue.
Analytical scientists due to unique properties of nanomaterials increased fabrications of nanostructure analytical sensors in
the recent years. Nano-materials with high surface area and good stability are good choice for improving sensitivity analytical
sensor for food, biological and pharmaceutical compounds analyses. Nano-material such as carbon nanotubes, metal oxide nanoparticles,
graphene, polymer nanostructures and etc. suggested for application in analytical techniques such as voltammetry,
spectroscopy, and chromatography. The published papers confirmed high quality of nanomaterials for improving trace level
analysis of important food, pharmaceutical and environmental analysis. Therefore, recent modified methods were used nanomaterials
as important part in fabrication of novel analytical sensors.
The scope of this issue focuses on the strategies for determination of food, biological, pharmaceutical and environmental
compounds using modified nanostructure sensors. This special issue included 7 reviews and 3 research article about application
of nanomaterials in fabrication of analytical sensors.
In paper 1, Faridbod et al., described a review paper about the graphene quantum dots in fabrication of electrochemical sensors/
biosensors. They discuss about the ways synthesis of graphene quantum dots and fabricated sensors or biosensors modified
with graphene quantum dots.
In paper 2, the electrochemical sensors modified with various nanomaterials discussed for determination of sulfonamides. In
this paper, history of developing voltammetric sensors based on nanomaterials for the detection of sulfonamides including sulfadiazine,
sulfamethoxazole, sulfacetamide, sulfadimethoxine, sulfathiazole, sulfamethiazole and sulfamerazine is reviewed.
In paper 3, new emerging one-dimensional nanostructure materials for gas sensing application described by Bharti et al.
This review focused for application of nanomaterials in fabrication of gas sensors.
In paper 4, the ability of metal-based nanoparticles as conductive mediators in electrochemical sensors was investigated.
The metal-based nanoparticles such as Au nanoparticle, Pt nanoparticle, Fe3O4 nanoparticle and etc. is reviewed by Karimi-
Maleh et al.
In paper 5, application of advanced electrochemical methods with nanomaterial-based electrodes as powerful tools for trace
analysis of drugs and toxic compounds is reviewed.
In paper 6, Pourbasheer et al discussed recent advanced in biosensors based nanostructure for pharmaceutical analysis (~ 73
In paper 7, development of novel nanocomposites based on graphene/graphene oxide and electrochemical sensor applications.
In the paper 8, simultaneous determination of epinephrine and tyrosine using a glassy carbon electrode amplified with ZnOPt/
CNTs nanocomposite described by Samadzadeh et al.
In paper 9, we describe application of CdO decorated single wall carbon nanotubes as a conductive nanomaterial for modification
of carbon paste electrode. The nanostructure sensor showed high sensitivity for determination of tertbutylhydroxyanisole
as a food antioxidant.
In paper 10, the role of NiO nanoparticle decorated single wall carbon nanotubes discussed for fabrication of new electrochemical
sensor for determination of mycophenolate mofetil by Hosseini et al.
I hope that in the special issue of Current Analytical Chemistry that collected in different fields relative to the application of
nanomaterial for fabrication of analytical sensors useful for readers.
Plasticizers are organic compounds added to polymers to facilitate processing and increase flexibility and toughness of the
final product by internal modification of the polymer molecule. Many plasticizers are considered as endocrine disruptors and
show activity on the reproductive system or act as carcinogens. They can be released into the environment through leaching
from final products and during manufacturing processes. The most commonly used plasticizers are phthalates, which comprise
approximately 90% of plasticizer production in the world. Since phthalates are not chemically bound to the materials they are
used in, they can be released from the products that contain them, for instance into water and air. There is public concern about
phthalates because of their widespread use and occurrence in the environment as well as their potential effects on human health.
Other organic contaminants highly used as plasticizers are alkylphenols, namely octylphenol and nonylphenol, bisphenol A or
benzophenone. The analysis of all these compounds relies on the use of methods allowing their unequivocal identification in
complex environmental matrices. Gas chromatography coupled to mass spectrometry or high-performance liquid chromatography
coupled with tandem mass spectrometry are the most commonly used techniques for the analysis of these compounds. Furthermore,
metabolomics, the comprehensive analysis of metabolites in a biological system, which provides detailed information
about the biochemical /physiological status of a biological system and the changes caused by chemicals, can be used to assess
the toxicity of food plasticizers.
Aim of this thematic issue on Biopolymers and Biocomposites: Chemistry and Technology in journal Current Analytical
Chemistry to disseminate critical review and research findings in the area of biopolymers and biocomposites focusing on the
chemistry and technology aspects of the materials. This special issue consists of research and review articles in the areas of
chemistry and technology of biopolymers and biocomposites contributed by experts from worldwide. In this special issue we
covered vast topics such as A review on phenolic resin, Thermo-mechanical properties of flax fibre reinforced composites,
Next generation biomimetic bone tissue engineering from PLA/CaCO3 composites, Nanocrystalline cellulose as reinforcement
for polymeric matrix nanocomposites and its potential applications: A Review, Seaweeds as renewable sources for biopolymers
and its composites: A review, Recent Advances in Silver Nanoparticle Containing Biopolymer Nanocomposites for Infectious
Disease Control – A Mini Review, On the Effects of Geometrical Shapes in Failure Modes in Natural – Conventional Fiber
Reinforced Composite Tube (A review), New Generation Antibacterial Nanofibrous Membrane for Potential Water Filtration,
Review of kenaf reinforced hybrid biocomposites: Potential in defence applications, and Starch Cellulosic Bio-composites: A
Sustainable and Multifunctional Material for Green Technology from leading experts from Malaysia, Canada, Saudi Arabia,
UK, UAE, Denmark, Australia, Libya, and Qatar.
We are highly thankful to all authors who contributed in to this special issue and make made our thoughtful idea possible in
to bring in reality. Besides, that we are also thankful to Bentham Science Publishers and their supporting team, especially Mr.
Syed Faizan Akhtar, for helping assisting us during preparation till finalization of our this thematic special issue.