Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Editor-in-Chief

Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)

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Volume: 13 Issue: 4, May 2013

Editorial (Hot Topic: Survival Signaling Through Focal Adhesion Kinase in Tumors)

Volume:13   Issue: 4
Pp: 531-531
Vita M. Golubovskaya
DOI: 10.2174/1871520611313040001
Published on: 08 March, 2013

A Small-molecule Inhibitor, 5'-O-Tritylthymidine, Targets FAK and Mdm-2 Interaction, and Blocks Breast and Colon Tumorigenesis in vivo

Volume:13   Issue: 4
Pp: 532-545
Vita M. Golubovskaya, Nadia L. Palma, Min Zheng, Baotran Ho, Andrew Magis, David Ostrov and William G. Cance
DOI: 10.2174/1871520611313040002
Published on: 08 March, 2013

Mitoxantrone Targets the ATP-binding Site of FAK, Binds the FAK Kinase Domain and Decreases FAK, Pyk-2, c-Src, and IGF-1R In Vitro Kinase Activities

Volume:13   Issue: 4
Pp: 546-554
Vita M. Golubovskaya, Baotran Ho, Min Zheng, Andrew Magis, David Ostrov and William G. Cance
DOI: 10.2174/1871520611313040003
Published on: 08 March, 2013

Upregulation of Focal Adhesion Kinase by 14-3-3ε via NFκB Activation in Hepatocellular Carcinoma

Volume:13   Issue: 4
Pp: 555-562
Bor-Sheng Ko, Yee-Jee Jan, Tzu-Ching Chang, Shu-Man Liang, Shyh-Chang Chen, Tzu-An Liu, Yao-Ming Wu, John Wang and Jun-Yang Liou
DOI: 10.2174/1871520611313040004
Published on: 08 March, 2013

Cell Survival Signaling in Neuroblastoma

Volume:13   Issue: 4
Pp: 563-575
Michael L. Megison, Lauren A. Gillory and Elizabeth A. Beierle
DOI: 10.2174/1871520611313040005
Published on: 08 March, 2013

FAK and Nanog Cross Talk with p53 in Cancer Stem Cells

Volume:13   Issue: 4
Pp: 576-580
Vita M. Golubovskaya
DOI: 10.2174/1871520611313040006
Published on: 08 March, 2013

The Role of Focal Adhesion Kinase in Lung Cancer

Volume:13   Issue: 4
Pp: 581-583
Grace K. Dy
DOI: 10.2174/1871520611313040007
Published on: 08 March, 2013

FAK and HAS Inhibition Synergistically Decrease Colon Cancer Cell Viability and Affect Expression of Critical Genes

Volume:13   Issue: 4
Pp: 584-594
Melissa Heffler, Vita M. Golubovskaya, Jeffrey Conroy, Song Liu, Dan Wang, William G. Cance and Kelli B. Dunn
DOI: 10.2174/1871520611313040008
Published on: 08 March, 2013

Inhibiting the Interaction of cMET and IGF-1R with FAK Effectively Reduces Growth of Pancreatic Cancer Cells in vitro and in vivo

Volume:13   Issue: 4
Pp: 595-602
Deniz A. Ucar, Andrew T. Magis, Di-Hua He, Nicholas J. Lawrence, Said M. Sebti, Elena Kurenova, Maria Zajac-Kaye, Jianliang Zhang and Steven N. Hochwald
DOI: 10.2174/1871520611313040009
Published on: 08 March, 2013

Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status

Volume:13   Issue: 4
Pp: 603-631
Karina Petit and Jean-Francois Biard
DOI: 10.2174/1871520611313040010
Published on: 08 March, 2013

Synthesis and Anticancer Properties of a Novel Bis-intercalator

Volume:13   Issue: 4
Pp: 632-638
Wei Shen, Huimin Deng and Zhiqiang Gao
DOI: 10.2174/1871520611313040011
Published on: 08 March, 2013

Differential Binding Preference of Methylpheophorbide a and Its Diboronated Derivatives to Albumin and Low Density Lipoproteins

Volume:13   Issue: 4
Pp: 639-646
Galina V. Golovina, Georgy N. Rychkov, Valentina A. Ol’shevskaya, Andrei V. Zaitsev, Valery N. Kalinin, Vladimir A. Kuzmin and Alexander A. Shtil
DOI: 10.2174/1871520611313040012
Published on: 08 March, 2013

Antitumoral Activity of Indole-3-carbinol Cyclic tri- and Tetrameric Derivatives Mixture in Human Breast Cancer Cells: In Vitro and In Vivo Studies

Volume:13   Issue: 4
Pp: 654-662
Giorgio Brandi, Alessandra Fraternale, Simone Lucarini, Mirko Paiardini, Mauro De Santi, Barbara Cervasi, Maria F. Paoletti, Luca Galluzzi, Andrea Duranti and Mauro Magnani
DOI: 10.2174/1871520611313040014
Published on: 08 March, 2013

Recombinant Snake Venom Cystatin Inhibits Tumor Angiogenesis in vitro and in vivo Associated with Downregulation of VEGF-A165, Flt-1 and bFGF

Volume:13   Issue: 4
Pp: 663-671
Qun Xie, Nanhong Tang, Rong Wan, Yuanlin Qi, Xu Lin and Jianyin Lin
DOI: 10.2174/1871520611313040015
Published on: 08 March, 2013

N6-Isopentenyladenosine and its Analogue N6-Benzyladenosine Induce Cell Cycle Arrest and Apoptosis in Bladder Carcinoma T24 Cells

Volume:13   Issue: 4
Pp: 672-678
Sara Castiglioni, Silvana Casati, Roberta Ottria, Pierangela Ciuffreda and Jeanette A.M. Maier
DOI: 10.2174/1871520611313040016
Published on: 08 March, 2013