Abstract
We present a comprehensive but not exhaustive review of new trends in drug discovery and targets for cancer and AIDS which begins by highlighting the different historical stages of drug discovery from clinical diagnosis, natural compounds, serendipity and chemotherapy to the present age of modern experimental and computational techniques. The current state of the art of computer-aided drug design and selected recent applications to Cancer and AIDS are discussed. Novel targets and drugs in Cancer and AIDS are analyzed. In conclusion, future perspectives for drug discovery, design and therapeutics in cancer and AIDS are presented.
Keywords: HIV-1, non-nucleoside reverse transcriptase inhibitors (NNRTIs), chemokine co-receptors, anti-VEGF antibody, molecular modeling (MM)
Current Computer-Aided Drug Design
Title: Cancer and Aids: New Trends in Drug Design and Chemotherapy
Volume: 2 Issue: 3
Author(s): Carlton Anthony Taft and Carlos Henrique Tomich de Paula da Silva
Affiliation:
Keywords: HIV-1, non-nucleoside reverse transcriptase inhibitors (NNRTIs), chemokine co-receptors, anti-VEGF antibody, molecular modeling (MM)
Abstract: We present a comprehensive but not exhaustive review of new trends in drug discovery and targets for cancer and AIDS which begins by highlighting the different historical stages of drug discovery from clinical diagnosis, natural compounds, serendipity and chemotherapy to the present age of modern experimental and computational techniques. The current state of the art of computer-aided drug design and selected recent applications to Cancer and AIDS are discussed. Novel targets and drugs in Cancer and AIDS are analyzed. In conclusion, future perspectives for drug discovery, design and therapeutics in cancer and AIDS are presented.
Export Options
About this article
Cite this article as:
Anthony Taft Carlton and Henrique Tomich de Paula da Silva Carlos, Cancer and Aids: New Trends in Drug Design and Chemotherapy, Current Computer-Aided Drug Design 2006; 2 (3) . https://dx.doi.org/10.2174/157340906778226382
DOI https://dx.doi.org/10.2174/157340906778226382 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Pivotal Role of Multimodality Reporter Sensors in Drug Discovery: From Cell based Assays to Real Time Molecular Imaging
Current Pharmaceutical Biotechnology Physiological and Pathological Functions of Acid-Sensing Ion Channels in the Central Nervous System
Current Drug Targets Anticancer Advances of Matrine and Its Derivatives
Current Pharmaceutical Design Targeting the Tumor Proteasome as a Mechanism to Control the Synthesis and Bioactivity of Matrix Macromolecules
Current Molecular Medicine Modular Protein Engineering in Emerging Cancer Therapies
Current Pharmaceutical Design Astrocytic Target Mechanisms in Epilepsy
Current Medicinal Chemistry Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Current Drug Metabolism Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment
Current Neuropharmacology Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Current Pharmaceutical Design Neurokinin-1 Receptor Antagonists in Lung Cancer Therapy
Letters in Drug Design & Discovery The Plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-regulating NFIX.
Current Molecular Medicine Gender Hormones: Role in the Pathogenesis of Central Nervous System Disease and Demyelination
Current Neurovascular Research Antibody-Targeted Immunoliposomes for Cancer Treatment
Mini-Reviews in Medicinal Chemistry 3-Carboranyl Thymidine Analogues (3CTAs) and Other Boronated Nucleosides for Boron Neutron Capture Therapy
Anti-Cancer Agents in Medicinal Chemistry The Potential Targets and Mechanisms of a Carbazole and Pyrazole Containing Anticancer Compound
Current Cancer Drug Targets Development of Novel, Highly Cytotoxic Fusion Constructs Containing Granzyme B: Unique Mechanisms and Functions
Current Pharmaceutical Design Curcumin in Combined Cancer Therapy
Current Pharmaceutical Design Autologous Formalin-Fixed Tumor Vaccine
Current Pharmaceutical Design Resistance to Anti-VEGF Agents
Current Pharmaceutical Design Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy
Current Cancer Drug Targets