Abstract
Neutropenia and/or agranulocytosis are among the medicinal side-effects induced by many psychotropic drugs. Clozapine and carbamazepine cause the highest incidence of this side-effect and require long-term blood cell monitoring. Bone marrow suppression can have an allergic, hypersensitivity etiology (e.g., clozapine), which mandates the causative drug discontinuation. It can also be a direct, toxic effect (e.g., carbamazepine), which calls for dosage reduction or a medication change. Other treatment options may include filgrastim, sargramostim, or lithium. Blood cell count monitoring is encouraged on patients receiving clozapine as long as the drug is continued. Such evaluation is also advised on those medicated with other psychotropics, especially carbamazepine.
Keywords: Agranulocytosis, granulocytopenia, leukopenia, psychotropic medication-induced blood dyscrasia, bone marrow suppression with psychopharmaceuticals
Current Drug Targets
Title: Psychotropic Medications and Leukopenia
Volume: 7 Issue: 9
Author(s): Karim Sedky and Steven Lippmann
Affiliation:
Keywords: Agranulocytosis, granulocytopenia, leukopenia, psychotropic medication-induced blood dyscrasia, bone marrow suppression with psychopharmaceuticals
Abstract: Neutropenia and/or agranulocytosis are among the medicinal side-effects induced by many psychotropic drugs. Clozapine and carbamazepine cause the highest incidence of this side-effect and require long-term blood cell monitoring. Bone marrow suppression can have an allergic, hypersensitivity etiology (e.g., clozapine), which mandates the causative drug discontinuation. It can also be a direct, toxic effect (e.g., carbamazepine), which calls for dosage reduction or a medication change. Other treatment options may include filgrastim, sargramostim, or lithium. Blood cell count monitoring is encouraged on patients receiving clozapine as long as the drug is continued. Such evaluation is also advised on those medicated with other psychotropics, especially carbamazepine.
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Cite this article as:
Sedky Karim and Lippmann Steven, Psychotropic Medications and Leukopenia, Current Drug Targets 2006; 7 (9) . https://dx.doi.org/10.2174/138945006778226642
DOI https://dx.doi.org/10.2174/138945006778226642 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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